• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

In reply —Risk Framing in Cardiovascular Medicine I and II
We thank the authors for their insightful comments on our perspective published in the journal.1 We agree with Dr Modarressi1 that sodium-glucose cotransporter-2 inhibitors indeed represent an important new treatment for patients with heart failure. Although we used the trial definition of major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or stroke) in the text and in the table ’s footnote, we acknowledge that this was a secondary and not a primary end point.
Source: Mayo Clinic Proceedings - November 1, 2020 Category: Internal Medicine Authors: Mohamad Alkhouli, Charanjit S. Rihal Tags: Letter to the editor Source Type: research

Low-Sodium Intake: A Risk Factor for Stroke?
The recent findings by Kieneker et  al1 represent the first convincing evidence that a low sodium intake might be linked to an increased cerebrovascular risk. The highly cited papers by a Canadian group2 already claimed to show a sort of J-shaped association between sodium intake and cardiovascular events, but there are limitations to these studies, as has been discussed previously.3
Source: Mayo Clinic Proceedings - March 31, 2019 Category: Internal Medicine Authors: Natale Musso, Andrea Dotto Tags: Letter to the Editor Source Type: research

In reply —Low-Sodium Intake: A Risk Factor for Stroke?
We are grateful to Drs Musso and Dotto1 for the appraisal of our article on low urinary sodium excretion (UNaV) as an indicator of low sodium intake and increased risk of stroke.2 We agree that the mentioned earlier study by O ’Donnell and colleagues,3 although representative of various populations by including more than 100,000 participants from 17 countries, has some limitations. In particular, the assessment of sodium intake via a single spot urine sample is a major limitation. Actual measurement of 24-hour UNaV in m ultiple urine collections (to account for day-to-day variability), as we did in the Prevention of Rena...
Source: Mayo Clinic Proceedings - March 31, 2019 Category: Internal Medicine Authors: Lyanne M. Kieneker, Michele F. Eisenga, Stephan J.L. Bakker Tags: Letter to the Editor Source Type: research

Association of Low Urinary Sodium Excretion With Increased Risk of Stroke
We examined the association of urinary sodium excretion (UNaV) as an accurate estimate of intake with risk of stroke. We studied 7330 individuals free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, a prospective, population-based cohort of Dutch men and women.
Source: Mayo Clinic Proceedings - September 20, 2018 Category: Internal Medicine Authors: Lyanne M. Kieneker, Michele F. Eisenga, Ron T. Gansevoort, Rudolf A. de Boer, Gerjan Navis, Robin P.F. Dullaart, Michel M. Joosten, Stephan J.L. Bakker Tags: Brief report Source Type: research