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Source: Cardiovascular Diabetology

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Total 81 results found since Jan 2013.

GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
Glucagon-like peptide-1 (GLP-1) treatment has been shown to reduce stroke incidence in diabetes and also to be neuroprotective in experimental stroke models. The prognostic value of endogenous levels of GLP-1 ...
Source: Cardiovascular Diabetology - July 15, 2019 Category: Cardiology Authors: Martin Larsson, Cesare Patrone, Mia von Euler, Jens J. Holst and David Nathanson Tags: Original investigation Source Type: research

The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes
Hypertension is one of the strongest risk factors for stroke in the general population, while systolic blood pressure has been shown to independently increase the risk of stroke in type 1 diabetes. The aim of ...
Source: Cardiovascular Diabetology - July 9, 2019 Category: Cardiology Authors: Stefanie H ägg-Holmberg, Emma H. Dahlström, Carol M. Forsblom, Valma Harjutsalo, Ron Liebkind, Jukka Putaala, Turgut Tatlisumak, Per-Henrik Groop and Lena M. Thorn Tags: Original investigation Source Type: research

Effect of pioglitazone in acute ischemic stroke patients with diabetes mellitus: a nested case –control study
Pioglitazone is an oral antidiabetic drug with multiple pleiotropic actions. Recent clinical trials have demonstrated that treatment with pioglitazone reduces cardiovascular risk in patients who have had an is...
Source: Cardiovascular Diabetology - May 31, 2019 Category: Cardiology Authors: Min-Hee Woo, Hye Sun Lee and Jinkwon Kim Tags: Original investigation Source Type: research

Concerns about clinical efficacy and safety of warfarin in diabetic patients with atrial fibrillation
Atrial fibrillation (AF) is one of the most common arrhythmias in elderly people. The risk of thromboembolic stroke is increased in AF patients, especially those with diabetes. Anticoagulant therapy, such as w...
Source: Cardiovascular Diabetology - January 28, 2019 Category: Cardiology Authors: Sho-ichi Yamagishi Tags: Commentary Source Type: research

The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1 α/CXCR4 pathway
Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-...
Source: Cardiovascular Diabetology - May 19, 2018 Category: Cardiology Authors: Fausto Chiazza, Harald Tammen, Hiranya Pintana, Grazyna Lietzau, Massimo Collino, Thomas Nystr öm, Thomas Klein, Vladimer Darsalia and Cesare Patrone Tags: Original investigation Source Type: research

The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study
The effect of change in blood glucose levels on the risk of cardiovascular disease among individuals without diabetes is currently unclear. We aimed to examine the association of change in fasting serum glucos...
Source: Cardiovascular Diabetology - April 7, 2018 Category: Cardiology Authors: Gyeongsil Lee, Sung Min Kim, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun and Sang Min Park Tags: Original investigation Source Type: research

The high need for trials assessing functional outcome after stroke rather than stroke prevention with GLP-1 agonists and DPP-4 inhibitors
Source: Cardiovascular Diabetology - February 21, 2018 Category: Cardiology Authors: Vladimer Darsalia, Martin Larsson, Thomas Klein and Cesare Patrone Tags: Commentary Source Type: research

Linagliptin and cardiovascular outcomes in type 2 diabetes after acute coronary syndrome or acute ischemic stroke
The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) ar...
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Yan-Rong Li, Sung-Sheng Tsai, Dong-Yi Chen, Szu-Tah Chen, Jui-Hung Sun, Hung-Yu Chang, Miaw-Jene Liou and Tien-Hsing Chen Tags: Original investigation Source Type: research

Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes
Attenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricul...
Source: Cardiovascular Diabetology - December 19, 2017 Category: Cardiology Authors: Genevieve A. Wilson, Gerard T. Wilkins, Jim D. Cotter, Regis R. Lamberts, Sudish Lal and James C. Baldi Tags: Original investigation Source Type: research

Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) might aggravate the carotid plaque vulnerability, and increase the risk for ischemic stroke. Few studies reported the acute stroke subtype with carotid plaque characteristics in...
Source: Cardiovascular Diabetology - September 11, 2017 Category: Cardiology Authors: Beibei Sun, Xiao Li, Xiaosheng Liu, Xiaoqian Ge, Qing Lu, Xihai Zhao, Jun Pu, Jianrong Xu and Huilin Zhao Tags: Original investigation Source Type: research

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels
The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remo...
Source: Cardiovascular Diabetology - November 10, 2016 Category: Cardiology Authors: Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor and Cristina Murga Source Type: research

Achievement of treatment goals for secondary prevention of myocardial infarction or stroke in 29,325 patients with type 2 diabetes: a German/Austrian DPV-multicenter analysis
To analyze whether medical care is in accordance with guidelines for secondary prevention of myocardial infarction (MI), or stroke in patients with type 2 diabetes from Germany and Austria.
Source: Cardiovascular Diabetology - May 3, 2016 Category: Cardiology Authors: Barbara Bohn, Christof Schöfl, Vincent Zimmer, Michael Hummel, Nikolai Heise, Erhard Siegel, Wolfram Karges, Michaela Riedl and Reinhard W. Holl Source Type: research

Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus
Background: Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients. Methods: A total of 247 T2DM patients without history of cardiovascular complications and participated in the CDATS study were prospectively enrolled. Left ventricular (LV) systolic function was assessed by LV ejection fraction and speckle tracking derived LV systolic GLS. Diastolic function was assessed by E/E′ ratio defined as the passive trans-mitral LV inflow velocity to tissue Doppler imaging velo...
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Ju-Hua LiuYan ChenMichele YuenZhe ZhenCarmen ChanKaren LamHung-Fat TseKai-Hang Yiu Source Type: research

Early cardiovascular events in women with a history of gestational diabetes mellitus
Conclusions: A history of GDM was identified as a risk factor of CVD, especially coronary vascular diseases, within the 7 years postpartum. A lifestyle changes from postpartum onwards can be recommended and supported.
Source: Cardiovascular Diabetology - January 27, 2016 Category: Cardiology Authors: Karine GoueslardJonathan CottenetAnne-Sophie MarietMaurice GiroudYves CottinJean-Michel PetitCatherine Quantin Source Type: research

Lower-extremity amputation as a marker for renal and cardiovascular events and mortality in patients with long standing type 1 diabetes
Background: We evaluated the risks of renal and cardiovascular complications, and mortality associated with lower extremity amputation (LEA) in patients with type 1 diabetes. Methods: We studied two cohorts of people with long standing type 1 diabetes: GENEDIAB (n = 456) and GENESIS (n = 611). Subsets of the cohorts (n = 260, n = 544) were followed for 9 and 5 years, respectively. Outcomes were the incidence of end stage renal disease (ESRD), myocardial infarction, stroke and mortality during follow-up. Analyses were performed in pooled cohorts. Results: The prevalence of LEA at baseline was 9.3 % (n = 99). A p...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Kamel MohammediLouis PotierNarimène BelhatemNadia MatallahSamy HadjadjRonan RousselMichel MarreGilberto Velho Source Type: research