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Source: Cancer Control
Vaccination: Cancer Vaccines
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Total 661 results found since Jan 2013.
Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines
Pharmaceutics. 2022 Dec 31;15(1):152. doi: 10.3390/pharmaceutics15010152.ABSTRACTInfectious diseases continue to be a leading cause of morbidity and mortality worldwide. The majority of infectious diseases are caused by intracellular pathogenic bacteria (IPB). Historically, conventional vaccination drives have helped control the pathogenesis of intracellular bacteria and the emergence of antimicrobial resistance, saving millions of lives. However, in light of various limitations, many diseases that involve IPB still do not have adequate vaccines. In response to increasing demand for novel vaccine development strategies, a ...
Source: Cancer Control - January 21, 2023 Category: Cancer & Oncology Authors: Muhammad Ajmal Khan Aftab Amin Awais Farid Amin Ullah Abdul Waris Khyber Shinwari Yaseen Hussain Khalaf F Alsharif Khalid J Alzahrani Haroon Khan Source Type: research
Fluorescence labeling of anchor modified Mart-1 peptide for increasing its affinity for HLA-A*0201: Hit two targets with one arrow
In this study, by fluorescence labeling of its either C- or N-terminus with Nε -(5-carboxyfluorescein)-L-lysine, we not only made it traceable but we also drastically increased its binding strength to HLA-A*0201. HLA streptamer, for the first time, is introduced for measuring the binding constants (Ka ) of the labeled peptides. The affinity of the labeled peptides for the HLA-A*201 of the MCF-7 cells was extraordinarily high and co-incubating them with the highest possible amount of the unlabeled peptide, as a competitor, did not significantly prohibit them from binding to the HLA. The reproducibility of the obtained resu...
Source: Cancer Control - January 20, 2023 Category: Cancer & Oncology Authors: Pooya Fattahi Najmeh Salehi Zahra Azizi Javad Mohammadi Amir Norouzy Seyed Mohammad Moazzeni Source Type: research
Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes
Infect Agent Cancer. 2023 Jan 19;18(1):3. doi: 10.1186/s13027-023-00480-4.ABSTRACTThe role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses. Moreover, these OMVs have a...
Source: Cancer Control - January 19, 2023 Category: Cancer & Oncology Authors: Saba Jalalifar Hassan Morovati Khamsi Seyed Reza Hosseini-Fard Sajad Karampoor Bahar Bajelan Gholamreza Irajian Rasoul Mirzaei Source Type: research
Effect of medical staff training on vaccination coverage in outpatients with cancer: An interventional multicenter before-and-after study
CONCLUSION: As expected, VC was very low in patients with cancer, consistent with the literature. There was no impact of the intervention for pneumococcal and influenza VC.PMID:36654840 | PMC:PMC9841025 | DOI:10.1016/j.jvacx.2023.100261
Source: Cancer Control - January 19, 2023 Category: Cancer & Oncology Authors: Pierre Rivi ère Nicolas Penel Karine Faure Guillaume Marie Abeer Najem Marie-Karelle Rivi ère Sophie Panaget Source Type: research
Functional T cells are capable of supernumerary cell division and longevity
Nature. 2023 Jan 18. doi: 10.1038/s41586-022-05626-9. Online ahead of print.ABSTRACTDifferentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans1-3. To provide immunity, transiently stimulated CD8+ T cells undergo unusually rapid bursts of numerous cell divisions, and then form quiescent long-lived memory cells that remain poised to reproliferate following subsequent immunological challenges. Here we addressed whether T cells are intrinsically constrained by chronological or cell-division limits. We activated mouse T cells in vivo using acute hete...
Source: Cancer Control - January 18, 2023 Category: Cancer & Oncology Authors: Andrew G Soerens Marco K ünzli Clare F Quarnstrom Milcah C Scott Lee Swanson J J Locquiao Hazem E Ghoneim Dietmar Zehn Benjamin Youngblood Vaiva Vezys David Masopust Source Type: research
The second HPV serology meeting: Progress and challenges in standardization of human papillomavirus serology assays
Vaccine. 2023 Jan 13:S0264-410X(23)00008-7. doi: 10.1016/j.vaccine.2023.01.008. Online ahead of print.ABSTRACTThe HPV Serology Laboratory in the Frederick National Laboratory for Cancer Research is working in partnership with the scientific community with the goal of standardizing and harmonizing current HPV serology assay platforms in response to the increasing number of immunobridging trials relying on serology data for approval of new vaccine dosing schedules and new formulations. A virtual meeting was held on June 29-30, 2021, to review the progress of the standardization initiative thus far and to bridge scientific ga...
