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235 Association of stroke with psoriasis in end-stage renal disease patients
Previous research in the general population suggests that the inflammatory skin disease psoriasis is associated with an increased risk of vascular events, such as stroke. Thus, psoriasis may also represent a significant risk factor for stroke in dialysis patients. We queried the United States Renal Data System for incident dialysis patients between 2004 and 2015. Psoriasis was defined as having at least two ICD-9 or ICD-10 diagnosis codes. ICD codes were also used to query the outcome of interest, stroke, as well as other clinical risk factors.
Source: Journal of Investigative Dermatology - April 19, 2021 Category: Dermatology Authors: N. Siddiquee, J. Waller, S. Baer, M. Kheda, A. Mohammed, S. Padala, B. Siddiqui, L. Young, S. Tran, W. Bollag Tags: Patient Population Research Source Type: research

532 Shingles and post-herpetic neuralgia (PHN) in post-stroke patients: Real-world evidence
Shingles, known as zoster or herpes zoster, is a neurotropic viral disease featured with painful dermatomal skin eruptions, which leads to a notorious complication, post-herpetic neuralgia (PHN). PHN are usually refractory to treatment and disturbs patients' life. Among the world, stroke is a main cause of morbidity and mortality. Since patients are prone to get infectious diseases during acute phase following stroke, this study is aimed to investigate whether stroke increases the risk of shingles and it's terrible complication, PHN.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: C. Wu, Y. Lu Source Type: research

469 Evidence of a causal relationship between stroke and psoriasis
Comorbid cardiovascular disease (including coronary artery disease [CAD] and stroke) is a major source of morbidity and mortality in people with psoriasis. A recent Mendelian randomization (MR) study has provided supportive evidence that lifetime risk of CAD is causally implicated in psoriasis development, independent of adiposity (Patricket al Nat Commun. 2022). However, it is currently unclear whether lifetime risk of stroke influences psoriasis risk. A two-sample MR approach was undertaken to evaluate the putative causal effect of stroke on psoriasis risk.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith Source Type: research

The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox
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Source: Journal of Investigative Dermatology - September 11, 2015 Category: Dermatology Authors: Michael J VidoAndrew E Aplin Source Type: research

617 Generation of immortalized sweat gland myoepithelial cells and eccrine sweat gland research model
The increased incidence of heat stroke is caused by reduced sweating as a result of failures in tissue homeostasis that occur with aging. Specifically, tissue homeostasis is disrupted by the exhaustion of stem cells. We previously revealed that myoepithelial cells are the stem cells of sweat glands, thereby heat stroke can be avoided by preventing myoepithelial cell loss. Although myoepithelial cells serve as a useful tool for revealing their depletion, only a single strain of sweat gland cells, NCL-SG3, can differentiate into mature cells in adherent culture conditions.
Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: T. Hayakawa, R. Kurata, F. Fujita, F. Okada, K. Sekiguchi Tags: Stem Cells, Skin Appendages and Tissue Regeneration Source Type: research

028 Psychiatric and neurological disorders are associated with bullous pemphigoid – nationwide Finnish Care Register study
Bullous pemphigoid (BP) is an autoimmune blistering skin disease of the elderly with increasing incidence. BP has been shown to be associated with neurological disorders. So far, it has not been exactly established, for example, what subtypes of dementia and stroke are associated with BP, and what is the temporal relation between these diseases. Also, the association between BP and psychiatric disorders has remained controversial in previous studies. To answer these questions, we conducted a retrospective nationwide study using the statutory Finnish Care Register diagnoses between 1987 and 2013.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: A. F örsti, J. Jokelainen, H. Ansakorpi, A. Seppänen, K. Majamaa, M. Timonen, K. Tasanen Tags: Clinical Outcomes Source Type: research

575 Rapid changes in the red meat and α-Gal specific IgE-RAST level profile in the clinical course of a case with red meat allergy and Haemaphysalis longicornis bite
A case with stroke was referred to our hospital with two ticks attached on her right arm. Five days after admission, she started slurry food including red meat, and developed generalized urticarial rash. Then, she was diagnosed having urticarial allergic reaction to red meat, and red meat was eliminated from her hospital diet. The eruption disappeared within 3 days without systemic corticosteroid therapy. Her rash didn ’t recur during 4 months hospitalization. High prevalence of urticarial type red meat allergy was reported in the endemic area of Japanese spotted fever, which is mediated by Haemaphysalis longicornis (H.
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: M. Kondo, K. Yamanaka, H. Mizutani Tags: Innate Immunity, Microbiology, Inflammation Source Type: research

830 Fabry rat skin findings demonstrate potential roles of inflammation and lipoatrophy in Fabry disease
Fabry disease is an X-linked lysosomal disease caused by α-galactosidase A deficiency. Patients experience distal extremity pain and often develop renal failure, cardiomyopathy, and stroke. Dermatological manifestations include sweating abnormalities and angiokeratomas. To gain a better understanding of disease mechanisms, we generated a Fabry rat model using CRISPR/Cas9 technology and confirmed the absence of α-galactosidase A activity in tissues. Wild type (WT) and Fabry rats were indistinguishable at young ages (weaning-6 months), but aging (9 months+) Fabry rats developed an unkempt appearance, alopecia, and xeroderma.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: J.J. Miller, O. Sokumbi, P.E. North, N.M. Dahms Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

