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Source: Journal of Stroke and Cerebrovascular Diseases
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Total 349 results found since Jan 2013.
Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research
High Detection Rate of Atrial Fibrillation With Insertable Cardiac Monitor Implantation in Patients With Cryptogenic Stroke Diagnosed by Magnetic Resonance Imaging
Background: Detection and treatment of atrial fibrillation (AF) is a major goal in preventing secondary stroke. Insertable cardiac monitors (ICMs) are available for diagnosis of arrhythmia monitoring in patients with cryptogenic stroke. Magnetic resonance imaging (MRI)-based diagnostic evaluation for acute ischemic stroke subtype classification is common in Japan and can be useful for specific diagnosis of cryptogenic stroke. Purpose: We aimed to investigate the detection rate of AF with an ICM in patients with cryptogenic stroke who were diagnosed by MRI.
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2019 Category: Neurology Authors: Tomonori Iwata, Kenichi Todo, Hiroshi Yamagami, Masafumi Morimoto, Tetsuya Hashimoto, Ryosuke Doijiri, Hiroyuki Furuya Source Type: research
Cerebral Microbleeds on T2*-Weighted Images and Hemorrhagic Transformation after Antithrombotic Therapies for Ischemic Stroke
In conclusion, the severity of neurological deficits and the ASPECTS-DWI are closely correlated to the development of HT related to anticoagulants/antiplatelets but not to CMBs on T2*-weighted images.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Wakoh Takahashi, Yusuke Moriya, Atsushi Mizuma, Tsuyoshi Uesugi, Yoichi Ohnuki, Shunya Takizawa Tags: Original Articles Source Type: research
Determinants of White Matter Hyperintensity Burden Differ at the Extremes of Ages of Ischemic Stroke Onset
Age is a well-known risk factor for both stroke and increased burden of white matter hyperintensity (WMH), as detected on magnetic resonance imaging (MRI) scans. However, in patients diagnosed with ischemic stroke (IS), WMH volume (WMHv) varies significantly across age groups. We sought to examine the determinants of WMH burden across the ages of stroke onset with the goal to uncover potential age-specific stroke prevention targets.
Source: Journal of Stroke and Cerebrovascular Diseases - January 6, 2015 Category: Neurology Authors: Cathy R. Zhang, Lisa Cloonan, Kaitlin M. Fitzpatrick, Allison S. Kanakis, Alison M. Ayres, Karen L. Furie, Jonathan Rosand, Natalia S. Rost Source Type: research
Transient Ischemic Attack Fast-track and Long-Term Stroke Risk: Role of Diffusion-Weighted Magnetic Resonance Imaging
In this study, we evaluated the role of positive DWI lesions and vascular risk factors on stroke, cardiovascular death, and mortality at 90 days (T0), 1 year (T1), and 5 years (T2). Moreover, we also evaluated the association between stroke risk and the presence of DWI lesions.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2015 Category: Neurology Authors: Sabrina Anticoli, Francesca Romana Pezzella, Claudio Pozzessere, Luca Gallelli, Maria Cristina Bravi, Valeria Caso, Antonio Siniscalchi Source Type: research
Does the Primary Imaging Modality —Computed Tomography or Magnetic Resonance Imaging—Influence Stroke Physicians' Certainty on Whether or Not to Give Thrombolysis to Randomized Acute Stroke Patients?
Door-to-needle time of 20 minutes to stroke patients with intravenous tissue plasminogen activator (iv-tPA) is feasible when computed tomography (CT) is used as first-line of brain imaging. Magnetic resonance imaging (MRI)-based assessment is more time-consuming but superior in detecting acute ischemia. The certainty with which stroke physicians prescribe or refrain from giving iv-tPA treatment to CT- versus MRI-examined patients has not previously been studied. The aim of the present study was to determine the effect of a primary imaging strategy of CT or MRI on clinicians' certainty to prescribe or refrain from giving iv...
Source: Journal of Stroke and Cerebrovascular Diseases - November 30, 2017 Category: Neurology Authors: Christine Krarup Hansen, Anders Christensen, Helen Rodgers, Inger Havsteen, Christina Kruuse, Hanne Christensen Source Type: research
Early Magnetic Resonance Imaging Decreases Hospital Length of Stay in Patients with Ischemic Stroke
Imaging modalities are important part of stroke evaluation. Noncontrast head computed tomography (CT) is the initial imaging modality in acute stroke and although important to rule out acute hemorrhage and making a decision on thrombolytic treatment, ischemic changes may not be visible on CT for up to 24 hours. Magnetic resonance imaging (MRI) brain is an invaluable tool to confirm an ischemic stroke and facilitates stroke evaluation. Objective of this study was to investigate the correlation between time to MRI and length of hospital stay.
