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Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke
Publication date: January 2016 Source:Prostaglandins & Other Lipid Mediators, Volume 122 Author(s): Hui Huang, Mohamed Al-Shabrawey, Mong-Heng Wang Arachidonic acid (AA) is metabolized by cyclooxygenase (COX) and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in cardiovascular diseases and stroke. Evidence has demonstrated the important functions of these eicosanoids in regulating cerebral vascular tone, cerebral blood flow, and autoregulation of cerebral circulation. Although COX-2 inhibitors have been suggested as potential treatments for stroke, adverse events, including an increased ris...
Source: Prostaglandins and Other Lipid Mediators - January 11, 2016 Category: Lipidology Source Type: research

Effects of Angiotensin II Type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats
Conclusions: Our results indicate that candesartan protects against hypertension and adipocyte dysfunction in SHRSP. The induction of leptin expression appeared to be important factor in the inhibition of stroke lesions, whereas adiponectin was not a major regulator of blood pressure in SHRSP with genetic hypertension. Further studies are needed to elucidate the role of the renin--angiotensin system in adipose tissue dysfunction in relation to hypertensive end-organ damage.
Source: Lipids in Health and Disease - July 22, 2013 Category: Lipidology Authors: Kumiko TakemoriTakao InoueHiroyuki Ito Source Type: research

Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. Methods: Subjects with ischemic stroke of
Source: Lipids in Health and Disease - July 22, 2015 Category: Lipidology Authors: Liu LiuLixuan ZhanYisheng WangChengping BaiJianjun GuoQingyuan LinDonghai LiangEn Xu Source Type: research

Primary Prevention of Stroke is Strongly Correlated with Low-Density-Lipoprotein Cholesterol Reduction: A Meta-Regression Analysis
Statins have become the cornerstone of therapy for both primary and secondary prevention of cardiovascular (CV) and cerebrovascular diseases (CVD). Numerous studies and meta-analyses have documented these benefits independent of low-density-lipoprotein cholesterol (LDL-C) lowering. There are discrepant reports regarding the dependence of the stroke benefits on the baseline LDL-C levels. The relevance of LDL-C reduction from baseline in the era of pleiotropic benefits needs further exploration, especially, while comparing the primary stroke cohort with the secondary stroke prevention cohort.
Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Samit Ghosal, Krishna G Seshadri Tags: Lipid Management in Special Populations Source Type: research

Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4  years follow-up study
Studies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.
Source: Lipids in Health and Disease - January 8, 2019 Category: Lipidology Authors: Jia Zheng, Zhaoqing Sun, Xingang Zhang, Zhao Li, Xiaofan Guo, Yanxia Xie, Yingxian Sun and Liqiang Zheng Tags: Research Source Type: research

The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population
Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. T...
Source: Lipids in Health and Disease - October 12, 2020 Category: Lipidology Authors: Yan Mao, Lin Yang, Qian Chen, Guoqing Li, Yao Sun, Jiamin Wu, Zichao Xiong, Yuanwei Liu, Haiyue Li, Jianfeng Liu and Yong Zhang Tags: Research Source Type: research

Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case–control study
Background: The v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B gene (MAFB) has been associated with serum lipid levels in the Eurpean population, but little is known about such association in the Chinese population or in atherosclerosis-related patients. Therefore, the purpose of the present study was to assess the association of the single nucleotide polymorphisms (SNPs) in the MAFB and serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese population. Methods: A total of 1,065 unrelated patients (CAD, 525 and IS, 540) and 539 healthy controls were recruite...
Source: Lipids in Health and Disease - July 25, 2015 Category: Lipidology Authors: Qian YangRui-Xing YinYi-Jiang ZhouXiao-Li CaoTao GuoWu-Xian Chen Source Type: research

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial Patient-Oriented and Epidemiological Research
The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all ...
Source: The Journal of Lipid Research - December 31, 2016 Category: Lipidology Authors: Liu, Y., Kong, X., Wang, W., Fan, F., Zhang, Y., Zhao, M., Wang, Y., Wang, Y., Wang, Y., Qin, X., Tang, G., Wang, B., Xu, X., Hou, F. F., Gao, W., Sun, N., Li, J., Venners, S. A., Jiang, S., Huo, Y. Tags: Patient-Oriented and Epidemiological Research Source Type: research