755 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels which lead to disfigurement, overgrowth, stroke, pain and/or life-threatening bleeding, depending on the vessel size and the body site. Therapeutic options are severely limited and multi-disciplinary management remains challenging. To investigate the pathogenesis of 160 sporadic intracranial and extracranial VMs in which known genetic causes had been excluded, sequencing of affected tissue DNA was undertaken using next generation sequencing optimised for detection of low mutant allele frequency.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: S. Polubothu, L. Al-Olabi, K. Dowsett, K. Andrews, P. Stadnik, R. Knox, W. Baird, M. Glover, C. Moss, A. Thomas, L. Biesecker, R. Semple, E. Patton, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

096 Demographic and serologic features differentiate bullous pemphigoid with and without preceding neurologic disease
This study aimed to identify features that may differentiate BP patients with and without neurologic disease. 105 patients with BP were enrolled in this study: 75 control BP patients with no neurologic disease (CON), 10 patients with BP and a prior diagnosis of Parkinson ’s disease (BP+PD), 11 BP with dementia patients (BP+DEM), and 9 BP with stroke (BP+STR).
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: A. Miller, K. Messingham, N. Narayanan, S. Connell, J. Fairley Tags: Adaptive and Auto-Immunity Source Type: research

830 Fabry rat skin findings demonstrate potential roles of inflammation and lipoatrophy in Fabry disease
Fabry disease is an X-linked lysosomal disease caused by α-galactosidase A deficiency. Patients experience distal extremity pain and often develop renal failure, cardiomyopathy, and stroke. Dermatological manifestations include sweating abnormalities and angiokeratomas. To gain a better understanding of disease mechanisms, we generated a Fabry rat model using CRISPR/Cas9 technology and confirmed the absence of α-galactosidase A activity in tissues. Wild type (WT) and Fabry rats were indistinguishable at young ages (weaning-6 months), but aging (9 months+) Fabry rats developed an unkempt appearance, alopecia, and xeroderma.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: J.J. Miller, O. Sokumbi, P.E. North, N.M. Dahms Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

755 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels which lead to disfigurement, overgrowth, stroke, pain and/or life-threatening bleeding, depending on the vessel size and the body site. Therapeutic options are severely limited and multi-disciplinary management remains challenging. To investigate the pathogenesis of 160 sporadic intracranial and extracranial VMs in which known genetic causes had been excluded, sequencing of affected tissue DNA was undertaken using next generation sequencing optimised for detection of low mutant allele frequency.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: S. Polubothu, L. Al-Olabi, K. Dowsett, K. Andrews, P. Stadnik, R. Knox, W. Baird, M. Glover, C. Moss, A. Thomas, L. Biesecker, R. Semple, E. Patton, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

096 Demographic and serologic features differentiate bullous pemphigoid with and without preceding neurologic disease
This study aimed to identify features that may differentiate BP patients with and without neurologic disease. 105 patients with BP were enrolled in this study: 75 control BP patients with no neurologic disease (CON), 10 patients with BP and a prior diagnosis of Parkinson ’s disease (BP+PD), 11 BP with dementia patients (BP+DEM), and 9 BP with stroke (BP+STR).
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: A. Miller, K. Messingham, N. Narayanan, S. Connell, J. Fairley Tags: Adaptive and Auto-Immunity Source Type: research

Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases
Bullous pemphigoid (BP) is an autoantibody-mediated blistering disease that is often associated with neurologic disease. BP antibodies target two epidermal adhesion molecules, known as BP180 and BP230. Homologues to these proteins are found in the brain, and it is hypothesized that neurologic disease leads to the production of autoantibodies that can cross react with their cutaneous forms. To better understand the link between BP and neurologic disease, we evaluated primary demographic features (age, sex, race, ethnicity and elapsed time between onset of skin symptoms and BP diagnosis), severity of BP, and IgG and IgE auto...
Source: Journal of Investigative Dermatology - March 11, 2019 Category: Dermatology Authors: Kelly N. Messingham, Adam D. Miller, Nandakumar S. Narayanan, Samuel J. Connell, Janet A. Fairley Tags: Original Article Source Type: research

817 Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency
Excessive alcohol consumption leads to alcohol use disorder. Alcohol is metabolized to acetaldehyde, which is then oxidized to acetic acid by aldehyde dehydrogenases (ALDH), a class of enzymes that facilitate the conversion of aldehydes to their corresponding acids. Among ALDHs, mitochondrial ALDH2 is the primary enzyme involved in the metabolism of acetaldehyde. In addition to its well-known role in ethanol metabolism, recent studies have suggested that ALDH2 dysfunction is associated with a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, cancer, anemia, pain, osteoporosis and aging.
Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: T. Yamauchi, A. Matsumoto, S. Ito, K. Wakamatsu, T. Suzuki, M. Fujita Tags: Pigmentation and Melanoma Source Type: research

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