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Source: International Immunopharmacology

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Total 109 results found since Jan 2013.

Interleukin-33 improves the neurogenesis of neural stem cells in perinatal brain after hypoxia-ischemia
Int Immunopharmacol. 2023 Aug 11;123:110778. doi: 10.1016/j.intimp.2023.110778. Online ahead of print.ABSTRACTPerinatal hypoxia-ischemia (HI) insult is an important cause of neonatal encephalopathy, and the effective therapeutic approaches are currently limited. Interleukin (IL)-33 acts as a member of the IL-1 superfamily and has been shown to be neuroprotective following experimental neonatal HI and adult stroke. Here, we explore the effect of IL-33 and its specific receptor ST2 axis on endogenous neurogenesis in neonatal brain after HI. ST2 was found on the surface of NSCs, and the expression of ST2 was further enhanced ...
Source: International Immunopharmacology - August 13, 2023 Category: Allergy & Immunology Authors: Jing Tian Jieqiong Zhu Qiuxiang Fan Xiaotian Luo Qianying Nie Jingwei Yu Xiaoyong Wu Yanli Tang Tao Liu Hui Yin Source Type: research

Revisiting the role of the complement system in intracerebral hemorrhage and therapeutic prospects
Int Immunopharmacol. 2023 Aug 6;123:110744. doi: 10.1016/j.intimp.2023.110744. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. Despite its lower incidence than ischemic stroke, ICH remains a significant contributor to stroke-related mortality, and most survivors experience poor outcomes that significantly impact their quality of life. ICH has been accompanied by various complex pathological damage, including mechanical damage of brain tissue, hematoma mass effect, and th...
Source: International Immunopharmacology - August 8, 2023 Category: Allergy & Immunology Authors: Yuanyuan Li Chenxi Tao Na An Haoqi Liu Zhenhong Liu Hongrui Zhang Yikun Sun Yanwei Xing Yonghong Gao Source Type: research

Neuroinflammation and peripheral immunity: Focus on ischemic stroke
Int Immunopharmacol. 2023 May 28;120:110332. doi: 10.1016/j.intimp.2023.110332. Online ahead of print.ABSTRACTIschemic stroke (IS) produces a powerful inflammatory cascade in the brain, resulting in the occurrence of neuroinflammation. Neuroinflammation is triggered not only by resident immune cells, but also by neutrophils, macrophages, and T lymphocytes infiltrating the peripheral immune system. The disruption of the blood-brain barrier appears to exacerbate inflammatory infiltrates after IS. In turn, IS also has effects on peripheral immunity, manifested as peripheral immunosuppression syndrome, which increases the risk...
Source: International Immunopharmacology - May 30, 2023 Category: Allergy & Immunology Authors: Huiqing Wang Shenyang Zhang Lili Xie Zhe Zhong Fuling Yan Source Type: research

BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion
Int Immunopharmacol. 2023 May 10;119:110201. doi: 10.1016/j.intimp.2023.110201. Online ahead of print.ABSTRACTBRG1 is a key factor in the process of apoptosis and oxidative damage; however, its role in the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle cerebral artery occlusion (MCAO) reperfusion in mice, microglia were significantly activated in the cerebral cortex of the infarct area, and BRG1 expression was increased in the mouse MCAO/R model, peaking at 4 days. In microglia subjected to OGD/R, BRG1 expression increased and peaked at 12 h after reoxygenation. After ischemic stroke,...
Source: International Immunopharmacology - May 12, 2023 Category: Allergy & Immunology Authors: Kongwei Guo Yanxing Shang Zhao Wang Yu Li Jinliang Chen Baofeng Zhu Dongmei Zhang Jianrong Chen Source Type: research

Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF- κB/NLRP3 signaling pathway
In this study, lipopolysaccharide (LPS) was used to establish an inflammation model, and the therapeutic effect of TP-5 was evaluated. Behavioral tests showed that TP-5 treatment could improve the performance of LPS-treated mice in the open field and pole test, but not hanging wire test. TP-5 also attenuated neuronal lesions in the brains of LPS-treated mice. TP-5 reduced cytotoxicity and morphological changes in activated microglia. Label-free quantitative analysis indicated that the expression of multiple proteins and the activation of associated signaling pathways were altered by TP-5. Moreover, TP-5 could inhibit LPS-i...
Source: International Immunopharmacology - April 30, 2023 Category: Allergy & Immunology Authors: Si-Jia Peng Ya Feng Xuan Li Xi-Xi Wang Yu Wang Bu-Tian Zhou Ye Liu Te Liu Yun-Cheng Wu Source Type: research

Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation
In this study, we reviewed the role of the gut microbiome in cerebral stroke and the underlying mechanism of the AMPK signaling pathway in stroke. AMPK mediators in nerve repair and the regulation of intestinal microbial balance were also summarized.PMID:37031605 | DOI:10.1016/j.intimp.2023.110126
Source: International Immunopharmacology - April 9, 2023 Category: Allergy & Immunology Authors: Airu Huang Ling Ji Yamei Li Yufeng Li Qian Yu Source Type: research

Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway
Int Immunopharmacol. 2023 Apr;117:109980. doi: 10.1016/j.intimp.2023.109980. Epub 2023 Mar 8.ABSTRACTDual-specificity phosphatase 26 (DUSP26) is linked to a broad range of human disorders as it affects numerous signaling cascades. However, the involvement of DUSP26 in ischemic stroke has not been explored. Here, we investigated DUSP26 as a key mediator of oxygen-glucose deprivation/reoxygenation (OGD/R)-associated neuronal injury, an in vitro model for investigating ischemic stroke. A decline in DUSP26 occurred in neurons suffering from OGD/R. A deficiency in DUSP26 rendered neurons more susceptible to OGD/R by aggravating...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Hongxia Zhao Jianrui Lv Lihua Meng Junlin Lv Zhe Li Source Type: research

Role of IL-17A in different stages of ischemic stroke
Int Immunopharmacol. 2023 Apr;117:109926. doi: 10.1016/j.intimp.2023.109926. Epub 2023 Mar 11.ABSTRACTInterleukin-17A (IL-17A) plays an important role in the progression of ischemic stroke. IL-17A mediates the endothelial inflammatory response, promotes water and sodium retention, and changes the electrophysiological structure of the atrium, accelerating the progression of ischemic stroke risk factors such as atherosclerotic plaques, hypertension, and atrial fibrillation. In the acute phase of ischemic stroke, IL-17A mediates neuronal injury through neutrophil chemotaxis to the site of injury, the induction of neuronal apo...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Xiuping Chen Yi Zhang Qian Ding Yanru He Hui Li Source Type: research

Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway
CONCLUSION: BBR-exos can carry miR-182-5p to injured neurons and inhibit the expression of Rac1, which could inhibit neuroinflammation and improved brain injury after ischemic stroke.PMID:36996739 | DOI:10.1016/j.intimp.2023.110047
Source: International Immunopharmacology - March 30, 2023 Category: Allergy & Immunology Authors: Wangli Ding Qiuchen Gu Manman Liu Junqing Zou Jianguo Sun Junrong Zhu Source Type: research