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Source: Behavioural Brain Research
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Total 143 results found since Jan 2013.
Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia.
CONCLUSION: These findings could help clinicians to optimize antipsychotic treatment in patients with schizophrenia by balancing risks and benefits in clinical practice. However, further investigations with larger sample sizes and more robust study designs that focus on each antipsychotic agent are needed.
PMID: 33417992 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - January 5, 2021 Category: Neurology Authors: Yoshida K, Takeuchi H Tags: Behav Brain Res Source Type: research
Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect.
In this study, a mouse model of unilateral spatial neglect was created to investigate whether the size of the lesion is related to the severity of ipsilesional spatial bias and the recovery process. Focal infarction was induced in the right medial agranular cortex (AGm) of mice via photothrombosis. After induction of cerebral infarction, ipsilesional spatial bias was evaluated for 9 consecutive days. The major findings were as follows: (1) unilateral local infarction of the AGm resulted in ipsilateral bias during internally guided decision-making; (2) the lesion size was correlated with the degree of impairment rather than...
Source: Behavioural Brain Research - December 29, 2020 Category: Neurology Authors: Ishii D, Osaki H, Yozu A, Ishibashi K, Kawamura K, Yamamoto S, Miyata M, Kohno Y Tags: Behav Brain Res Source Type: research
Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats.
Abstract
Rehabilitation training is routine for children who experience stroke, but its protective mechanism remains unclear. To study the effect of treadmill training intensity on hippocampal synaptic plasticity after cerebral ischemia, a model of middle cerebral artery occlusion (MCAO)/reperfusion was established in young rats to simulate childhood ischemic stroke. The rats were randomly allocated into five groups: sham operation, MCAO, low-intensity exercise and MCAO (5 m/min), medium-intensity exercise and MCAO (10 m/min), and high-intensity exercise and MCAO (15 m/min). Intervention was continued for 14...
Source: Behavioural Brain Research - December 21, 2020 Category: Neurology Authors: Pan G, Cheng J, Shen W, Lin Y, Zhu A, Jin L, Xie Q, Zhu M, Liu C, Tu F, Chen X Tags: Behav Brain Res Source Type: research
Spinal or Cortical direct current stimulation: Which is the best? Evidence from apraxia of speech in post-stroke aphasia.
Abstract
To date, new advances in technology have already shown the effectiveness of non-invasive brain stimulation and, in particular, of transcranial direct current stimulation (tDCS), in enhancing language recovery in post-stroke aphasia. More recently, it has been suggested that the stimulation over the spinal cord improves the production of words associated to sensorimotor schemata, such as action verbs. Here, for the first time, we present evidence that transpinal direct current stimulation (tsDCS) combined with a language training is efficacious for the recovery from speech apraxia, a motor speech disorder ...
Source: Behavioural Brain Research - November 15, 2020 Category: Neurology Authors: Pisano F, Caltagirone C, Incoccia C, Marangolo P Tags: Behav Brain Res Source Type: research
Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats.
Abstract
Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvements that can be driven by rehabilitative training of the paretic forelimb. The influence of learning new ways of skillfully using the two hands together on paretic side function is much less clear. To begin to explore this, we developed a new cooperative bimanual skilled reaching task for rats,...
Source: Behavioural Brain Research - September 13, 2020 Category: Neurology Authors: Dutcher AM, Truong KV, Miller DD, Allred RP, Nudi E, Jones TA Tags: Behav Brain Res Source Type: research
H2S prevents injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.
Abstract
Cerebral ischemia/reperfusion (I/R) injury is a leading cause of learning and memory dysfunction. Hydrogen sulfide (H2S) has been shown to confer neuroprotection in various neurodegenerative diseases, including cerebral I/R-induced hippocampal CA1 injury. However, the underlying mechanisms have not been completely understood. In the present study, rats were pretreated with SAM/NaHS (SAM, an H2S agonist, and NaHS, an H2S donor) only or SAM/NaHS combined with CaM (an activator of CaMKII) prior to cerebral ischemia. The Morris water maze test demonstrated that SAM/NaHS could alleviate learning and memory imp...
Source: Behavioural Brain Research - January 28, 2020 Category: Neurology Authors: Song YJ, Shi Y, Cui M, Li M, Wen XR, Zhou XY, Lou HQ, Wang YL, Qi DS, Tang M, Zhang XB Tags: Behav Brain Res Source Type: research
Motor deficit in the mouse ferric chloride-induced distal middle cerebral artery occlusion model of stroke.
In this study, we reproduced the recently developed model and expanded its characterization by thorough evaluation of blood supply, cerebral infarction, and motor function in adult male and female mice up to 14 days after stroke. Our observations indicate near complete interruption of blood flow in the distal MCA shortly after application of 20% ferric chloride over the artery through a cranial window, which remained occluded for at least 4 hours. As expected, infarction of the brain tissue, documented by TTC and hematoxylin stains, was restricted to the cerebral cortex. We also systematically evaluated motor impairment ...
Source: Behavioural Brain Research - December 4, 2019 Category: Neurology Authors: Syeara N, Alamri FF, Jayaraman S, Lee P, Karamyan ST, Arumugam TV, Karamyan VT Tags: Behav Brain Res Source Type: research
GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury.
This study established a CI / R injury model in vivo and in vitro. The results showed that the expression of GAS5 was increased in CI / R rats, while miR-26b-5p expression was decreased. Besides, knockdown of GAS5 by siRNA (si-GAS5) reversed CI / R-induced apoptosis and inflammatory responses. Notably, bioinformatics analysis indicated that GAS5 competitively adsorbed miR-26b-5p, and the relationship was further confirmed by pull-down assay. In addition, miR-26b-5p overexpression reversed CI / R-induced apoptosis and inflammatory responses, whereas low expression of miR-26b-5p had the opposite effect. Moreover, TargetScan ...
