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Specialty: Child Development
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Total 100 results found since Jan 2013.
The aetiology of neonatal seizures and the diagnostic contribution of neonatal cerebral magnetic resonance imaging
AimThe aim of this study was to delineate aetiologies and explore the diagnostic value of cerebral magnetic resonance imaging (MRI) in addition to cranial ultrasonography (cUS) in infants presenting with neonatal seizures.
MethodThis retrospective cohort study comprised infants (gestational age 35.0–42.6wks) with seizures, confirmed by either continuous amplitude‐integrated electroencephalography (aEEG) or standard EEG and admitted during a 14‐year period to a level three neonatal intensive care unit (n=378; 216 males, 162 females; mean [SD] birthweight 3334g [594]). All infants underwent cUS and MRI (MRI on median o...
Source: Developmental Medicine and Child Neurology - November 11, 2014 Category: Child Development Authors: Lauren C Weeke, Floris Groenendaal, Mona C Toet, Manon J N L Benders, Rutger A J Nievelstein, Linda G M Rooij, Linda S Vries Tags: Original Article Source Type: research
Are children with acute arterial ischaemic stroke eligible for hyperacute thrombolysis? A retrospective audit from a tertiary UK centre
AimThe aim of this study was to evaluate the number of children with acute arterial ischaemic stroke (AIS) who would have been eligible for hyperacute thrombolysis in the authors' unit (Great Ormond Street Hospital, London, UK) and to identify barriers to this treatment.
MethodWe compared the characteristics of children with a diagnosis of acute AIS, identified from neuroimaging databases, seen at our centre between January 2006 and December 2011. The criteria for hyperacute thrombolysis were predefined by us: age ≥8y; imaging‐confirmed diagnosis of acute AIS and arrival at our centre within 6 hours of symptom onset; ...
Source: Developmental Medicine and Child Neurology - September 18, 2014 Category: Child Development Authors: Clara Marecos, Roxana Gunny, Robert Robinson, Vijeya Ganesan Tags: Original Article Source Type: research
Determination of interventions for upper extremity tactile impairment in children with cerebral palsy: a systematic review
This study reviewed interventions suitable for treating tactile dysfunction in children with cerebral palsy (CP).
MethodA systematic review was conducted of six databases, searched for population: (‘brain injury’ OR ‘cerebral palsy’ OR ‘stroke’ OR ‘cerebrovascular accident’) and intervention: (‘tactile’ OR ‘sensation’). Inclusion criteria were: (1) published after 1950 in English; (2) participants older than 4 years with brain injury; (3) upper limb intervention; and (4) examined tactile registration or perception.
ResultsOf 2938 studies identified, 30 met the inclusion criteria. Results from inclu...
Source: Developmental Medicine and Child Neurology - March 26, 2014 Category: Child Development Authors: Megan L Auld, Remo Russo, G Lorimer Moseley, Leanne M Johnston Tags: Review Source Type: research
Post‐stroke epilepsy in Polish paediatric patients
AimThe aim of this study was to characterize a group of children with early and late remote seizures which occurred after arterial ischaemic stroke (AIS) and to find predictors of post‐stroke seizures.
MethodThe study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 patients who had had a stroke: 13 patients had early seizures occurring up to 7 days after the stroke, seven patients had late remote seizures occurring more than 7 days after the stroke, and 58 patients had no seizure. Univariate log‐rank tests and Cox proportional hazard models were us...
Source: Developmental Medicine and Child Neurology - October 5, 2013 Category: Child Development Authors: Ilona Kopyta, Beata Sarecka‐Hujar Tags: Original Article Source Type: research
Neuropsychological and neurobehavioral outcome following childhood arterial ischemic stroke: Attention deficits, emotional dysregulation, and executive dysfunction.
Conclusions. A significant proportion of children poststroke are at long-term risk of difficulties with emotional regulation, executive function, and attention. Data also suggest that executive functions are represented in widespread networks in the developing brain and are vulnerable to unilateral injury.
PMID: 24028185 [PubMed - as supplied by publisher]
Source: Child Neuropsychology - September 13, 2013 Category: Child Development Authors: O'Keeffe F, Liégeois F, Eve M, Ganesan V, King J, Murphy T Tags: Child Neuropsychol Source Type: research
Neonatal neuroimaging predicts recruitment of contralesional corticospinal tracts following perinatal brain injury
AimUnilateral perinatal brain injury may result in recruitment of ipsilateral projections originating in the unaffected hemisphere and development of unilateral spastic cerebral palsy (USCP). The aim of this study was to assess the predictive value of neonatal neuroimaging following perinatal brain injury for recruitment of ipsilateral corticospinal tracts.
