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Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Conclusions: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. © 2017 International Parkinson and Movement Disorder Society
Source: Movement Disorders - April 1, 2017 Category: Neurology Authors: G ünter U. Höglinger, Gesine Respondek, Maria Stamelou, Carolin Kurz, Keith A. Josephs, Anthony E. Lang, Brit Mollenhauer, Ulrich Müller, Christer Nilsson, Jennifer L. Whitwell, Thomas Arzberger, Elisabet Englund, Ellen Gelpi, Armin Giese, David J. Irw Tags: Research Article Source Type: research

Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease
ConclusionVascular comorbidity is significantly associated with cognitive and gait impairment in patients with early PD, which may have prognostic and treatment implications. © 2016 International Parkinson and Movement Disorder Society
Source: Movement Disorders - June 20, 2016 Category: Neurology Authors: Naveed Malek, Michael A. Lawton, Diane M. A. Swallow, Katherine A. Grosset, Sarah L. Marrinan, Nin Bajaj, Roger A. Barker, David J. Burn, John Hardy, Huw R. Morris, Nigel M. Williams, Nicholas Wood, Yoav Ben‐Shlomo, Donald G. Grosset, Tags: Research Article Source Type: research

The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort
ConclusionOur cohort provides a valuable resource for biomarker discovery and validation in PD. Clinical data and biospecimens, available through The Michael J. Fox Foundation for Parkinson's Research and the National Institute of Neurological Disorders and Stroke, can serve as a platform for discovering biomarkers in clinically typical PD and comparisons across PD's broad and heterogeneous spectrum. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
Source: Movement Disorders - March 31, 2016 Category: Neurology Authors: Un Jung Kang, Jennifer G. Goldman, Roy N. Alcalay, Tao Xie, Paul Tuite, Claire Henchcliffe, Penelope Hogarth, Amy W. Amara, Samuel Frank, Alice Rudolph, Cynthia Casaceli, Howard Andrews, Katrina Gwinn, Margaret Sutherland, Catherine Kopil, Lona Vincent, M Tags: Research Article Source Type: research

The NINDS Parkinson's disease biomarkers program
ConclusionsBy making samples and data widely available, using stringent operating procedures based on existing standards, hypothesis testing for biomarker discovery, and providing a resource that complements existing programs, the Parkinson's Disease Biomarker Program will accelerate the pace of PD biomarker research. © 2015 International Parkinson and Movement Disorder Society
Source: Movement Disorders - October 7, 2015 Category: Neurology Authors: Liana S. Rosenthal, Daniel Drake, Roy N. Alcalay, Debra Babcock, F. DuBois Bowman, Alice Chen‐Plotkin, Ted M. Dawson, Richard B. Dewey, Dwight C. German, Xuemei Huang, Barry Landin, Matthew McAuliffe, Vladislav A. Petyuk, Clemens R. Scherzer, Coryse St. Tags: Research Article Source Type: research

Region‐Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy
ConclusionThese results demonstrate widespread alterations of matrix metalloproteinase expression in MSA and a pattern of increased matrix metalloproteinase‐2 expression and activity affecting preferentially a brain region severely affected (putamen) over a relatively spared region (frontal cortex). Elevated matrix metalloproteinase expression may thus contribute to the disease process in MSA by promoting blood–brain barrier dysfunction and/or myelin degradation. © 2015 International Parkinson and Movement Disorder Society
Source: Movement Disorders - August 1, 2015 Category: Neurology Authors: Fares Bassil, Arnaud Monvoisin, Marie‐Helene Canron, Anne Vital, Wassilios G. Meissner, François Tison, Pierre‐Olivier Fernagut Tags: Research Article Source Type: research

Post‐ischemic stroke Holmes' tremor of the upper limb
Source: Movement Disorders - August 7, 2013 Category: Neurology Authors: Stefan Kipfer, Susanna B. Frigerio Tags: Medical Images Source Type: research

Acute complications of movement disorders surgery: Effects of age and comorbidities
ABSTRACT The most common indication for movement disorder surgery is Parkinson's disease (PD), and the incidence of PD increases with age. The analysis reported here was undertaken with the primary goal of examining whether there is a relationship between peri‐operative complications and age. The Nationwide Inpatient Sample (Agency for Healthcare Research and Quality, Rockville, MD, USA) was queried for 10 years beginning in 1999 for patients undergoing deep brain stimulator insertion, pallidotomy, and thalamotomy for treatment of PD, essential tremor, and dystonia. Inpatient complications, including death, stroke (both ...
Source: Movement Disorders - July 16, 2013 Category: Neurology Authors: Anand I. Rughani, Mojgan Hodaie, Andres M. Lozano Tags: Research Article Source Type: research

Cardiovascular and mortality risks in Parkinson's disease patients treated with entacapone
ABSTRACT The controlled trial Stalevo Reduction in Dyskinesia Evaluation in Parkinson's Disease (STRIDE‐PD) reported an unexpected increase in acute myocardial infarction (AMI) with entacapone use in patients with Parkinson's disease (PD). The authors investigated whether entacapone increased cardiovascular and mortality risk compared with the use of a non‐levodopa dopamine agonist (DA) or a selective monoamine oxidase type‐B inhibitor (MAOBI). Using national Medicare data, a new‐user cohort of elderly patients with PD treated with entacapone was propensity score (PS) matched with new users of either DA or MAOBI. T...
Source: Movement Disorders - February 26, 2013 Category: Neurology Authors: David J. Graham, James R. Williams, Ya‐Hui Hsueh, Katlyn Calia, Mark Levenson, Simone P. Pinheiro, Thomas E. MaCurdy, David Shih, Chris Worrall, Jeffrey A. Kelman Tags: Research Article Source Type: research

Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and Neuroprotection and Natural History in Parkinson Plus Syndromes Criteria for the Diagnosis of Progressive Supranuclear Palsy
ABSTRACT Autopsy is the diagnostic gold standard for progressive supranuclear palsy (PSP). The National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy (NINDS‐SPSP) criteria for the clinical diagnosis of “probable” PSP are thought to possess high specificity and low sensitivity. The NINDS‐SPSP criteria for “possible” PSP are considered to increase sensitivity at the expense of specificity. The Neuroprotection and Natural History in Parkinson Plus Syndromes (NNIPPS) criteria are intended to improve sensitivity while maintaining high specificity. The aim of this study...
Source: Movement Disorders - January 1, 2013 Category: Neurology Authors: Gesine Respondek, Sigrun Roeber, Hans Kretzschmar, Claire Troakes, Safa Al‐Sarraj, Ellen Gelpi, Carles Gaig, Wang Zheng Chiu, John C. Swieten, Wolfgang H. Oertel, Günter U. Höglinger Tags: Research Article Source Type: research