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Hyaluronic acid and Regenerative medicine: New insights into the stroke therapy.
Abstract Stroke is known as one of very important public health problems which are related to a societal burden and tremendous economic. It has been showed, there are few therapeutic approaches in the treatment of this disease. In this regard, present therapeutic platforms aim to obtain neuroprotection, reperfusion, and neurorecovery. Among these therapies, regenerative medicine-based therapies have been appeared as new ways in stroke therapy. Hyaluronic acid (HA) is a new candidate which could be applied as regerenative medicine-based therapy in the treatment of stroke. HA is a glycosaminoglycan which is formed o...
Source: Current Molecular Medicine - March 24, 2020 Category: Molecular Biology Authors: Shahi M, Mohammadnejad D, Karimipour M, Rasta SH, Rahbarghazi R, Elahi AA Tags: Curr Mol Med Source Type: research

Transgenic Overproduction of Omega-3 Polyunsaturated Fatty Acids Provides Neuroprotection and Enhances Endogenous Neurogenesis after Stroke.
Abstract Strokes are devastating as there are no current therapies to prevent the long term neurological deficits that they cause. Soon after ischemic stroke, there is proliferation and differentiation of neural stem/progenitor cells as an important mechanism for neuronal restoration. However, endogenous neurogenesis by itself is insufficient for effective brain repair after stroke as most newborn neurons do not survive. One fascinating strategy for stroke treatment would thus be maintaining the survival and/or promoting the differentiation of endogenous neural stem/progenitor cells. Using transgenic (Tg) mice ove...
Source: Current Molecular Medicine - August 22, 2013 Category: Molecular Biology Authors: Hu X, Zhang F, Leak RK, Zhang W, Iwai M, Stetler RA, Dai Y, Zhao A, Gao Y, Chen J Tags: Curr Mol Med Source Type: research

Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
Curr Mol Med. 2023 Apr 10. doi: 10.2174/1566524023666230410101724. Online ahead of print.ABSTRACTIschemic stroke is one of the major causes of global mortality, which puts great demands on health systems and social welfare. Ischemic stroke is a complex pathological process involving a series of mechanisms such as ROS accumulation, Ca2 + overload, inflammation, and apoptosis. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients has led scientists to find new treatments. The use of herbal medicine, as an alternative or complementary therapy, is increasing worldwide. For centurie...
Source: Current Molecular Medicine - April 11, 2023 Category: Molecular Biology Authors: Shakiba Azami Fatemeh Forouzanfar Source Type: research

Common Genetic Conditions of Ischemic Stroke to Keep in Mind.
Abstract Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach. PMID: 2532387...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Mancuso M, Orsucci D, Ienco EC, Brondi M, Simoncini C, Chiti A, Montano V, Terni E, Giannini N, Siciliano G, Bonuccelli U Tags: Curr Mol Med Source Type: research

The Multiple Aspects of Stroke and Stem Cell Therapy.
Abstract Cumulative evidence shows that transplantation of stem cells (SC) derivatives can reduce the functional deficits induced by cerebral ischemia or hemorrhage in animals. Most SC sources have been applied to stroke models, with varying degrees of differentiation into neural derivatives and in varying number, timing and route of administration, with similar benefits on functional outcome. Pioneering clinical trials developed in parallel, and currently outnumber other applications of SC in neurological disorders. These trials reflect a paradigm shift from cell replacement therapy to disease-modeling effects, w...
Source: Current Molecular Medicine - May 2, 2013 Category: Molecular Biology Authors: Onteniente B Tags: Curr Mol Med Source Type: research

Matrix Metalloproteinase Inhibition in Atherosclerosis and Stroke.
Abstract Matrix metalloproteinases (MMPs) are a family of tightly regulated, zinc-dependent proteases that degrade extracellular matrix (ECM), cell surface, and intracellular proteins. Vascular remodeling, whether as a function of normal physiology or as a consequence of a myriad of pathological processes, requires degradation of the ECM. Thus, the expression and activity of many MMPs is up-regulated in numerous conditions affecting the vasculature and often exacerbate vascular dysfunction. A growing body of evidence supports the rationale of using MMP inhibitors for the treatment of cardiovascular diseases, strok...
Source: Current Molecular Medicine - July 16, 2013 Category: Molecular Biology Authors: Roycik MD, Myers JS, Newcomer RG, Sang QX Tags: Curr Mol Med Source Type: research

Identification of phosphorylation associated SNPs for blood pressure, coronary artery disease and stroke from genome-wide association studies.
CONCLUSION: The findings suggested that phosSNPs may play important roles in the pathological mechanisms of cardiovascular diseases. PMID: 31456518 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - August 27, 2019 Category: Molecular Biology Authors: Wang X, Mo X, Zhang H, Zhang Y, Shen Y Tags: Curr Mol Med Source Type: research

Ipsilateral Hippocampal Proteomics Reveals Mitochondrial Antioxidative Stress Impairment in Cortical-Lesioned Chronic Mild Stressed Rats.
In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a left anterior cortical lesion followed by chronic mild stress (CMS) for three weeks. Through sucrose preference testing, PSD rats displayed depression-like behavior during the entire CMS period. In contrast, stroke rats displayed depression-like behavior in the first week post-stroke and recovered in the second w...
Source: Current Molecular Medicine - October 21, 2014 Category: Molecular Biology Authors: Pan J, Liu H, Zhou J, Liu Z, Yang Y, Peng Y, You H, Yang D, Xie P Tags: Curr Mol Med Source Type: research

The Yin and Yang of Inflammation.
Abstract Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach. PMID: 2532399...
Source: Current Molecular Medicine - October 15, 2014 Category: Molecular Biology Authors: Blackman MA, Yates JL, Spencer CM, Vomhof-DeKrey EE, Cooper AM, Leadbetter EA Tags: Curr Mol Med Source Type: research

Clinical Assessment of Carotid Atherosclerosis Inflammation by Positron Emission Tomography.
Abstract Stroke caused by carotid atherosclerosis is a leading cause of mortality and the leading cause of disability in the developed world. For carotid plaques within the neurovascular territory of a recent stroke or transient ischaemic attack, surgical removal of the plaque (endarterectomy) has been clearly shown to reduce future cerebrovascular events. Management of asymptomatic plaques, however, is less clear because only a minority of these plaques will ultimately become symptomatic. Inflammation is a key feature which predicts whether a plaque is likely to rupture and hence lead to stroke. By identifying in...
Source: Current Molecular Medicine - November 11, 2013 Category: Molecular Biology Authors: Shalhoub J, Oskrochi Y, H Davies A, R J Owen D Tags: Curr Mol Med Source Type: research

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