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Source: Journal of Neurosurgery

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Total 581 results found since Jan 2013.

Initial experience with transcarotid arterial revascularization with flow reversal in the management of symptomatic carotid stenosis
CONCLUSIONS: The authors' initial experience with TCAR suggests that it might provide an effective alternative to carotid endarterectomy and carotid artery stenting in the management of symptomatic carotid stenosis in patients with high-risk anatomical and medical characteristics.PMID:37029678 | DOI:10.3171/2023.2.JNS222377
Source: Journal of Neurosurgery - April 8, 2023 Category: Neurosurgery Authors: Joshua Feler Radmehr Torabi Krisztina Moldovan Jonathan Poggi Elias Shaaya Matthew Anderson Cameron Ayala Ankush Bajaj Silas Monje Curt Doberstein Source Type: research

Early reperfusion and clinical outcomes in patients with M2 occlusion: pooled analysis of the PROACT II, IMS, and IMS II studies.
Conclusions A positive correlation between successful early reperfusion and clinical outcome could not be demonstrated for patients with M2 occlusion. Irrespective of reperfusion status, such patients have better outcomes than those with more proximal occlusions, with more than 50% achieving functional independence at 3 months. PMID: 25259569 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - September 26, 2014 Category: Neurosurgery Authors: Rahme R, Yeatts SD, Abruzzo TA, Jimenez L, Fan L, Tomsick TA, Ringer AJ, Furlan AJ, Broderick JP, Khatri P Tags: J Neurosurg Source Type: research

Unstable moyamoya disease: clinical features and impact on perioperative ischemic complications.
CONCLUSIONS Unstable moyamoya disease, more prevalent in younger patients and those with underlying disease, is a possible risk factor for perioperative ischemic complications. Recognition of unstable moyamoya disease may contribute to an improved surgical result through focused perioperative management based on appropriate surgical risk stratification. PMID: 25423271 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 25, 2014 Category: Neurosurgery Authors: Funaki T, Takahashi JC, Takagi Y, Kikuchi T, Yoshida K, Mitsuhara T, Kataoka H, Okada T, Fushimi Y, Miyamoto S Tags: J Neurosurg Source Type: research

Restoration of ankle movements with the ActiGait implantable drop foot stimulator: a safe and reliable treatment option for permanent central leg palsy.
CONCLUSIONS The ActiGait implantable drop foot stimulator improves gait speed, endurance, and quality of life in patients with stroke-related drop foot. Regarding gait speed, the ActiGait system appears to be advantageous compared with foot orthosis or surface stimulation devices. Randomized trials with more patients and longer observation periods are needed to prove the long-term benefit of this device. PMID: 26207599 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 24, 2015 Category: Neurosurgery Authors: Martin KD, Polanski WH, Schulz AK, Jöbges M, Hoff H, Schackert G, Pinzer T, Sobottka SB Tags: J Neurosurg Source Type: research

CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
CONCLUSIONS This is the first study examining genetic variants and their effects in symptomatic ICAD. Variant alleles of CYP2C19 (*2, *3, *8) were associated with lower odds of the primary and secondary composite endpoints. However, the direction of the association was opposite of what is expected based on this SNP. This may reflect an incomplete understanding of this genetic variation and its effect in symptomatic ICAD and warrants further investigations. PMID: 26587656 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 20, 2015 Category: Neurosurgery Authors: Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA Tags: J Neurosurg Source Type: research

Safety and efficacy of the Pipeline embolization device for treatment of intracranial aneurysms: a pooled analysis of 3 large studies.
CONCLUSIONS Endovascular treatment of intracranial aneurysms with the PED is safe and effective. Angiographic occlusion rates progressed with follow-up. Rates of stroke, hemorrhage, morbidity and mortality, and retreatment were low, especially given the fact that the aneurysms treated were generally large and wide necked. PMID: 27791519 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 27, 2016 Category: Neurosurgery Authors: Kallmes DF, Brinjikji W, Cekirge S, Fiorella D, Hanel RA, Jabbour P, Lopes D, Lylyk P, McDougall CG, Siddiqui A Tags: J Neurosurg Source Type: research

Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats.
CONCLUSIONS Infused MSCs may inhibit endothelial dysfunction to suppress hemorrhagic events and facilitate functional outcome. Combined therapy of infused MSCs after rtPA therapy facilitated early behavioral recovery. PMID: 28059661 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2017 Category: Neurosurgery Authors: Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Namioka T, Namioka A, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O Tags: J Neurosurg Source Type: research

Performing concurrent operations in academic vascular neurosurgery does not affect patient outcomes.
CONCLUSIONS Overall, there was a significant difference in the types of concurrent versus nonconcurrent cases, with more routine/elective cases for less sick patients scheduled in an overlapping fashion. After adjusting for patient demographics, procedure type, and clinical indicators, concurrent cases had longer procedure times, but equivalent patient outcomes, as compared with nonconcurrent vascular neurosurgical procedures. PMID: 28106498 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 19, 2017 Category: Neurosurgery Authors: Zygourakis CC, Lee J, Barba J, Lobo E, Lawton MT Tags: J Neurosurg Source Type: research

Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat.
CONCLUSIONSInfused MSCs may provide neuroprotection to facilitate functional outcomes and reduce ischemic lesion volume as evaluated in a newly developed rat model of persistent BAO. PMID: 30485204 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Second-look strokectomy of cerebral infarction areas in patients with severe herniation.
CONCLUSIONSIn this study in comparison to former studies, mortality rates were lower and clinical outcome was comparable to that of previously published trials regarding large cerebral infarctions. Second surgery including strokectomy may help achieve better outcomes, especially in cases of infarction of more than one vascular territory. PMID: 30611135 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 4, 2019 Category: Neurosurgery Authors: Schwake M, Schipmann S, Müther M, Stögbauer L, Hanning U, Sporns PB, Ewelt C, Dziewas R, Minnerup J, Holling M, Stummer W Tags: J Neurosurg Source Type: research

Neutrophil-to-lymphocyte ratio as an independent predictor for unfavorable functional outcome in aneurysmal subarachnoid hemorrhage.
CONCLUSIONSAmong aSAH patients, NLR represents an independent parameter associated with unfavorable functional outcome. Whether the impact of NLR on functional outcome is related to preexisting comorbidities or represents independent causal relationships in the context of stroke-associated immunosuppression should be investigated in future studies. PMID: 30717052 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 1, 2019 Category: Neurosurgery Authors: Giede-Jeppe A, Reichl J, Sprügel MI, Lücking H, Hoelter P, Eyüpoglu IY, Kuramatsu JB, Huttner HB, Gerner ST Tags: J Neurosurg Source Type: research

Multimodal cerebral arteriovenous malformation treatment: a 12-year experience and comparison of key outcomes to ARUBA.
CONCLUSIONS: This multimodal approach to the selection and treatment of patients with brain AVMs yields good clinical outcomes with key safety endpoints (stroke, death, and mRS score 0-1) better than the ARUBA intervention arm and similar to the ARUBA medical arm at 5 years of follow-up. Results compare favorably to natural history cohorts at longer follow-up times. This suggests that tertiary care centers with integrated programs, expertise in patient selection, and individualized treatment approaches may allow for better clinical outcomes than reported in ARUBA. It supports current registry studies and merits considerati...
Source: Journal of Neurosurgery - October 31, 2019 Category: Neurosurgery Authors: Pulli B, Chapman PH, Ogilvy CS, Patel AB, Stapleton CJ, Leslie-Mazwi TM, Hirsch JA, Carter BS, Rabinov JD Tags: J Neurosurg Source Type: research

Comparison of robotic-assisted carotid stenting and manual carotid stenting through the transradial approach.
CONCLUSIONS: The authors' results suggest that RA TR CAS is feasible, safe, and effective. Neurovascular-specific engineering and software modifications are needed prior to complete remote control. Remote control has important implications regarding patient access to lifesaving procedures for conditions such as stroke and aneurysm rupture as well as operative precision. Future clinical investigations among larger cohorts are needed to demonstrate reliable performance and patient benefit. PMID: 32858520 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 27, 2020 Category: Neurosurgery Authors: Weinberg JH, Sweid A, Sajja K, Gooch MR, Herial N, Tjoumakaris S, Rosenwasser RH, Jabbour P Tags: J Neurosurg Source Type: research