MethodNeonatal magnetic resonance imaging (MRI) and cranial ultrasound scans of 37 children (20 males, 17 females; median [range] gestational age 36 wks+4 [26+6–42wks+5] and birthweight 2312 g ([770–5230g]) with unilateral perinatal arterial ischaemic stroke (n=23) ...
Source: Developmental Medicine and Child Neurology - May 6, 2013 Category: Child Development Authors: Niek E Aa, Cornelia H Verhage, Floris Groenendaal, R Jeroen Vermeulen, Stella Bode, Onno Nieuwenhuizen, Linda S Vries Tags: Original Article Source Type: research
Basilar artery strokes in children: good outcomes with conservative medical treatment
AimTo describe outcomes and outcome predictors in childhood basilar artery stroke (BAS).
MethodWe prospectively enrolled children with BAS with or without basilar artery occlusion (BAO) in the Toronto Children's Stroke Registry from 1992 to 2009. We assessed presenting features and outcomes including Pediatric Stroke Outcome Measure scores.
ResultsAmong 578 children with acute arterial ischemic stroke, 27 had BAS (4.6% including neonates, 6% excluding neonates). Twenty‐four (14 males, 10 females) children met study criteria (mean age at stroke was 8y 10mo; range 0–17y). Eleven children had BAO. Aspirin or anticoagulati...
Source: Developmental Medicine and Child Neurology - February 17, 2013 Category: Child Development Authors: Ana Marissa Lagman‐Bartolome, Ann‐Marie Pontigon, Mahendranath Moharir, Daune L. Macgregor, Rand Askalan, Ivanna Yau, Gabrielle Deveber Tags: Original Article Source Type: research
The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada
AimTo determine the epidemiology of chronic ataxia in children in Manitoba, Canada.
MethodA retrospective study using multiple sources and disease codes identified children (age 0–16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children's Hospital from 1991 to 2008. Patients with isolated peripheral nerve diseases, vestibular disorders, or brain tumors were excluded.
ResultsWe identified 184 patients (males=females; mean age 15y, SD 7y 8mo) with chronic ataxia. Median age at the presenting symptom onset was 1 year 3 months and at ataxia onset 3 years 1 month. Median durati...
Source: Developmental Medicine and Child Neurology - February 7, 2013 Category: Child Development Authors: Michael S Salman, Esther J Lee, Anindita Tjahjadi, Bernard N Chodirker Tags: Original Article Source Type: research
Reproducibility of two functional field exercise tests for children with cerebral palsy who self‐propel a manual wheelchair
AimThe aim of this study was to examine the test–retest reproducibility (reliability and agreement) of the 6‐minute push test (6MPT) and the one‐stroke push test (1SPT), and construct validity of the 6MPT in children with cerebral palsy (CP) who self‐propel a manual wheelchair.
MethodSeventy‐three children and adolescents with spastic CP (51 males, 22 females; mean age 11y 9mo, SD 3y 7mo, range 4–18y; three unilateral, 70 bilateral) using a manual wheelchair for at least part of the day were recruited from and tested in different rehabilitation settings in the Netherlands and Brazil. Participants were classifie...
Source: Developmental Medicine and Child Neurology - December 18, 2012 Category: Child Development Authors: Olaf Verschuren, Marjolijn Ketelaar, Janke De Groot, FÁbio Vila Nova, Tim Takken Tags: Original Article Source Type: research
Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke
Aim Wallerian degeneration is a radiological finding thought to reflect corticospinal tract degeneration. This finding on magnetic resonance imaging (MRI) is routinely used as a predictor of poor prognosis in childhood stroke. However, its validity has never been established. Our objective was to correlate Wallerian degeneration seen on MRI with histopathology.
Method We searched the databases of the Department of Pathology and Children’s Stroke registry at the Hospital for Sick Children, Toronto for autopsy specimens exhibiting focal infarcts from children born at term who underwent MRI after a stroke. The specime...
Source: Developmental Medicine and Child Neurology - November 22, 2012 Category: Child Development Authors: KEVIN C JONES, CYNTHIA HAWKINS, DEREK ARMSTRONG, GABRIELLE DEVEBER, DAUNE MACGREGOR, MAHENDRANATH MOHARIR, RAND ASKALAN Tags: ORIGINAL ARTICLE Source Type: research
