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Specialty: Internal Medicine
Source: Journal of Internal Medicine

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Total 67 results found since Jan 2013.

Ceruloplasmin dysfunction: a key factor in the pathophysiology of atrial fibrillation?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - November 5, 2013 Category: Internal Medicine Authors: Jamie Y Jeremy, Nilima Shukla Tags: Editorial Comment Source Type: research

Environmental pollutants: downgrading the fish food stock affects chronic disease risk
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - January 22, 2014 Category: Internal Medicine Authors: David R. Jacobs, Jerome Ruzzin, Duk‐Hee Lee Tags: Editorial Comment Source Type: research

Is age‐related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - February 1, 2014 Category: Internal Medicine Authors: Gemmy Chui Ming Cheung, Wong Tien Yin Tags: Review Source Type: research

The collagen cross‐linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions
ConclusionsLOX may contribute to the healing of atherosclerotic lesions and to prevention of its lethal complications. Mediators of inflammation may control LOX expression in plaques and hence plaque stability.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - February 1, 2014 Category: Internal Medicine Authors: Olga A. Ovchinnikova, Lasse Folkersen, Jonas Persson, Jan H. N. Lindeman, Thor Ueland, Pål Aukrust, Natalya Gavrisheva, Eugene Shlyakhto, Gabrielle Paulsson‐Berne, Ulf Hedin, Peder S. Olofsson, Göran K. Hansson Tags: Original Source Type: research

Soluble urokinase plasminogen activator receptor levels are elevated and associated with complications in patients with type 1 diabetes
ConclusionThe suPAR level is higher in patients with type 1 diabetes, and is associated with diabetes duration and complications independent of other risk factors. suPAR is a potential novel risk marker for the management of diabetes.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - May 15, 2014 Category: Internal Medicine Authors: Simone Theilade, Stig Lyngbæk, Tine W. Hansen, Jesper Eugen‐Olsen, Mogens Fenger, Peter Rossing, Jørgen L. Jeppesen Tags: Original Source Type: research

The emerging role of microRNAs in cardiovascular disease
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - August 27, 2014 Category: Internal Medicine Authors: Lars Maegdefessel Tags: Review Source Type: research

Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross‐sectional study
ConclusionsMeasures of atherosclerotic burden are associated with clinically manifest CVD in subjects with T2D. In addition, vascular changes that are not directly related to known metabolic risk factors are important in the development of both atherosclerosis and CVD in T2D. A better understanding of the mechanisms involved is crucial for enabling better identification of CVD risk in T2D.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - March 9, 2015 Category: Internal Medicine Authors: Angela C. Shore, Helen M. Colhoun, Andrea Natali, Carlo Palombo, Gerd Östling, Kunihiko Aizawa, Cecilia Kennbäck, Francesco Casanova, Margaretha Persson, Kim Gooding, Phillip E. Gates, Faisel Kahn, Helen C. Looker, Fiona Adams, Jill Belch, Silvia Pinnol Tags: Original Article Source Type: research

No association between adherence to the healthy Nordic food index and cardiovascular disease amongst Swedish women: a cohort study
ConclusionThe present results do not support an association between a healthy Nordic food index and risk of cardiovascular disease in Swedish women. There was also no effect modification by alcohol intake, BMI or age. Our finding of an interaction with smoking status requires reproduction.
Source: Journal of Internal Medicine - May 19, 2015 Category: Internal Medicine Authors: N. Roswall, S. Sandin, R. Scragg, M. Löf, G. Skeie, A. Olsen, H.‐O. Adami, E. Weiderpass Tags: Original Article Source Type: research

Role of exosomes and microvesicles in hypoxia‐associated tumour development and cardiovascular disease
Abstract Exosomes and microvesicles, collectively referred to as extracellular vesicles (EVs), can transfer complex biological information and induce a diverse signalling response in recipient cells with potential relevance in a wide array of pathological conditions. Tissue hypoxia constitutes a stress‐associated phenotype that is central to the malignant state of aggressive tumours as well as to ischaemic tissue in cardiovascular disorders. The adaptive response to hypoxic stress is largely dependent on intercellular communication in which EVs, and cellular exchange of EV cargo molecules, have recently been implicated. ...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: M. Belting, H. C. Christianson Tags: Review Source Type: research

