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Specialty: Neurology
Source: Der Nervenarzt

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Total 213 results found since Jan 2013.

Drugs for improvement of motor deficits after stroke.
Abstract Randomized controlled trials with a variety of drugs have been performed for approximately 20 years in order to support functional restitution of motor deficits after a stroke. Nowadays, serotonin reuptake inhibitors show the highest level of evidence due to the largest number of positive studies and L‑dopa also seems to be effective; however, much fewer studies have been conducted. In the majority of trials amphetamines provided no additional benefits and D‑cycloserine cannot be recommended either. Future therapeutic approaches, e.g. anti-nogo antibodies and cell therapy are presented. PMID: 2...
Source: Der Nervenarzt - September 13, 2016 Category: Neurology Authors: Liepert J Tags: Nervenarzt Source Type: research

Neurofeedback-based motor imagery training for rehabilitation after stroke.
Abstract Mental training, including motor observation and motor imagery, has awakened much academic interest. The presumed functional equivalence of motor imagery and motor execution has given hope that mental training could be used for motor rehabilitation after a stroke. Results obtained from randomized controlled trials have shown mixed results. Approximately half of the studies demonstrate positive effects of motor imagery training but the rest do not show an additional benefit. Possible reasons why motor imagery training has so far not become established as a robust therapeutic approach are discussed in detai...
Source: Der Nervenarzt - August 29, 2016 Category: Neurology Authors: Dettmers C, Braun N, Büsching I, Hassa T, Debener S, Liepert J Tags: Nervenarzt Source Type: research

Evidence-based rehabilitation of mobility after stroke.
DISCUSSION: These guidelines not only provide recommendations for action but also provide pathophysiological insights into functional restoration of stance and gait after stroke. PMID: 27531212 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - August 15, 2016 Category: Neurology Authors: Dohle C, Tholen R, Wittenberg H, Quintern J, Saal S, Stephan KM Tags: Nervenarzt Source Type: research

Arm rehabilitation : Current concepts and therapeutic options.
DISCUSSION: Several therapeutic procedures with proven efficacy are currently available for arm rehabilitation after stroke. Their differential indications are presented and associated with conclusions for clinical practice. PMID: 27531207 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - August 15, 2016 Category: Neurology Authors: Platz T, Schmuck L Tags: Nervenarzt Source Type: research

Stroke Summer School 2016 in M ühlheim : Über 80 Teilnehmer und etwa 40 Referenten vertieften aktuelle Schlaganfallthemen.
Stroke Summer School 2016 in Mühlheim : Über 80 Teilnehmer und etwa 40 Referenten vertieften aktuelle Schlaganfallthemen. Nervenarzt. 2016 Aug 1; Authors: PMID: 27481505 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - July 31, 2016 Category: Neurology Tags: Nervenarzt Source Type: research

Crew resource management and simulator training in acute stroke therapy.
CONCLUSION: Even though our data do not allow positive effects on patient outcomes to be inferred, the implementation of a CRM-based stroke team and simulator training has had multiple positive effects on the workflow and work satisfaction in the treatment of acute stroke patients. PMID: 27431675 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - July 17, 2016 Category: Neurology Authors: Tahtali D, Bohmann F, Rostek P, Misselwitz B, Reihs A, Heringer F, Jahnke K, Steinmetz H, Pfeilschifter W Tags: Nervenarzt Source Type: research

Invasive stroke treatment - Study results and clinical routine : Lost in translation?
CONCLUSION: Only careful analysis of study results and the background circumstances will enable adequate organization and successful practical implementation of this highly effective therapy in the clinical routine. Regional conditions have to be considered and will be crucial in this context. PMID: 27357456 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - June 28, 2016 Category: Neurology Authors: Breuer L, Schwab S, Köhrmann M Tags: Nervenarzt Source Type: research

Specialized neurological neurosurgical intensive care medicine.
Abstract In Germany dedicated neurological-neurosurgical critical care (NCC) is the fastest growing specialty and one of the five big disciplines integrated within the German critical care society (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin; DIVI). High-quality investigations based on resilient evidence have underlined the need for technical advances, timely optimization of therapeutic procedures, and multidisciplinary team-work to treat those critically ill patients. This evolution has repeatedly raised questions, whether NCC-units should be run independently or better be incorporat...
Source: Der Nervenarzt - May 19, 2016 Category: Neurology Authors: Kuramatsu JB, Huttner HB, Schwab S Tags: Nervenarzt Source Type: research