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Bharti Manwani, Subhendu Rath, Nora S. Lee, Ilene Staff, Christoph Stretz, Janhavi Modak, Pasquale F. Finelli Source Type: research
Criteria for Emergency Brain MRI During Stroke-Alert
Intravenous (IV) tissue plasminogen activator (tPA) should be given to patients with acute ischemic stroke (AIS) and avoided in stroke mimics (SM). Select use of emergency brain magnetic resonance imaging (eMRI-brain) in stroke-alerts aids diagnosis, but accepted utilization criteria for eMRI-brain do not currently exist. We developed criteria for eMRI-brain and report the yield of eMRI-brain in stroke-alert patients.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Evgeny Sidorov, Courtney Iser, Nidhi Kapoor, Bappaditya Ray, Juliane Chainakul, Chao Xu, Andrei V. Alexandrov, David Lee Gordon Source Type: research
Diversity of Stroke Presentation in CADASIL: Study from Patients Harboring the Predominant NOTCH3 Mutation R544C
This study investigated the clinical stroke presentation and cranial magnetic resonance imaging (MRI) findings in a group of patients with CADASIL. We reviewed the clinical stroke presentation and brain MRI findings in 73 consecutive Korean patients aged>18 years diagnosed with CADASIL between May 2004 and April 2009. Brain MRI images were also scored for lacunar infarction and cerebral microbleeds. Intracranial atherosclerosis (ICAS) was assessed by magnetic resonance angiography. Disability was measured with the modified Rankin scale (mRS) and classified as good (mRS score 0-2) or poor (mRS score 3-5). In this study, 65 ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2011 Category: Neurology Authors: Jay Chol Choi, Sook-Keun Song, Jung Seok Lee, Sa-Yoon Kang, Ji-Hoon Kang Tags: Original Articles Source Type: research
Phase I Study of Intravenous Low-dose Granulocyte Colony-stimulating Factor in Acute and Subacute Ischemic Stroke
We examined the safety and tolerability of low-dose G-CSF and investigated the effectiveness of G-CSF given intravenously in the acute phase (at 24 hours) or subacute phase (at 7 days) of ischemic stroke.Methods: Three intravenous dose regimens (150, 300, or 450 μg/body/day, divided into 2 doses for 5 days) of G-CSF were examined in 18 patients with magnetic resonance imaging (MRI)–confirmed infarct in the territory of the middle cerebral artery. Nine patients received the first dose at 24 hours poststroke (acute group) and 9 patients received the first dose on day 7 poststroke (subacute group; n = 3 at each dose in ea...
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2012 Category: Neurology Authors: Yusuke Moriya, Atsushi Mizuma, Tsuyoshi Uesugi, Yoichi Ohnuki, Eiichiro Nagata, Wakoh Takahashi, Hiroyuki Kobayashi, Hiroshi Kawada, Kiyoshi Ando, Shigeharu Takagi, Shunya Takizawa Tags: Original Articles Source Type: research
Impact of Window Setting Optimization on Accuracy of Computed Tomography and Computed Tomography Angiography Source Image-based Alberta Stroke Program Early Computed Tomography Score
This study analyzed the effect of optimization of window settings on the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) performed on noncontrast CT (NCCT) and CT angiography source images (CTA-SI). ASPECTS was calculated on NCCT and CTA-SI with standard and optimized window width/center settings in a consecutive series of patients with acute ishcemic stroke. The difference between CT-based ASPECTS and ASPECTS performed on follow-up magnetic resonance imaging (MRI) were calculated to determine the disparity between initial estimates of the extent of ischemia on CT and follow-up lesion imaging b...
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2012 Category: Neurology Authors: Ethem Murat Arsava, Jukka T. Saarinen, Ali Unal, Erhan Akpinar, Kader K. Oguz, Mehmet Akif Topcuoglu Tags: Original Articles Source Type: research
Ischemic Stroke in Evolution: Predictive Value of Perfusion Computed Tomography
Background: Various perfusion computed tomography (PCT) parameters have been used to identify tissue at risk of infarction in the setting of acute stroke. The purpose of this study was to examine predictive value of the PCT parameters commonly used in clinical practice to define ischemic penumbra. The patient selection criterion aimed to exclude the effect of thrombolysis from the imaging data.Methods: Consecutive acute stroke patients were screened and a total of 18 patients who initially underwent PCT and CT angiogram (CTA) on presentation but did not qualify to receive thrombolytic therapy were selected. The PCT images ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Amir Kheradmand, Marc Fisher, David Paydarfar Tags: Original Articles Source Type: research
Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging
Improving cerebral perfusion remains a good option for ischemic stroke for restoring cerebral blood flow. Human urinary kallidinogenase has been shown promising in treating stroke patients. To investigate whether human urinary kallidinogenase's efficacy in treating stroke patients has relationship with improving cerebral perfusion and possible mechanism.
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2015 Category: Neurology Authors: Jingwei Li, Yan Chen, Xin Zhang, Bing Zhang, Meijuan Zhang, Yun Xu Source Type: research
Brain Magnetic Resonance with Negative Diffusion-Weighted Imaging: Does It Preclude Acute Stroke Diagnosis?
Brain magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) sequences and correlative apparent diffusion coefficient (ADC) maps is a very sensitive way to detect acute ischemic stroke. Cases of negative MRI–DWI on acute phase of ischemic stroke are uncommon, and most of them are reported in single small-sized lesions, which in most cases are below the technical spatial resolution and in patients imaged shortly after the symptoms start. The few published cases of territorial ischemic stroke with negative DWI affect exclusively one vascular territory.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2015 Category: Neurology Authors: Catarina Aragão Homem, Ana Catarina Fonseca, Ruth Geraldes, Teresa Pinho e Melo Tags: Case Report Source Type: research
Magnetic Resonance Imaging White Matter Hyperintensity as a Predictor of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source
This study aimed to investigate factors associated with stroke recurrence and new-onset atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS).
Source: Journal of Stroke and Cerebrovascular Diseases - September 21, 2018 Category: Neurology Authors: Satoru Kashima, Takahiro Shimizu, Hisanao Akiyama, Yasuhiro Hasegawa Source Type: research