Source: Cancer Control - January 15, 2023 Category: Cancer & Oncology Authors: Isabel Park Elizabeth R Unger Troy J Kemp Ligia A Pinto Source Type: research
Baculovirus-mediated expression of a Helicobacter pylori protein-based multiepitope hybrid gene induces a potent B cell response in mice
Immunobiology. 2023 Jan 9;228(2):152334. doi: 10.1016/j.imbio.2023.152334. Online ahead of print.ABSTRACTHelicobacter pylori is a gram-negative bacterium that is present in over half of the world's population. The colonization of the stomach́s gastric mucosa by H. pylori is related to the onset of chronic gastritis, peptic ulcer, and cancer. The estimated deaths from gastric cancer caused by this bacterial infection are in the 15,000-150,000 range. Current treatment for controlling the colonization of H. pylori includes the administration of two to four antibiotics and a gastric ATPase proton pump inhibitor. Nevertheless,...
Source: Cancer Control - January 15, 2023 Category: Cancer & Oncology Authors: Ana G Montiel-Mart ínez Roxana Y Vargas-Jer ónimo Tania Flores-Romero Jaime Moreno-Mu ñoz Carlos C Bravo-Reyna Ver ónica Luqueño-Martínez Mariela Contreras-Escamilla Jovani Zamudio-L ópez Susana Mart ínez-Rodríguez Fernanda Barr án-Sánchez Juan Source Type: research
Updated epidemiology of gastrointestinal cancers in East Asia
Nat Rev Gastroenterol Hepatol. 2023 Jan 11. doi: 10.1038/s41575-022-00726-3. Online ahead of print.ABSTRACTGlobally, gastrointestinal cancers represent more than one-fourth of all cancer incidence and one-third of cancer-related mortality. Although there has been much progress in screening colorectal cancer, the prognosis of other gastrointestinal cancers tends to be poor. The highest burden of gastrointestinal cancers, including stomach, liver, oesophageal and gallbladder cancers, was observed in regions in East Asia. The increasing burden of gastrointestinal cancers in East Asian regions is related to population growth, ...
Source: Cancer Control - January 11, 2023 Category: Cancer & Oncology Authors: Junjie Huang Don Eliseo Lucero-Prisno Lin Zhang Wanghong Xu Sunny H Wong Siew C Ng Martin C S Wong Source Type: research
Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection
Sci Rep. 2023 Jan 9;13(1):393. doi: 10.1038/s41598-023-27400-1.ABSTRACTSalmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice. The Collaborative Cross (CC) is a large panel of recombinant inbred strains which has a wider range of genetic diversity than laboratory inbred mouse strains. We found that the CC003/Unc and CC053/Unc strains are permissive to intraperitoneal but not oral route of S. Typhi infection and show histopatholog...
Source: Cancer Control - January 9, 2023 Category: Cancer & Oncology Authors: Kishore R Alugupalli Sudeep Kothari Matthew P Cravens Justin A Walker Darren T Dougharty Gregory S Dickinson Louis A Gatto Andreas J B äumler Tamding Wangdi Darla R Miller Fernando Pardo-Manuel de Villena Linda D Siracusa Source Type: research
Stimulation of the immune system by a tumor antigen-bearing adenovirus-inspired VLP allows control of melanoma growth
Mol Ther Methods Clin Dev. 2022 Dec 7;28:76-89. doi: 10.1016/j.omtm.2022.12.003. eCollection 2023 Mar 9.ABSTRACTVirus-like particles (VLPs) are versatile protein-based platforms that can be used as a vaccine platform mainly in infectiology. In the present work, we compared a previously designed, non-infectious, adenovirus-inspired 60-mer dodecahedric VLP to display short epitopes or a large tumor model antigen. To validate these two kinds of platforms as a potential immuno-stimulating approach, we evaluated their ability to control melanoma B16-ovalbumin (OVA) growth in mice. A set of adjuvants was screened, showing that p...
