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Anti-inflammatory and Antiapoptotic Effects of Mesenchymal Stem Cells Transplantation in Rat Brain with Cerebral Ischemia
Excessive inflammation and apoptosis contribute to the pathogenesis of ischemic brain damage. Nuclear factor-kappa B (NF-κB) is considered to be a key protein complex involved in this cascade of events. The aim of the present study was to clarify the protection mechanism of the mesenchymal stem cells (MSCs).
Source: Journal of Stroke and Cerebrovascular Diseases - September 30, 2014 Category: Neurology Authors: Naibing Gu, Chunguang Rao, Ye Tian, Zhengli Di, Zhiqin Liu, Mingze Chang, Hui Lei Source Type: research

Effects of Noggin-Transfected Neural Stem Cells on Neural Functional Recovery and Underlying Mechanism in Rats with Cerebral Ischemia Reperfusion Injury
To investigate neuroprotection of noggin-transfected neural stem cells (NSCs) against focal cerebral ischemia reperfusion injury (IRI) in rats.
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2017 Category: Neurology Authors: Jun-de Zhu, Jun-jie Wang, Guo Ge, Chao-sheng Kang Source Type: research

Multiple Lacunar Infarcts in Paroxysmal Nocturnal Hemoglobinuria
We report a case of a 49-year-old woman who has a medical history of diabetes mellitus, hypertension, and PNH and presented multiple lacunar strokes in a routine consultation with a hematologist.
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2017 Category: Neurology Authors: Alex Tiburtino Meira, Gabriel Sampaio Froehner, Andr é Petean Trindade, Silméia Garcia Zanati Bazan, Gabriel Pereira Braga, Rodrigo Bazan Tags: Case Studies Source Type: research

Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Rat Brain From Ischemia-Induced Damage
Background: Survival following cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR), to a great extent, depends on brain damage. Adipose-derived stem cells (ADSCs), as a source of paracrine growth factors and the capacity of neural differentiation may reduce this brain damage. Objective: The purpose of this study is to evaluate the protection of ADSCs to brain damage following CPR. Methods: Rats were divided into 3 groups, sham, CA, and ADSCs group. Rats in sham group went through sham surgery.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2018 Category: Neurology Authors: Bo Gong, Yongpin Dong, Chao He, Weiwei Jiang, Yi Shan, Betty Y. Zhou, Wenfang Li Source Type: research

Rapidly Progressive Intracranial Vasculopathy in Graft Versus Host Disease
We report a previously undescribed noninflammatory vasculopathy causing multifocal intracranial arterial occlusions and cerebral infarctions in a man following allogenic hematopoietic stem cell transplantation for chronic lymphocytic leukemia, which we propose to be a central nervous system manifestation of graft versus host disease.
Source: Journal of Stroke and Cerebrovascular Diseases - March 12, 2019 Category: Neurology Authors: Theodore Bowen, Shawn A. Silver, Cathy Sila Tags: Case Report Source Type: research

Effects of GDNF-Transfected Marrow Stromal Cells on Rats with Intracerebral Hemorrhage
Objective: The present study aimed to investigate the effects of Mesenchymal stem cells/glial cell line derived neurotrophic factor (MSCs/GDNF) transplantation on nerve reconstruction in rats with intracerebral hemorrhage. Methods: GDNF transduction to MSCs was using adenovirus vector pAdEasy-1-pAdTrack-CMV prepared. Intracerebral hemorrhage (ICH) was induced by injection of collagenase and heparin into the caudate putamen. At the third day after a collagenase-induced ICH, adult male SD rats were randomly divided into saline group, MSCs group and MSCs/GDNF group.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2019 Category: Neurology Authors: Li Deng, Xiaoqing Gao, Guangbi Fan, Chaoxian Yang Source Type: research

Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage
In this study, we isolated, cultured and identified bone marrow mesenchymal stem cells (MSCs) in vitro. Further, the MSCs (transfected with lentivirus expressing microRNA-126a-3p (miR-126)) were injected into the type Ⅶ collagenase-induced ICH rats to investigate the recovery effects of blood-brain barrier (BBB) and nerve damage in vivo.
Source: Journal of Stroke and Cerebrovascular Diseases - March 8, 2020 Category: Neurology Authors: Chunyan Wang, Jingwei Cao, Shurong Duan, Ran Xu, Hongli Yu, Xin Huo, Yuanyuan Qian Source Type: research

Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha
To assess the potential effect of dl-3-N-butylphthalide (dl-NBP) for the proliferation and differentiation of neural stem cells (NSCs) against hypoxia and the underlying mechanism.
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2021 Category: Neurology Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen Source Type: research

Exosomes Released from Bone-Marrow Stem Cells Ameliorate Hippocampal Neuronal Injury Through transferring miR-455-3p
Ischemia/reperfusion (I/R) injury represents a leading cause of graft loss and dysfunction during clinical transplantation and organ resection.1 I/R injury damages neuronal function and contributes to cell death and the following neurological impairment.2 Despite the prevalence and devastating costs of brain ischemia, managing I/R injury depends primarily on supportive measures, as specific treatment strategies are still out of reach.3 The intracellular mechanisms of acute brain injury in I/R remains poorly understood, and developing therapeutic interventions alleviating the tissue damage has been the focus of recent studies.
Source: Journal of Stroke and Cerebrovascular Diseases - May 19, 2022 Category: Neurology Authors: Chao Gan, Feng Ouyang Source Type: research

Bone marrow-derived mesenchymal stem cells overexpressed with miR-182-5p protects against brain injury in a mouse model of cerebral ischemia
This study investigates whether overexpressing miR-182-5p in bone marrow-derived mesenchymal stem cells (BM-MSCs) could potentiate the neuroprotective effects of BM-MSCs in a mouse model of ischemic brain injury.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2022 Category: Neurology Authors: Mingyang Deng, Jianyang Liu, Jialin He, Ziwei Lan, Shuangxi Cheng, Zhiping Hu, Han Xiao Source Type: research

Temporal patterns and distribution of pyroptosis-related molecules and effects of human mesenchymal stem cells on pyroptosis following cerebral ischemia/reperfusion in rats
Pyroptosis is a new type of programmed cell death that has a strong proinflammatory effect. The present study investigated the dynamic changes of pyroptosis-related molecules and the effect of mesenchymal stem cells (MSCs) on pyroptosis following cerebral ischemia/reperfusion (I/R).
Source: Journal of Stroke and Cerebrovascular Diseases - May 31, 2023 Category: Neurology Authors: Kuang Pan, Qingxia Peng, Zejia Huang, Zhaofei Dong, Weijye Lin, Yidong Wang Source Type: research

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