The association of lipid metabolism relative gene polymorphisms and ischemic stroke in Han and Uighur population of Xinjiang
The present study is aimed to evaluate difference of lipid metabolism related gene single nucleotide polymorphisms (SNPs) with ischemic stroke (IS) in Han and Uighur population of Xinjiang, China.
Source: Lipids in Health and Disease - June 17, 2017 Category: Lipidology Authors: Yun-hua Yue, Ling-yun Liu, Liang Hu, You-mei Li, Jie-ping Mao, Xiao-ying Yang and Na-mu Dila Source Type: research

Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke
The present study was to detect the association of single nucleotide polymorphism (SNP) in the breast susceptibility gene 2 (BRCA2) and the risk of coronary artery disease (CAD) and ischemic stroke (IS).
Source: Lipids in Health and Disease - October 5, 2017 Category: Lipidology Authors: Liu Miao, Rui-Xing Yin, Shuo Yang, Feng Huang, Wu-Xian Chen and Xiao-Li Cao Tags: Research Source Type: research

Low LDL-C and risk of hemorrhagic stroke in Chinese adults
It is well-established that higher LDL and total cholesterol are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), that is, coronary heart disease (CHD) and ischemic stroke events, and that cholesterol-lowering by statins and other therapies reduce ASCVD risk. However, the picture is less clear for the 10% to 20% of strokes that are hemorrhagic rather than ischemic. A meta-analysis of observational studies shows that lower levels of LDL-C and total cholesterol are associated with higher risk of hemorrhagic strokes (HS), and with intracranial hemorrhage (ICH), a subset of HS.
Source: Journal of Clinical Lipidology - September 1, 2018 Category: Lipidology Authors: Rachel H. Mackey Tags: Editorial Source Type: research

Effects of fatty and lean fish intake on stroke risk: a meta-analysis of prospective cohort studies
Fish intake has been postulated to reduce the risk of stroke. However, whether the beneficial effect of fish are mainly linked to fat content, as a source of omega-3 polyunsaturated fatty acids, remains unclea...
Source: Lipids in Health and Disease - November 23, 2018 Category: Lipidology Authors: Zhi-Zhen Qin, Jia-Ying Xu, Guo-Chong Chen, Yu-Xia Ma and Li-Qiang Qin Tags: Research Source Type: research

Sex difference in the incidence of stroke and its corresponding influence factors: results from a follow-up 8.4 years of rural China hypertensive prospective cohort study
Few studies investigate sex difference in stroke incidence in rural China hypertensive population.
Source: Lipids in Health and Disease - March 25, 2019 Category: Lipidology Authors: Yali Wang, Yue Dai, Jia Zheng, Yanxia Xie, Rongrong Guo, Xiaofan Guo, Guozhe Sun, Zhaoqing Sun, Yingxian Sun and Liqiang Zheng Tags: Research Source Type: research

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke
Genome-wide association study (GWAS) identified chromosome 12p13 rs12425791 and rs11833579 as susceptibility loci of ischemic stroke (IS) in a European population. However, conflicting results were obtained in...
Source: Lipids in Health and Disease - May 10, 2019 Category: Lipidology Authors: Zhi-Neng Zeng, Ling-Ling Liu, Yong-Ling He, Xiang Shi and Ye-Sheng Wei Tags: Research Source Type: research

Association of sleep duration with stroke, myocardial infarction, and tumors in a Chinese population with metabolic syndrome: a retrospective study
Previous studies have suggested that abnormal sleep duration is associated with increased risk of metabolic syndrome (MetS). However, evidence on the association of sleep duration with stroke, myocardial infar...
Source: Lipids in Health and Disease - June 27, 2020 Category: Lipidology Authors: Yingnan YE, Linxi ZHANG, Anping WANG, Yuxia Wang, Shiqing WANG, Guang NING and Yiming MU Tags: Research Source Type: research

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