Gene expression signatures, pathways and networks in carotid atherosclerosis
ConclusionsOur findings confirmed a central role for inflammation and proteases in plaque instability, and highlighted haemoglobin metabolism and bone resorption as important pathways. Subgroup analysis suggested prolonged inflammation following the symptoms of plaque instability and calcification as a possible stabilizing mechanism by statins. In addition, transcriptional regulation may play an important role in the determination of plaque phenotype. The results from this study will serve as a basis for further exploration of molecular signatures in carotid atherosclerosis.
Source: Journal of Internal Medicine - December 1, 2015 Category: Internal Medicine Authors: L. Perisic, S. Aldi, Y. Sun, L. Folkersen, A. Razuvaev, J. Roy, M. Lengquist, S. Åkesson, C. E. Wheelock, L. Maegdefessel, A. Gabrielsen, J. Odeberg, G. K. Hansson, G. Paulsson‐Berne, U. Hedin Tags: Original Article Source Type: research

The glycocalyx and its significance in human medicine
Abstract Cells are covered by a surface layer of glycans that is referred to as the ‘glycocalyx’. In this review, we focus on the role of the glycocalyx in vascular diseases (atherosclerosis, stroke, hypertension, kidney disease and sepsis) and cancer. The glycocalyx and its principal glycosaminoglycans [heparan sulphate (HS) and hyaluronic acid (HA)] and core proteins (syndecans and glypicans) are degraded in vascular diseases, leading to a breakdown of the vascular permeability barrier, enhanced access of leucocytes to the arterial intima that propagate inflammation and alteration of endothelial mechanotransduction m...
Source: Journal of Internal Medicine - January 8, 2016 Category: Internal Medicine Authors: J. M. Tarbell, L. M. Cancel Tags: Review Source Type: research

Circulating calcium concentrations, vascular disease and mortality: a systematic review
Abstract Associations between serum calcium and vascular disease have been reported, but the consistency of these findings is unknown. We conducted a systematic review to determine whether circulating calcium concentrations are associated with risks of cardiovascular disease and death in normocalcaemic populations. We conducted PubMed searches up to 18 December 2014 and scrutinized reference lists of papers. Eligible studies related serum calcium to mortality or cardiovascular events in humans. A follow‐up of at least one year was required for longitudinal studies. Studies in populations selected on the basis of renal di...
Source: Journal of Internal Medicine - January 8, 2016 Category: Internal Medicine Authors: I. R. Reid, G. D. Gamble, M. J. Bolland Tags: Review Source Type: research

Tailored treatment strategies: a new approach for modern management of atrial fibrillation
Abstract Atrial fibrillation (AF) is not benign. Cardiovascular diseases and risk factors differ importantly amongst patients. Careful phenotyping with the aim to start tailored therapy may improve outcome and quality of life. Furthermore, structural remodelling plays an important role in initiation and progression of AF. Therapies that interfere in the remodelling processes are promising because they may modify the atrial substrate. However, success is still limited probably due to variations in the underlying substrate in individual patients. The most favourable effects of lifestyle changes on success of rhythm control h...
Source: Journal of Internal Medicine - March 16, 2016 Category: Internal Medicine Authors: I. C. Gelder, A. H. Hobbelt, E. G. Marcos, U. Schotten, R. Cappato, T. Lewalter, J. Schwieler, M. Rienstra, G. Boriani Tags: Review Source Type: research

Psychosocial stress and major cardiovascular events in patients with stable coronary heart disease
ConclusionsPsychosocial stress, such as depressive symptoms, loss of interest, living alone, and financial stress, was associated with increased CV mortality in patients with stable CHD despite optimal medical secondary prevention treatment. Secondary prevention of CHD should therefore focus also on psychosocial issues both in clinical management and in future clinical trials.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 28, 2017 Category: Internal Medicine Authors: Emil Hagstr öm, Fredrika Norlund, Amanda Stebbins, Paul W Armstrong, Karen Chiswell, Christopher B Granger, José López‐Sendón, Daniel Pella, Joseph Soffer, Rody Sy, Lars Wallentin, Harvey D White, Ralph A H Stewart, Claes Held, Tags: Original Source Type: research

Comparison of Bleeding Risk Scores in Patients with Atrial Fibrillation:Insights from the RE ‐LY Trial
ConclusionsAmong the current clinical bleeding risk scores, the ORBIT score demonstrated the best discrimination and calibration. All the scores demonstrated, to a variable extent, an interaction with bleeding risk associated with dabigatran or warfarin.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 16, 2017 Category: Internal Medicine Authors: Marco Proietti, Ziad Hijazi, Ulrika Andersson, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Deirdre A. Lane, Jonas Oldgren, Vanessa Roldan, Salim Yusuf, Lars Wallentin, Tags: Original Source Type: research