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Quantitative T2'-Mapping in Acute Ischemic Stroke Clinical Sciences
Conclusions— Motion-corrected T2'-mapping reveals significant and gradually declining values from healthy to perfusion-disturbed to apparent diffusion coefficient-restricted tissue. Current T2'-mapping can differentiate between the ischemic core and the perfusion-impaired areas but not on its own between penumbral and oligemic tissue.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Bauer, S., Wagner, M., Seiler, A., Hattingen, E., Deichmann, R., Noth, U., Singer, O. C. Tags: Imaging, Acute Cerebral Infarction, Brain Circulation and Metabolism, Computerized tomography and Magnetic Resonance Imaging, Other imaging Clinical Sciences Source Type: research

Systemic Inflammation Impairs Tissue Reperfusion Through Endothelin-Dependent Mechanisms in Cerebral Ischemia Basic Sciences
Conclusions— These data suggest patients with a raised inflammatory profile may have persistent deficits in perfusion after reopening of an occluded vessel. Future therapeutic strategies to interrupt the mechanism identified could lead to enhanced recovery of penumbra in patients with a heightened inflammatory burden and a better outcome after stroke.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Murray, K. N., Girard, S., Holmes, W. M., Parkes, L. M., Williams, S. R., Parry-Jones, A. R., Allan, S. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Risk Factors for Stroke, Neuroprotectors Basic Sciences Source Type: research

Acute Blood Pressure Reduction in Patients With Intracerebral Hemorrhage Does Not Result in Borderzone Region Hypoperfusion Clinical Sciences
Conclusions— BP reduction does not increase the volume of critically hypoperfused borderzone or perihematoma tissue. These data support the safety of early BP reduction in intracerebral hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00963976.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Gould, B., McCourt, R., Gioia, L. C., Kate, M., Hill, M. D., Asdaghi, N., Dowlatshahi, D., Jeerakathil, T., Coutts, S. B., Demchuk, A. M., Emery, D., Shuaib, A., Butcher, K., on behalf of the ICH ADAPT Investigators Tags: Cerebrovascular disease/stroke, Other imaging, Intracerebral Hemorrhage Clinical Sciences Source Type: research

Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes Clinical Sciences
Conclusions— Poor correlation between infarct volume and time after stroke onset suggests that there are factors more powerful than time in determining infarct size within the first 30 hours. The observations suggest that highly variable cerebral perfusion via the collateral circulation may primarily determine infarct growth dynamics. If verified, clinical implications include the possibility of treating many patients outside traditional time windows.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Hakimelahi, R., Vachha, B. A., Copen, W. A., Papini, G. D. E., He, J., Higazi, M. M., Lev, M. H., Schaefer, P. W., Yoo, A. J., Schwamm, L. H., Gonzalez, R. G. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI: A New Target for Fibrinolysis? Brief Reports
Conclusions— SAH and acute ischemic stroke significantly impair the glymphatic system perfusion. In these contexts, injection of tissue-type plasminogen activator either intracerebroventricularly to clear perivascular spaces (for SAH) or intravenously to restore arterial patency (for ischemic stroke) may improve glymphatic function.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Gaberel, T., Gakuba, C., Goulay, R., De Lizarrondo, S. M., Hanouz, J.-L., Emery, E., Touze, E., Vivien, D., Gauberti, M. Tags: Animal models of human disease, Fibrinolysis, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Computed Tomographic Angiography and Cerebral Blood Volume Can Predict Final Infarct Volume and Outcome After Recanalization Clinical Sciences
Conclusions— CTASI and CBV were better at predicting 24-hour infarct and outcome than NECT. Appropriate advanced imaged guided selection may improve outcomes in large-vessel stroke treated with the newest techniques.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Lum, C., Ahmed, M. E., Patro, S., Thornhill, R., Hogan, M., Iancu, D., Lesiuk, H., dos Santos, M., Dowlatshahi, D., on behalf of the Ottawa Stroke Research Group (OSRG) Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Angioplasty and Stenting Clinical Sciences Source Type: research

Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles Basic Sciences
Conclusions— The increased vasoconstriction of PAs during early postischemic reperfusion seems to be due to calcium sensitization of smooth muscle and could contribute to infarct expansion and limit neuroprotective agents from reaching their target tissue.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Cipolla, M. J., Chan, S.-L., Sweet, J., Tavares, M. J., Gokina, N., Brayden, J. E. Tags: Animal models of human disease, Acute Cerebral Infarction, Brain Circulation and Metabolism, Other Vascular biology Basic Sciences Source Type: research

