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Angiogenesis after ischemic stroke
Acta Pharmacol Sin. 2023 Feb 24. doi: 10.1038/s41401-023-01061-2. Online ahead of print.ABSTRACTOwing to its high disability and mortality rates, stroke has been the second leading cause of death worldwide. Since the pathological mechanisms of stroke are not fully understood, there are few clinical treatment strategies available with an exception of tissue plasminogen activator (tPA), the only FDA-approved drug for the treatment of ischemic stroke. Angiogenesis is an important protective mechanism that promotes neural regeneration and functional recovery during the pathophysiological process of stroke. Thus, inducing angio...
Source: Acta Pharmacologica Sinica - February 24, 2023 Category: Drugs & Pharmacology Authors: Jie Fang Zhi Wang Chao-Yu Miao Source Type: research

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
In this study we investigated whether Ori exerted a protective effect against reperfusion injury-induced neuronal loss and the underlying mechanisms. Mice were subjected to transient middle cerebral artery occlusion (tMCAO), and were injected with Ori (5, 10, 20 mg/kg, i.p.) at the beginning of reperfusion. We showed that Ori treatment rescued neuronal loss in a dose-dependent manner by specifically inhibiting caspase-9-mediated neuronal apoptosis and exerted neuroprotective effects against reperfusion injury. Furthermore, we found that Ori treatment reversed neuronal mitochondrial damage and loss after reperfusion injury....
Source: Acta Pharmacologica Sinica - October 10, 2022 Category: Drugs & Pharmacology Authors: Lei Li Jing-Jing Song Meng-Xue Zhang Hui-Wen Zhang Hai-Yan Zhu Wei Guo Cai-Long Pan Xue Liu Lu Xu Zhi-Yuan Zhang Source Type: research

Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents
In this study we compared the cell composition of COs at different culture time and explored the cell types, cell ratios and volume size of COs at 85 days (85 d-CO). The 85 d-CO with diameter more than 2 mm was chosen for establishing humanized ischemic stroke model of OGD. By determining the time-injury relationship of the model, we observed aggravated ischemic injury of COs with OGD exposure time, obtaining first-hand evidence for the damage degree of COs under different OGD condition. The sensitivity of the model to ischemic injury and related treatment was validated by the proven pan-Caspase inhibitor Z-VAD-FMK (20 μM...
Source: Acta Pharmacologica Sinica - September 13, 2022 Category: Drugs & Pharmacology Authors: Shu-Na Wang Zhi Wang Xi-Yuan Wang Xiu-Ping Zhang Tian-Ying Xu Chao-Yu Miao Source Type: research

Low-dose nifedipine rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice
In conclusion, low-dose nifedipine can enhance EPCs' angiogenic potential and protect against cerebral ischemic injury in diabetic mice. It is implied that chronic treatment with low-dose nifedipine may be a safe and economic manner to prevent ischemic diseases (including stroke) in diabetes.PMID:35882957 | DOI:10.1038/s41401-022-00948-w
Source: Acta Pharmacologica Sinica - July 26, 2022 Category: Drugs & Pharmacology Authors: Cheng Peng Li-Jun Yang Chuan Zhang Yu Jiang Liu-Wen-Xin Shang Jia-Bei He Zhen-Wei Zhou Xia Tao Lu Tie Alex F Chen He-Hui Xie Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

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