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Specialty: Geriatrics
Source: Neurobiology of Aging

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Total 38 results found since Jan 2013.

Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.
Abstract Oxidative DNA damage is mainly repaired by base excision repair (BER). Previously, our laboratory showed that mice lacking the BER glycosylases 8-oxoguanine glycosylase 1 (Ogg1) or nei endonuclease VIII-like 1 (Neil1) recover more poorly from focal ischemic stroke than wild-type mice. Here, a mouse model was used to investigate whether loss of 1 of the 2 alleles of X-ray repair cross-complementing protein 1 (Xrcc1), which encodes a nonenzymatic scaffold protein required for BER, alters recovery from stroke. Ischemia and reperfusion caused higher brain damage and lower functional recovery in Xrcc1(+/-) mi...
Source: Neurobiology of Aging - April 17, 2015 Category: Geriatrics Authors: Ghosh S, Canugovi C, Yoon JS, Wilson DM, Croteau DL, Mattson MP, Bohr VA Tags: Neurobiol Aging Source Type: research

Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.
Abstract Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength. Once proficient, rats receiv...
Source: Neurobiology of Aging - June 4, 2016 Category: Geriatrics Authors: Hays SA, Ruiz A, Bethea T, Khodaparast N, Carmel JB, Rennaker RL, Kilgard MP Tags: Neurobiol Aging Source Type: research

Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged  rats.
Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged rats. Neurobiol Aging. 2018 Jun 11;70:102-116 Authors: Zhou YF, Li PC, Wu JH, Haslam JA, Mao L, Xia YP, He QW, Wang XX, Lei H, Lan XL, Miao QR, Yue ZY, Li YN, Hu B Abstract Brain tissue survival and functional recovery after ischemic stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in the ischemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has been demonstrated to be a critical regulator in embryoni...
Source: Neurobiology of Aging - June 11, 2018 Category: Geriatrics Authors: Zhou YF, Li PC, Wu JH, Haslam JA, Mao L, Xia YP, He QW, Wang XX, Lei H, Lan XL, Miao QR, Yue ZY, Li YN, Hu B Tags: Neurobiol Aging Source Type: research

Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study
Neurobiol Aging. 2021 Feb 21;102:161-169. doi: 10.1016/j.neurobiolaging.2021.02.010. Online ahead of print.ABSTRACTTo establish causal evidence for the association of adiposity-related metabolic abnormalities with brain volumes, and the risks of dementia and stroke, we applied 1- and 2-sample Mendelian randomization (MR) analyses using up to 336,309 UK Biobank participants. We used 3 classes of genetic instruments, which all increase body mass index but are associated with different metabolic profiles (unfavorable, neutral and favorable). We validated the instruments using anthropometric and cardio-metabolic traits. Both m...
Source: Neurobiology of Aging - March 26, 2021 Category: Geriatrics Authors: Anwar Mulugeta Amanda Lumsden Elina Hypp önen Source Type: research

Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Neurobiol Aging. 2023 May 5;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Online ahead of print.ABSTRACTStroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injections of miR-20a-3p, a small noncoding RNA (miRNA) delivered after stroke improves acute stroke outcomes in middle-aged male and female rats. The present study tested whether mir-20a-3p treatment would also ameliorate stroke-induced cognitive decline in the chronic phase. Acyclic...
Source: Neurobiology of Aging - June 19, 2023 Category: Geriatrics Authors: Dayalan Sampath Taylor E Branyan Kylee G Markowsky Rithvik Gunda Nadia Samiya Andre Obenaus Farida Sohrabji Source Type: research

High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage.
We examined the longitudinal relationship of dPVS burden with risk of incident stroke, ischemic stroke, and intracerebral hemorrhage (ICH) in the 3C-Dijon population-based study (N = 1678 participants, mean age 72.7 ± 4.1 years) using Cox regression. dPVS burden was studied as a global score and according to dPVS location (basal ganglia, white matter, hippocampus, brainstem) at the baseline. During a mean follow-up of 9.1 ± 2.6 years, 66 participants suffered an incident stroke. Increasing global dPVS burden was associated with a higher risk of any incident stroke (hazard ratio [HR], 1.24; 95% CI, [1.06-1.45]) and of ...
Source: Neurobiology of Aging - September 9, 2019 Category: Geriatrics Authors: Duperron MG, Tzourio C, Schilling S, Zhu YC, Soumaré A, Mazoyer B, Debette S Tags: Neurobiol Aging Source Type: research

Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice.
In this study, we investigated the effects of resveratrol on inflammation in visceral adipose tissue and the brain and its effects on ischemic brain injury in aged female mice. Mice treated with resveratrol (0.1 mg/kg, p.o.) for 10 days showed reduced levels of interleukin-1β and tumor necrosis factor-α, as well as a reduction in the size of adipocytes in visceral adipose tissue. Resveratrol also reduced interleukin-1β and tumor necrosis factor-α protein levels and immunoglobulin G extravasation in the brain. Mice treated with resveratrol demonstrated smaller infarct size, improved neurological function, and blunted ...
Source: Neurobiology of Aging - June 20, 2016 Category: Geriatrics Authors: Jeong SI, Shin JA, Cho S, Kim HW, Lee JY, Kang JL, Park EM Tags: Neurobiol Aging Source Type: research

