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Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway
This study aimed to investigate the protective effects of SIL against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, and the mechanisms involved. Firstly, the toxicity of SIL was evaluated, and safe concentrations were chosen for subsequent experiments. Then, SIL exerts significant neuroprotection against hypoxia/reoxygenation (HR) injury in N2a cells, as manifested by increased cell viability, decreased apoptotic rate, LDH, and ROS generation. Additionally, SIL was found to inhibit HR-induced apoptosis, mitochondria dysfunction, and oxidative stress. However, silencing of GAS6 inhibited the neuroprotecti...
Source: Toxicology - August 6, 2023 Category: Toxicology Authors: Weiping Li Zhe Zhang Jiawen Li Jun Mu Meng Sun Xue Wu Xiaochen Niu Yang Yang Huanle Yan Xiaoling Xu Chengxu Xue Lu Qian Ye Tian Source Type: research

Effect Of Persistent Organic Pollutants In Patients With Ischemic Stroke And All Stroke: A Systematic Review And Meta-Analysis
Toxicology. 2023 May 31:153567. doi: 10.1016/j.tox.2023.153567. Online ahead of print.ABSTRACTThe role of environmental contaminants and their association with stroke is still being determined. Association has been shown with air pollution, noise, and water pollution; however, the results are inconsistent across studies. A systematic review and meta-analysis of the effect of persistent organic pollutants (POP) in ischemic stroke patients were conducted; a comprehensive literature search was carried out until 30th June 2021 from different databases. The quality of all the articles which met our inclusion criteria was assess...
Source: Toxicology - June 2, 2023 Category: Toxicology Authors: Priya Dev Kamalesh Chakravarty Manoj Pandey Rakesh Ranjan Mareena Cyriac Vijaya Nath Mishra Abhishek Pathak Source Type: research

A Decade of e-Cigarettes: Limited Research & Unresolved Safety Concerns.
A Decade of e-Cigarettes: Limited Research & Unresolved Safety Concerns. Toxicology. 2016 Jul 28; Authors: Kaisar MA, Prasad S, Liles T, Cucullo L Abstract It is well known that tobacco consumption is a leading cause of preventable deaths worldwide and has been linked to major diseases ranging from cancer to chronic obstructive pulmonary disease, atherosclerosis, stroke and a host of neurological/neurodegenerative disorders. In the past decade a number of alternative vaping products have hit the market, rapidly gaining consumers especially among the younger population. Electronic nicotine delivery...
Source: Toxicology - July 27, 2016 Category: Toxicology Authors: Kaisar MA, Prasad S, Liles T, Cucullo L Tags: Toxicology Source Type: research

Cardiovascular responses to lead are biphasic, while methylmercury, but not inorganic mercury, monotonically increases blood pressure in rats.
Abstract Cardiovascular diseases, such as heart attack and stroke, are the major cause of death worldwide. It is well known that a high number of environmental and physiological risk factors contribute to the development of cardiovascular diseases. Although risk factors are additive, increased blood pressure (hypertension) is the greatest risk factor. Over the last two decades, a growing number of epidemiological studies associate environmental exposure to lead or mercury species with hypertension. However, cardiovascular effects beyond blood pressure are rarely studied and thresholds for effect not yet clear. To ...
Source: Toxicology - December 2, 2014 Category: Toxicology Authors: Wildemann TM, Mirhosseini N, Siciliano SD, Weber LP Tags: Toxicology Source Type: research