Source: Cancer Control - January 9, 2023 Category: Cancer & Oncology Authors: Sol ène Besson Emilie Boucher David Laurin Olivier Manches Caroline Aspord Dalil Hannani Pascal Fender Source Type: research
Human IL-10-producing Th1 cells exhibit a molecular signature distinct from Tr1 cells in malaria
J Clin Invest. 2023 Jan 3;133(1):e153733. doi: 10.1172/JCI153733.ABSTRACTControl of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However, these IL-10-producing Th1 (induced type I regulatory [Tr1]) cells can also promote parasite persistence or impair immunity to reinfection or vaccination. Here, we identified molecular and phenotypic signatures that distinguished IL-10-Th1 cells from IL-10+Tr1 cells in Plasmodium falciparum-infected people who participated in controlled h...
Source: Cancer Control - January 3, 2023 Category: Cancer & Oncology Authors: Chelsea L Edwards Susanna S Ng Fabian de Labastida Rivera Dillon Corvino Jessica A Engel Marcela Montes de Oca Luzia Bukali Teija Cm Frame Patrick T Bunn Shashi Bhushan Chauhan Siddharth Sankar Singh Yulin Wang Jinrui Na Fiona H Amante Jessica R Loughland Source Type: research
CagA-specific gastric CD8 < sup > + < /sup > tissue-resident T cells control Helicobacter pylori during the early infection phase
CONCLUSIONS: Our results point towards a hitherto unknown role of CD8+ T cell response in this bacterial infection, which may have important clinical implications for treatment and vaccination strategies against H. pylori.PMID:36587707 | DOI:10.1053/j.gastro.2022.12.016
Source: Cancer Control - January 1, 2023 Category: Cancer & Oncology Authors: Maximilian R Koch Ruolan Gong Verena Friedrich Veronika Engelsberger Lorenz Kretschmer Andreas Wanisch Sebastian Jarosch Anna Ralser Bob Lugen Michael Quante Michael Vieth Riccardo Vasapolli Christian Schulz Veit R Buchholz Dirk H Busch Raquel Mej ías-Lu Source Type: research
Use of Conditioned Extracellular Matrix as a Tissue-engineered Tumor Matrisome for Prostate Cancer and Melanoma Immunotherapy
CONCLUSION: Antigens within the tissue-engineered matrisome stimulated an inhibitory response to tumor growth; this strategy should be explored further as a means of cancer immunotherapy.PMID:36585187 | DOI:10.21873/anticanres.16168
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Mark A Suckow Michael C Hiles Source Type: research
Attitudes toward COVID-19 vaccination during the state of emergency in Osaka, Japan
CONCLUSIONS: Most respondents expressed favorable attitudes toward COVID-19 vaccination while hesitancy was disproportionately high in certain populations. Efforts are needed to ensure accessible vaccine information resources and healthcare services.PMID:36584068 | PMC:PMC9803118 | DOI:10.1371/journal.pone.0279481
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Satomi Odani Shihoko Koyama Yuichi Katsumi Isao Miyashiro Source Type: research
Immune responses to SARS-CoV-2 in vaccinated patients receiving checkpoint blockade immunotherapy for cancer
Front Immunol. 2022 Dec 13;13:1022732. doi: 10.3389/fimmu.2022.1022732. eCollection 2022.ABSTRACTVaccination against SARS-CoV-2 has been successful in protecting patients with cancer from severe infections, but how immune responses against COVID-19 vaccination interact with those elicited during cancer immunotherapy has not been fully described. Immune checkpoint blockade (ICB) disrupts inhibitory pathways in immune cells to improve function and induce tumor immunity but can often cause serious immune related adverse events (IRAEs). Because COVID-19 vaccination and ICB both boost immune responses, it is imperative to under...
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Alexander Piening Emily Ebert Niloufar Khojandi Elise Alspach Ryan M Teague Source Type: research