A suggested shared aetiology of dementia - a colocalization study
Neurobiol Aging. 2022 May 13;117:71-82. doi: 10.1016/j.neurobiolaging.2022.05.005. Online ahead of print.ABSTRACTIdentification of shared causal genes between dementia and its related clinical outcomes can help understand shared aetiology and multimorbidity surrounding dementia. We performed the HyPrColoc colocalization analysis to detect possible shared causal genes between dementia or Alzheimer's disease (AD) and 5 selected traits: stroke, diabetes, atherosclerosis, cholesterol level, and alcohol consumption within 601 dementia or AD associated genetic regions using summary results of the UK Biobank genome-wide associati...
Source: Neurobiology of Aging - June 8, 2022 Category: Geriatrics Authors: Xinzhu Yu Artitaya Lophatananon Krisztina Mekli Alistair Burns Kenneth R Muir Hui Guo Source Type: research

Vision and proprioception in action monitoring by young and older adults.
This study investigated the individual's capability to discriminate the directions of seen cursor motions and felt hand movements under a visuo-motor rotation paradigm and its age-related variation. Young and older participants performed 3-stroke arm movements on a digitizing tablet without seeing their arm. The visual feedback of the second stroke was rotated randomly by various angles ranging from -30° to 30° and displayed on a monitor. Older adults were poorer in discrimination than young adults. In both age groups, the felt hand direction was shifted toward the seen cursor direction (i.e., visual capture) by approxi...
Source: Neurobiology of Aging - February 20, 2013 Category: Geriatrics Authors: Rand MK, Wang L, Müsseler J, Heuer H Tags: Neurobiol Aging Source Type: research

Twenty-four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats.
Abstract Stroke is a major cause of disability for which no neuroprotective measures are available. Age is the principal nonmodifiable risk factor for this disease. Previously, we reported that exposure to hydrogen sulfide for 48 hours after stroke lowers whole body temperature and confers neuroprotection in aged animals. Because the duration of hypothermia in most clinical trials is between 24 and 48 hours, we questioned whether 24 hours exposure to gaseous hypothermia confers the same neuroprotective efficacy as 48 hours exposure. We found that a shorter exposure to hypothermia transiently reduced both infla...
Source: Neurobiology of Aging - February 1, 2016 Category: Geriatrics Authors: Sandu RE, Buga AM, Balseanu AT, Moldovan M, Popa-Wagner A Tags: Neurobiol Aging Source Type: research

Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias.
Abstract Both the inflammatory potential and cognitive function decline during aging. The association between the repertoire of inflammatory biomarkers and cognitive decline is unclear. Inflammatory cytokines have been reported to be increased, decreased, or unchanged in the cerebrospinal fluid and sera of subjects with dementia. We assessed 112 postmortem brains from subjects diagnosed with poststroke dementia (PSD), vascular dementia, mixed dementia, and Alzheimer's disease (AD), comparing those to poststroke nondemented (PSND) subjects and age-matched controls. We analyzed 5 brain regions including the gray and...
Source: Neurobiology of Aging - February 1, 2016 Category: Geriatrics Authors: Chen A, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN Tags: Neurobiol Aging Source Type: research

Mitochondrial DNA m.3243A > G mutation rarely causes CADASIL-like phenotype.
Mitochondrial DNA m.3243A>G mutation rarely causes CADASIL-like phenotype. Neurobiol Aging. 2020 Aug 27;: Authors: Liao NY, Liao KK, Liao YC, Lee YC Abstract Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are 2 monogenic cerebral small vessel diseases sharing several common clinical features including young stroke, migraine, and cognitive dysfunction. The aim of this study was to understand the role of MELAS in patients with CADASIL-like manifestations. We scr...
Source: Neurobiology of Aging - August 26, 2020 Category: Geriatrics Authors: Liao NY, Liao KK, Liao YC, Lee YC Tags: Neurobiol Aging Source Type: research

Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease
Neurobiol Aging. 2021 Jun 21;106:130-138. doi: 10.1016/j.neurobiolaging.2021.06.013. Online ahead of print.ABSTRACTRaised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical relevance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demographics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n=44; mild stroke patients, n=105; older community-dwelling participants from Lothian birth cohort 193...
Source: Neurobiology of Aging - July 18, 2021 Category: Geriatrics Authors: Jun-Fang Zhang Hwee Fang Lim Francesca M Chappell Una Clancy Stewart Wiseman Maria C Vald és-Hernández Daniela Jaime Garcia Mark E Bastin Fergus N Doubal Will Hewins Simon R Cox Susana Mu ñoz Maniega Michael Thrippleton Michael Stringer Charlotte Jardi Source Type: research