Six-Minute Magnetic Resonance Imaging Protocol for Evaluation of Acute Ischemic Stroke: Pushing the Boundaries Clinical Sciences
Conclusions— A 6-minute multimodal MR protocol with good diagnostic quality is feasible for the evaluation of patients with acute ischemic stroke and can result in significant reduction in scan time rivaling that of the multimodal computed tomographic protocol.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., Drake, K., Coull, B. M., Kidwell, C. S. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Unexplained Early Neurological Deterioration After Intravenous Thrombolysis: Incidence, Predictors, and Associated Factors Clinical Sciences
Conclusions— ENDunexplained affected 7% of patients and accounted for most cases of END. Several predictors and associated factors were identified, with important implications regarding underlying mechanisms and potential prevention of this ominous event.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Seners, P., Turc, G., Tisserand, M., Legrand, L., Labeyrie, M.-A., Calvet, D., Meder, J.-F., Mas, J.-L., Oppenheim, C., Baron, J.-C. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Pretreatment Blood-Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator Clinical Sciences
Conclusions— A perfusion-weighted imaging–derived index of blood–brain barrier damage measured before intravenous tissue-type plasminogen activator is given is associated with the severity of ICH after treatment in patients with acute ischemic stroke.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Leigh, R., Jen, S. S., Hillis, A. E., Krakauer, J. W., Barker, P. B., on behalf of the STIR and VISTA Imaging Investigators, Albers, Davis, Donnan, Fisher, Furlan, Grotta, Hacke, Kang, Kidwell, Koroshetz, Lees, Lev, Liebeskind, Sorensen, Thijs, Thomalla, Tags: CT and MRI, Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis, Other Vascular biology Clinical Sciences Source Type: research

Comparison of Computed Tomographic and Magnetic Resonance Perfusion Measurements in Acute Ischemic Stroke: Back-to-Back Quantitative Analysis Clinical Sciences
Conclusions— MRP and CTP can be used interchangeably if one uses Tmax measurement.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Lin, L., Bivard, A., Levi, C. R., Parsons, M. W. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation Clinical Sciences
Conclusions— A lower HOB angle results in an increase in cortical CBF without a significant change in arterial flow velocity in AIS, but there is variability across patients in this response. Bedside CBF monitoring with diffuse correlation spectroscopy provides a potential means to individualize interventions designed to optimize CBF in AIS.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Favilla, C. G., Mesquita, R. C., Mullen, M., Durduran, T., Lu, X., Kim, M. N., Minkoff, D. L., Kasner, S. E., Greenberg, J. H., Yodh, A. G., Detre, J. A. Tags: Brain Circulation and Metabolism, Doppler ultrasound, Transcranial Doppler etc. Clinical Sciences Source Type: research

Cerebral Perfusion and Blood Pressure Do Not Affect Perihematoma Edema Growth in Acute Intracerebral Hemorrhage Clinical Sciences
Conclusions— Lower perihematoma CBF and BP treatment do not exacerbate edema growth. These data do not support a cytotoxic edema pathogenesis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00963976.
Source: Stroke - April 28, 2014 Category: Neurology Authors: McCourt, R., Gould, B., Gioia, L., Kate, M., Coutts, S. B., Dowlatshahi, D., Asdaghi, N., Jeerakathil, T., Hill, M. D., Demchuk, A. M., Buck, B., Emery, D., Butcher, K., on behalf of the ICH ADAPT Investigators Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Optimal Perfusion Computed Tomographic Thresholds for Ischemic Core and Penumbra Are Not Time Dependent in the Clinically Relevant Time Window Clinical Sciences
Conclusions— Time does not influence the optimal PCT thresholds to delineate the ischemic core and penumbra in the first 15 hours after symptom onset for relative mean transit time and relative cerebral blood volume, the optimal parameters to delineate ischemic core and penumbra.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Qiao, Y., Zhu, G., Patrie, J., Xin, W., Michel, P., Eskandari, A., Jovin, T., Wintermark, M. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Vertebral Artery Hypoplasia: Frequency and Effect on Cerebellar Blood Flow Characteristics Clinical Sciences
Conclusions— VAH is a frequent vascular variant that can lead to a relative regional hypoperfusion in the PICA territory. Additional research should clarify the pathophysiological role of VAH in PCI.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Thierfelder, K. M., Baumann, A. B., Sommer, W. H., Armbruster, M., Opherk, C., Janssen, H., Reiser, M. F., Straube, A., von Baumgarten, L. Tags: Brain Circulation and Metabolism, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

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