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Source: Journal of Neuroimmunology
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Total 89 results found since Jan 2013.
Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly
Stroke is the leading cause of death and the main cause of disability in surviving patients. The detrimental interaction between immune cells, glial cells, and matrix components in stroke pathology results in persistent inflammation that progresses to fibrosis. A substantial effort is being directed toward understanding the exact neuroinflammatory events that take place as a result of stroke. The initiation of a potent cytokine response, along with immune cell activation and infiltration in the ischemic core, has massive acute deleterious effects, generally exacerbated by comorbid inflammatory conditions.
Source: Journal of Neuroimmunology - July 7, 2020 Category: Allergy & Immunology Authors: Narayanappa Amruta, Abir Rahman, Emmanuel Pinteaux, Gregory Bix Tags: Review Article Source Type: research
Post-stroke inflammatory response is linked to volume loss in the contralateral hemisphere
In this study, we assessed the magnitude of cerebral volume loss in the unaffected contralateral hemisphere following stroke, and determined its relationship with inflammatory cascades.
Source: Journal of Neuroimmunology - April 20, 2020 Category: Allergy & Immunology Authors: Serhat V. Okar, Mehmet A. Topcuoglu, Muge Yemisci, Canan Cakir Aktas, Kader K. Oguz, Ethem M. Arsava Source Type: research
An ischemic stroke as the presenting manifestation of rapidly progressive primary angiitis of central nervous system in a 17-year-old boy
Childhood primary angiitis of the central nervous system (cPACNS) is an increasingly recognized inflammatory brain disease in children.
Source: Journal of Neuroimmunology - February 12, 2020 Category: Allergy & Immunology Authors: Zinovia-Maria Kefalopoulou, Stamatis-Nick Liossis, Theodora Sagona, Dimitra Veltsista, Petros Zampakis, Pantelis Kraniotis, Aikaterini Solomou, John Ellul, Elisabeth Chroni Tags: Short Communication Source Type: research
Data inclusion in the article: A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke
Recently we took great interest to read a meta-analysis by Chen and his colleagues presenting the association of IL-6 and IL-10 polymorphisms with ischemic stroke (IS) susceptibility. The author found that IL-6 rs1800795 polymorphism was significantly associated with susceptibility to IS in Asians, but not in Caucasians(Chen and Yang, 2019). It's a very significant study. However, there are some questions about the data inclusion of this meta-analysis we would like to communicate with the authors.
Source: Journal of Neuroimmunology - December 18, 2019 Category: Allergy & Immunology Authors: Dongmei Huang Tags: Letter to the editor Source Type: research
A challenging diagnosis of reversible “vascular” dementia: Cerebral amyloid angiopathy-related inflammation
We describe the clinical course, radiological features and therapeutic approach of two patients with probable CAA-ri with the aim of emphasizing the importance of an early diagnosis of this potentially reversible disease in different neurological settings, such as memory clinics and stroke units.
Source: Journal of Neuroimmunology - November 6, 2019 Category: Allergy & Immunology Authors: L. Poli, V. De Giuli, F. Piazza, I. Volonghi, G. Bigliardi, S. Vallone, P.F. Nichelli, R. Gasparotti, A. Zini, A. Padovani, A. Pezzini Tags: Short Communication Source Type: research
A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke
Some previous studies already explored associations of interleukin-6 (IL-6) and interleukin-10 (IL-10) polymorphisms with ischemic stroke (IS). However, the results were conflicting. In this meta-analysis, we aimed to better analyze the relationship between IL-6/IL-10 polymorphisms and IS in a larger pooled population.
Source: Journal of Neuroimmunology - July 8, 2019 Category: Allergy & Immunology Authors: Miao Chen, Yue Yang Source Type: research
The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke
The splenic T-cell immune response to stroke has been identified as an important role in the progression of brain injury following ischemic stroke. Interleukin (IL)-33 as a novel cytokine of IL-1 family has been found to be protective for ischemic brain injury. Here, we determined the contribution of IL-33 to the T-cell immune responses in the spleen after experimental ischemic stroke. Mice were subjected to 30 min of middle cerebral artery occlusion (MCAO) for ischemic stroke induction. Recombinant mouse IL-33 (100 μg/kg) was pre-treated intraperitoneally at 30 min prior to MCAO, then the percentages of T cell sub...
