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The physiological/pathophysiological significance of Vitamin D in cancer, cardiovascular disorders and beyond.
Abstract Vitamin D, a molecular precursor of the potent steroid hormone calcitriol, has a crucial functions and roles in physiology and pathophysiology. Tellingly, Calcitriol has been shown to regulate various cellular signalling networks and cascades that have crucial role in cancer biology and diagnostics. Mounting lines of evidences from previous clinical and preclinical investigations indicate that the deficiency of vitamin D may contribute to the carcinogenesis risk. Concomitantly, recent reports suggested that significant reduction in the cancer occurrence and progression is more likely to appear after vitam...
Source: Current Drug Metabolism - December 6, 2016 Category: Drugs & Pharmacology Authors: AlMatar M, AlMandeal H, Makky EA, Kayar B, Yarar E, Var I, Köksal F Tags: Curr Drug Metab Source Type: research