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Source: Trends in Parasitology
Vaccination: Malaria Vaccine
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Total 45 results found since Jan 2013.
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Trends Parasitol. 2023 Jul 21:S1471-4922(23)00147-2. doi: 10.1016/j.pt.2023.06.011. Online ahead of print.ABSTRACTMalaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developi...
Source: Trends in Parasitology - July 22, 2023 Category: Parasitology Authors: Thayne H Dickey Niraj H Tolia Source Type: research
Housebreaking Plasmodium parasites leave their fingerprints at the door
Trends Parasitol. 2022 Sep 23:S1471-4922(22)00209-4. doi: 10.1016/j.pt.2022.09.005. Online ahead of print.ABSTRACTProtective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design.PMID:36163104 | DOI:10.1016/j.pt.2022.09.005
Source: Trends in Parasitology - September 26, 2022 Category: Parasitology Authors: Lara Bardtke Ian A Cockburn Source Type: research
Deceiving and escaping complement - the evasive journey of the malaria parasite
Trends Parasitol. 2022 Sep 8:S1471-4922(22)00190-8. doi: 10.1016/j.pt.2022.08.013. Online ahead of print.ABSTRACTDuring its life cycle, Plasmodium, the malaria parasite, is exposed to the human and mosquito complement systems. Early experiments demonstrated that activation of complement can pose a serious threat to parasites, but recent studies revealed complement-evasion mechanisms important for parasite survival. Blood-stage parasites and gametes recruit regulators to neutralize human complement activation, while ookinetes inhibit mosquito complement by disrupting epithelial nitration in response to midgut invasion. Here...
Source: Trends in Parasitology - September 11, 2022 Category: Parasitology Authors: Maartje R Inklaar Carolina Barillas-Mury Matthijs M Jore Source Type: research