Source: Journal of Neuroimmunology - May 26, 2019 Category: Allergy & Immunology Authors: Wei Xiao, Shuang Guo, Lin Chen, Yi Luo Source Type: research
Prognostic value of copeptin in patients with aneurysmal subarachnoid hemorrhage
This study investigated the prognostic value of copeptin in the patients with aneurysmal subarachnoid hemorrhage(aSAH).
Source: Journal of Neuroimmunology - March 7, 2019 Category: Allergy & Immunology Authors: Zhizhi Zuo, Xiang Ji Source Type: research
Rheumatoid meningitis sine arthritis
We present a case of a 7()year-old female with no history of arthritis who developed stroke-like symptoms, seizures, psychosis and compulsive behavior. Serial brain magnetic resonance images (MRI) over four months demonstrated progressive interhemispheric meningeal thickening. She had mild lymphocytic pleocytosis on the cerebrospinal fluid analysis and serum anti-cyclic citrullinated peptide antibodies resulted positive in high titers.
Source: Journal of Neuroimmunology - December 19, 2018 Category: Allergy & Immunology Authors: Cathy Lee Ching, Lawrence Kenyon, Matthew Berk, Chantel Park Source Type: research
T cells in the post-ischemic brain: Troopers or paramedics?
The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Recently, a critical role for T cells has also become more evident for the chronic phase after stroke in modulating delayed neuronal (dys-) function and recovery.
Source: Journal of Neuroimmunology - November 13, 2018 Category: Allergy & Immunology Authors: Julia V. Cramer, Corinne Benakis, Arthur Liesz Tags: Review Article Source Type: research
The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation
Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction.
Source: Journal of Neuroimmunology - October 25, 2018 Category: Allergy & Immunology Authors: Peter Ludewig, Jack Winneberger, Tim Magnus Tags: Review Article Source Type: research
Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia
Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal necrosis and degeneration were significantly more intense in the core, whereas inflammatory infiltration, MPO, CD68, CD3, FXIII, Cox-2, iNOS2, Arg-1 expressions were stronger in the penumbra.
Source: Journal of Neuroimmunology - August 9, 2018 Category: Allergy & Immunology Authors: Em őke Horváth, Adina Hutanu, Liviu Chiriac, Minodora Dobreanu, Alex Orădan, Előd-Ernő Nagy Source Type: research
Neuroinflammatory responses in experimental and human stroke lesions
Neuroinflammation has been suggested as an attractive treatment target in stroke, since it offers a broader therapeutic window in comparison to currently established thrombolytic approaches. Inflammatory cells of both the innate and the adaptive immune system have been identified in experimental as well as human stroke lesions. In animal models, various therapeutic strategies targeting neuroinflammation have shown beneficial effects, however, translation to human disease has so far been disappointing.
Source: Journal of Neuroimmunology - July 6, 2018 Category: Allergy & Immunology Authors: Isabella Wimmer, Tobias Zrzavy, Hans Lassmann Tags: Review Source Type: research
Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke
To investigate if oxymatrine could ameliorate hippocampus ischemia/reperfusion (I/R) injury induced in rats and explore the possible mechanism. Rats were randomly divided into four groups: sham group, I/R group, I/R + OMT-treated group, I/R + Vehicle-treated group. Oxymatrine or vehicle solution was intraperitoneally injected OMT (150 mg/kg) 60 min before renal ischemia respectively. Water maze was measured; cell apoptosis was assessed by doing TUNEL assay and detecting the expression of P53, Bax, and Cleaved-Caspase-3; autophagy were assessed by measuring the expression of LC3 and P62.
Source: Journal of Neuroimmunology - July 2, 2018 Category: Allergy & Immunology Authors: Shuhu Zhou, Baojun Qiao, Xu Chu, Baojun Qiao, Qingxia Kong Tags: Review Article Source Type: research
Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease
Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leucocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patients with multiple sclerosis, ischemic stroke, and somatoform disorders (n = 18 per group). Changes in the intrathecal immune-cell profile were heterogeneous in PACNS. While proportions of T-cell subsets remained unaltered, some PACNS patients showed a shift toward NK- or B cells.
Source: Journal of Neuroimmunology - June 6, 2018 Category: Allergy & Immunology Authors: Daniel Strunk, Andreas Schulte-Mecklenbeck, Kristin S. Golombeck, Gerd Meyer zu H örste, Nico Melzer, Carolin Beuker, Antje Schmidt, Heinz Wiendl, Sven G. Meuth, Catharina C. Gross, Jens Minnerup Source Type: research
