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Source: Cell Transplantation
Therapy: Stem Cell Therapy

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Total 87 results found since Jan 2013.

Human Wharton?s jelly-derived stem cells display immunomodulatory properties and transiently improve rat experimental autoimmune encephalomyelitis.
In this study, we investigated whether WJ-MSCs possess the required properties to effectively and durably reverse these pathological hallmarks, and whether they survive in an inflammatory environment after transplantation. WJ-MSCs displayed a lowly immunogenic phenotype and showed intrinsic expression of neurotrophic factors and a variety of anti-inflammatory molecules. Furthermore, they dose-dependently suppressed proliferation of activated T cells using contact-dependent and paracrine mechanisms. Indoleamine 2,3-dioxygenase 1 was identified as one of the main effector molecules responsible for the observed T cell suppres...
Source: Cell Transplantation - October 10, 2014 Category: Cytology Authors: Donders R, Vanheusden M, Bogie JF, Ravanidis S, Thewissen K, Stinissen P, Gyselaers W, Hendriks JJ, Hellings N Tags: Cell Transplant Source Type: research

The Experimental Therapy on Brain Ischemia by Improvement of Local Angiogenesis with Tissue Engineering in The Mouse.
Abstract Neural restoration has proven to be difficult after brain stroke, especially in its chronic stage. This is mainly due to the generation of an unpropitious niche in the injured area, including loss of vascular support but production of numerous inhibitors against neuronal regeneration. Reconstruction of a proper niche for promoting local angiogenesis, therefore, should be a key approach for neural restoration after stroke. In the present study, a new biomaterial composite that could be implanted in injured area of the brain was created for experimental therapy of brain ischemia in the mouse. This composite...
Source: Cell Transplantation - October 9, 2014 Category: Cytology Authors: Ju R, Wen Y, Gou R, Wang Y, Xu Q Tags: Cell Transplant Source Type: research

Feasibility and Safety of Intraarterial Pericyte Progenitor Cell Delivery Following Mannitol-Induced Transient Blood?Brain Barrier Opening in a Canine Model.
Abstract Stem-cell therapy is currently being studied with a view to rescuing various neurological diseases. Such studies require not only the discovery of potent candidate cells, but also the development of methods that allow optimal delivery of those candidates to the brain tissues. Given that the blood?brain barrier (BBB) precludes cells from entering the brain, the present study was designed to test whether hyperosmolar mannitol securely opens the BBB and enhances intraarterial cell delivery. A noninjured normal canine model in which the BBB was presumed to be closed was used to evaluate the feasibility and sa...
Source: Cell Transplantation - June 13, 2014 Category: Cytology Authors: Youn SW, Jung KH, Chu K, Lee JY, Lee ST, Bahn JJ, Park DK, Yu JS, Kim SY, Kim M, Lee SK, Han MH, Roh JK Tags: Cell Transplant Source Type: research

The Use of ADSCs as a Treatment for Chronic Stroke.
Abstract Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, ...
Source: Cell Transplantation - May 17, 2014 Category: Cytology Authors: Chan TM, Harn HJ, Lin HP, Chiu SC, Lin PC, Wang HI, Ho LI, Chuu CP, Chiou TW, Hsieh AC, Chen YW, Ho WY, Lin SZ Tags: Cell Transplant Source Type: research

Direct reprogrammed neuronal cells as a novel resource for cell transplantation therapy.
Abstract Cell transplantation/ replacement therapy is attractive as a novel strategy for neurological diseases such as Parkinson?s disease, Alzheimer?s disease, and stroke. To realize this therapy, safer and more therapeutic effective cell resources are now required. Since induced pluripotent stem (iPS) cells can retain high replication competence and pluripotency when they differentiate into various kinds of cells, they are regarded as a promising cell source for cell transplantation therapy. However, high tumorigenesis of iPS has to be overcome for clinical applications. Recent progress includes the combination ...
Source: Cell Transplantation - March 11, 2014 Category: Cytology Authors: Yamashita T, Abe K Tags: Cell Transplant Source Type: research

Transplantation of human dental pulp-derived stem cells protects against heat stroke in mice.
In conclusion, post-WBH treatment with SHED reduced induction of pro-inflammatory cytokines and oxidative radicals, enhanced plasma induction of both adrenocorticotrophic hormone and corticosterone, and improved lethality in mice heat stroke. The protective effect of SHED may be related to a decreased inflammatory response, a decreased oxidative stress, and an increased hypothalamo-pituitaryadrenocortical axis activity following the WBH injury. PMID: 24612725 [PubMed - as supplied by publisher]
Source: Cell Transplantation - March 7, 2014 Category: Cytology Authors: Tseng LS, Chen SH, Lin MT, Lin YC Tags: Cell Transplant Source Type: research