Focal point emergency departments.
Abstract The number of patients treated in hospital emergency departments in Germany has risen in recent years to approximately 20 million. This escalation also applies to the increasing numbers of patients presenting with neurological symptoms and diseases, which occur in approximately 20 % of emergency patients. In addition to patients with stroke, inflammatory or degenerative central nervous system (CNS) and peripheral nervous system (PNS) disorders who need urgent treatment, more and more patients with nonspecific complaints or conditions attend emergency departments for elective treatment, not least becaus...
Source: Der Nervenarzt - May 10, 2016 Category: Neurology Authors: Lange R, Popp S, Erbguth F Tags: Nervenarzt Source Type: research

Non-invasive brain stimulation in neurology : Transcranial direct current stimulation to enhance cognitive functioning.
Abstract Transcranial direct current stimulation (tDCS) has been successfully used in neuroscientific research to modulate cognitive functions. Recent studies suggested that improvement of behavioral performance is associated with tDCS-induced modulation of neuronal activity and connectivity. Thus, tDCS may also represent a promising tool for reconstitution of cognitive functions in the context of memory decline related to Alzheimer's disease or aphasia following stroke; however, evidence from randomized sham-controlled clinical trials is still scarce. Initial results of tDCS-induced behavioral improvement in pati...
Source: Der Nervenarzt - May 10, 2016 Category: Neurology Authors: Antonenko D, Flöel A Tags: Nervenarzt Source Type: research

Geriatrics - an interdisciplinary challenge.
Abstract The care of elderly patients will continue to challenge the healthcare system over the next decades. As a rule geriatric patients suffer from multimorbidities with complex disease patterns, and the ability to cope with everyday life is severely reduced. Treatment is provided by a multiprofessional geriatric team, and the primary goal is improvement of functional status, quality of life in the social environment and autonomy by employing a holistic approach. In Germany geriatric care is provided by physicians from various medical specialties (e.g. general practitioners, internists, neurologists and psychia...
Source: Der Nervenarzt - May 10, 2016 Category: Neurology Authors: Nau R, Djukic M, Wappler M Tags: Nervenarzt Source Type: research

Organized Post-Stroke Care through Case Management on the Basis of a Standardized Treatment Pathway : Results of a Single-Centre Pilot Study.
CONCLUSIONS: Our pilot data demonstrate that case management-based post-stroke care is feasible and may contribute to effective secondary prevention of stroke. PMID: 27072795 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - April 11, 2016 Category: Neurology Authors: Barlinn J, Barlinn K, Helbig U, Siepmann T, Pallesen LP, Urban H, Pütz V, Schmitt J, Reichmann H, Bodechtel U Tags: Nervenarzt Source Type: research

Endovascular stroke treatment following recent positive clinical trials.
Abstract Recently, five independent randomized controlled clinical trials demonstrated the efficacy and safety of endovascular stroke treatment in stroke patients with occlusion of proximal intracranial arteries. The five trials MR CLEAN, ESCAPE, EXTEND-IA, SWIFT-PRIME and REVASCAT randomized a total of 1287 stroke patients to either standard treatment, which in the majority of patients consisted of intravenous thrombolysis within 4.5 h of symptom onset or additional endovascular stroke treatment. In all the studies endovascular treatment resulted in a better clinical outcome with an odds ratio for a better clini...
Source: Der Nervenarzt - December 8, 2015 Category: Neurology Authors: Thomalla G, Fiehler J Tags: Nervenarzt Source Type: research

"Time is brain" in relapsing remitting multiple sclerosis : Current treatment concepts in immunotherapy.
DISCUSSION: For MS a "time is brain" concept would comprise an early initiation of first line therapy as well as sensitive and structured monitoring of disease activity under therapy in conjunction with a low threshold for timely treatment optimization to achieve sustained freedom from measurable disease activity. This approach may substantially improve the long-term outcome in patients who show insufficient response to platform therapies. The intersectorial collaboration in regional MS care networks involving office-based neurologists and specialized MS centers may facilitate the timely use of highly active therapies with...
Source: Der Nervenarzt - November 12, 2015 Category: Neurology Authors: Linker R, Kallmann BA, Kleinschnitz C, Rieckmann P, Mäurer M, Schwab S Tags: Nervenarzt Source Type: research

Polymorphism of brain derived neurotrophic factor and recovery of functions after ischemic stroke.
CONCLUSION: After ischemic stroke, motor functions and everyday activities improved continuously over a period of at least 6 months. The BDNF polymorphism did not influence this development. PMID: 26391958 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - September 23, 2015 Category: Neurology Authors: Liepert J, Heller A, Behnisch G, Schoenfeld A Tags: Nervenarzt Source Type: research