Source: Behavioural Brain Research - November 17, 2019 Category: Neurology Authors: Shangguan Y, Han J, Su H Tags: Behav Brain Res Source Type: research
Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke.
Abstract
Stroke leads to devastating outcomes including impairments of sensorimotor and cognitive function that may be long lasting. New intervention strategies are needed to overcome the long-lasting effects of ischemic injury. Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred chemical preconditioning and neuroprotection against stroke. The purpose of the current study was to determine whether the preconditioning can lead to functional improvements after stroke (done by transient middle cerebral artery occlusion). After 4 weeks of MICA feeding, half the rats underw...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Sumien N, Huang R, Chen Z, Vann PH, Wong JM, Li W, Yang S, Forster M, Yan LJ Tags: Behav Brain Res Source Type: research
Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats.
Abstract
Post-stroke depression (PSD) and post-stroke anxiety (PSA) are usually undertreated and many cases may remain undiagnosed, indicating a need for a better understanding of the underlying mechanisms. Current animal models of PSD and PSA using the middle cerebral artery occlusion model may be associated with motor deficits that can interfere with behavioral tests of depression- and anxiety-like behavior. Unilateral lesions of the medial prefrontal cortex (mPFC) have been reported to induce a depression- and anxiety-like phenotype in mice. The aim of this study was to examine the effects of unilateral microin...
Source: Behavioural Brain Research - September 11, 2019 Category: Neurology Authors: Happ DF, Wegener G, Tasker RA Tags: Behav Brain Res Source Type: research
Functions of subventricular zone neural precursor cells in stroke recovery.
Abstract
The proliferation and ectopic migration of neural precursor cells (NPCs) in response to ischemic brain injury was first reported two decades ago. Since then, studies of brain injury-induced subventricular zone cytogenesis, primarily in rodent models, have provided insight into the cellular and molecular determinants of this phenomenon and its modulation by various factors. However, despite considerable correlational evidence-and some direct evidence-to support contributions of NPCs to behavioral recovery after stroke, the causal mechanisms have not been identified. Here we discuss the subventricular zone ...
Source: Behavioural Brain Research - September 3, 2019 Category: Neurology Authors: Williamson MR, Jones TA, Drew MR Tags: Behav Brain Res Source Type: research
Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.
Abstract
Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors. The ROCKs heavily influence neuronal architecture and structural plasticity, and ROCKs are putative drug targets for various brain disorders. While the pan-ROCK inhibitor Fasudil has been clinically approved to treat hypertension, heart failure, glaucoma, spinal cord injury, and stroke, a barrier to progress on this therapeutic avenue is the lack of experimental comparisons between pharmacologic and genetic manipulation of ROCKs. Our study begins to a...
Source: Behavioural Brain Research - July 10, 2019 Category: Neurology Authors: Greathouse KM, Henderson BW, Gentry EG, Herskowitz JH Tags: Behav Brain Res Source Type: research
The neuroanatomy of age perception.
Abstract
The concept of age is a fundamental aspect of mental life. However, it is not clear whether age is more an autobiographical detail we remember, a number indicating the years we live, or an inherent part of our subjective self-perception. An insight may be inferred from the underlying neuroanatomy. To investigate the neuroanatomy of age perception, we used lesion analysis in 7 patients with age-disorientation due to acute stroke, as compared to a control group of 9 age-oriented patients. Age-disoriented patients underestimated their age by 17.8±5.0 years. Lesion analysis indicated main regions of overlap ...
Source: Behavioural Brain Research - June 19, 2019 Category: Neurology Authors: Naveh T, Arzy S Tags: Behav Brain Res Source Type: research
Insult-induced aberrant hippocampal neurogenesis: functional consequences and possible therapeutic strategies.
Abstract
Adult hippocampal neurogenesis plays a critical role in a wide spectrum of hippocampus-dependent functions. Brain pathologies that involve the hippocampus like epilepsy, stroke, and traumatic brain injury, are commonly associated with cognitive impairments and mood disorders. These insults can affect the neural stem cells and the subsequent neurogenic cascade in the hippocampus, resulting in the induction of aberrant neurogenesis, which is thought to compromise hippocampal network function, thereby hampering hippocampus-dependent behavior. We here summarize recent preclinical literature on hippocampal ins...
Source: Behavioural Brain Research - June 10, 2019 Category: Neurology Authors: Bielefeld P, Durá I, Danielewicz J, Lucassen PJ, Baekelandt V, Abrous DN, Encinas JM, Fitzsimons CP Tags: Behav Brain Res Source Type: research
Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus.
Abstract
Existing evidence from clinical and animal experiments all indicated that fluoxetine, selective serotonin-reuptake inhibitor (SSRI) and anti-depressant drug, has neuroprotection and improve functional outcomes after stroke. Endoplasmic reticulum stress (ERS) inducing apoptosis after cerebral ischemia reperfusion injury was demonstrated in our previous. This trial was examined whether fluoxetine mitigates ERS-induced neuron apoptosis. Male sprague-dawley rats of cerebral ischemia reperfusion injury was produced via middle cerebral artery occlusion (MCAO) strategy, with ischemia for 90 min and reperfusion...
Source: Behavioural Brain Research - May 15, 2019 Category: Neurology Authors: Xu F, Zhang G, Yin J, Zhang Q, Ge MY, Peng L, Wang S, Li Y Tags: Behav Brain Res Source Type: research