BDNF Pre-treatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic-Ischemic Stroke.
Abstract Intra-arterial (IA) neural stem cell (NSC) therapy has the potential to improve long-term outcomes after stroke. Here we evaluate if pre-treatment of NSCs with brain derived neurotrophic factor (BDNF) prior to transplantation improves cell engraftment and functional recovery following hypoxic-ischemia (HI). Human embryonic-derived NSCs with or without BDNF pre-treatment (1 hour, 100ng/mL) were transplanted 3 days after HI. Functional recovery was assessed using the horizontal ladder test. Cell engraftment was evaluated using bioluminescence imaging (BLI) and histological counts of SC121(+) cells. Fluoro-J...
Source: Cell Transplantation - March 3, 2014 Category: Cytology Authors: Rosenblum S, Smith TN, Wang N, Chua JY, Westbroek E, Wang K, Guzman R Tags: Cell Transplant Source Type: research

Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats.
Abstract Intra-arterial (i.a.) delivery of bone marrow-derived mesenchymal stem cells (BMMSCs) has shown potential as a minimally invasive therapeutic approach for stroke. The aim of the present study was to determine the whole-body biodistribution and clearance of technetium-99m ((99m)Tc)-labeled rat and human BMMSCs after i.a. delivery in a rat model of transient middle cerebral artery occlusion (MCAO) using single photon emission computed tomography (SPECT). Our hypothesis was that xenotransplantation has a major impact upon the behavior of cells. Male RccHan:Wistar rats were subjected to sham-operation or MCAO...
Source: Cell Transplantation - March 3, 2014 Category: Cytology Authors: Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J Tags: Cell Transplant Source Type: research

Mannitol-enhanced delivery of stem cells and their growth factors across the blood brain barrier.
MANNITOL-ENHANCED DELIVERY OF STEM CELLS AND THEIR GROWTH FACTORS ACROSS THE BLOOD BRAIN BARRIER. Cell Transplant. 2014 Jan 29; Authors: Gonzales-Portillo GS, Sanberg PR, Franzblau M, Gonzales-Portillo C, Diamandis T, Staples M, Sanberg CD, Borlongan CV Abstract Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment, and hypothermia for cerebralpalsy. Due to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells includi...
Source: Cell Transplantation - January 29, 2014 Category: Cytology Authors: Gonzales-Portillo GS, Sanberg PR, Franzblau M, Gonzales-Portillo C, Diamandis T, Staples M, Sanberg CD, Borlongan CV Tags: Cell Transplant Source Type: research

Intracerebral Implantation of Autologous Peripheral Blood Stem Cells in Stroke Patients: a Randomized Phase II Study.
Abstract In our previous study, intracerebral implantation of peripheral blood stem cells (PBSC) improved functional outcome in rats with chronic cerebral infarction. Based on this findings, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n=15) and control group (n=15)] with middle cerebral artery infarction confirmed on T2?weighted MRI 6 months to 5 years after a stroke. Only subjects with neurological deficits of intermediate severity based on the National Institute of Health Stroke Scale (NIHSS) (range: 9?20) that had been stable for at least 3 months were enrolled. Those i...
Source: Cell Transplantation - January 29, 2014 Category: Cytology Authors: Chen DC, Lin SZ, Fan JR, Lin CH, Lee W, Lin CC, Liu YJ, Tsai CH, Chen JC, Cho DY, Lee CC, Shyu WC Tags: Cell Transplant Source Type: research

Long-term effects of magnetically-targeted ferumoxide-labeled human neural stem cells in focal cerebral ischemia.
Abstract The long-term effect of magnetically-targeted neural stem cells in a rat focal cerebral ischemia model was investigated. In middle cerebral artery occlusion (MCAo) stroke model rats, ferumoxide-labeled human neural stem cells (NSCs) were injected into the tail vein. MCAo rats were divided into three groups: ischemia only (IO), ischemia with NSC injection (IC), and ischemia with NSC injection and the use of magnet targeting (IM). Four weeks after MCAo and 3 weeks post-transplantation, greater number of hNSCs were found in ischemic lesion site inIM rat brain as compared with IO and IC animals. In addition, ...
Source: Cell Transplantation - December 30, 2013 Category: Cytology Authors: Song M, Kim YJ, Kim YH, Roh J, Kim EC, Lee HJ, Kim SU, Yoon BW Tags: Cell Transplant Source Type: research

Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke.
This study provides valuable insights into the effect of BMC transplantation in the chronic ischemic brain, which lead to the development of effective therapy for chronic stroke patients who currently lack satisfactory therapeutic options. PMID: 24152766 [PubMed - as supplied by publisher]
Source: Cell Transplantation - October 22, 2013 Category: Cytology Authors: Yoo J, Seo JJ, Eom JH, Hwang DY Tags: Cell Transplant Source Type: research