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Total 4983 results found since Jan 2013.

Relative Influence of Capillary Index Score, Revascularization, and Time on Stroke Outcomes From the Interventional Management of Stroke III Trial Clinical Sciences
Conclusions— In this subset of patients from the Interventional Management of Stroke III Trial, CIS and modified thrombolysis in cerebral infarction were strong predictors of outcome after endovascular reperfusion. Using the CIS to improve patient selection could be a powerful strategy to improve rate of good outcomes in endovascular therapy. A randomized trial is needed. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00359424.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Al-Ali, F., Elias, J. J., Tomsick, T. A., Liebeskind, D. S., Broderick, J. P., on behalf of the IMS Study Groups Tags: Acute Cerebral Infarction, Emergency treatment of Stroke Clinical Sciences Source Type: research

Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic Stroke Clinical Sciences
Conclusions— Desmoteplase in both 70 and 90 μg/kg doses had a favorable safety profile and was well tolerated in Japanese patients with acute ischemic stroke when administered 3 to 9 hours after stroke symptoms onset. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01104467.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Mori, E., Minematsu, K., Nakagawara, J., Hasegawa, Y., Nagahiro, S., Okada, Y., Truelsen, T., Lindsten, A., Ogawa, A., Yamaguchi, T., on behalf of DIAS-J Investigators Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Thrombolysis Clinical Sciences Source Type: research

Quantitative Arterial Tortuosity Suggests Arteriopathy in Children With Cryptogenic Stroke Brief Report
Conclusions—Pediatric cryptogenic stroke is frequently associated with cervicocerebral arteriopathies expressing altered QAT. QAT may be a diagnostic biomarker of arteriopathy in pediatric AIS.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Gabriel DeVela, J. Michael Taylor, Bin Zhang, Luke L. Linscott, Alan M. Chen, Kunal B. Karani, Andrew Furthmiller, James L. Leach, Sudhakar Vadivelu, Todd Abruzzo Tags: Vascular Biology, Pediatrics, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Carotid-Bulb Atypical Fibromuscular Dysplasia in Young Afro-Caribbean Patients With Stroke Brief Reports
Conclusions— CaFMD could be a common condition in young Afro-Caribbeans with carotid-territory ischemic stroke. Recurrences were frequent under antiplatelet treatment, while surgical CaFMD removal seemed more effective.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Joux, J., Chausson, N., Jeannin, S., Saint-Vil, M., Mejdoubi, M., Hennequin, J.-L., Deschamps, L., Smadja, D., Olindo, S. Tags: Carotid Stenosis, Pathology of Stroke, Epidemiology Brief Reports Source Type: research

Influence of Arterial Occlusion on Outcome After Intravenous Thrombolysis for Acute Ischemic Stroke Clinical Sciences
Conclusions— In this retrospective analysis of consecutive patients with acute ischemic stroke, there was a trend for more favorable outcomes with IVT in the setting of initial arterial occlusion than in the setting of no/minimal obstruction. Before confirmation in randomized controlled studies, this information should not influence thrombolysis decisions, however.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Medlin, F., Amiguet, M., Vanacker, P., Michel, P. Tags: Arterial thrombosis, CT and MRI, Acute Cerebral Infarction, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Time-Resolved C-Arm Computed Tomographic Angiography Derived From Computed Tomographic Perfusion Acquisition: New Capability for One-Stop-Shop Acute Ischemic Stroke Treatment in the Angiosuite Clinical Sciences
Conclusions— Time-resolved CTAs derived from C-arm CT perfusion acquisitions provide high quality images that allowed accurate diagnosis of large vessel occlusions. Although image quality of smaller arteries in this study was not optimal ongoing modifications of the postprocessing algorithm will likely remove this limitation. Adding time-resolved C-arm CTAs to the capabilities of the angiography suite further enhances its suitability as a one-stop shop for care for patients with acute ischemic stroke.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Yang, P., Niu, K., Wu, Y., Struffert, T., Dorfler, A., Schafer, S., Royalty, K., Strother, C., Chen, G.-H. Tags: Angiography, Diagnostic Testing, Imaging, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Dynamic Magnetic Resonance Angiography Provides Collateral Circulation and Hemodynamic Information in Acute Ischemic Stroke Brief Reports
Conclusions— As a fast, direct, feasible, noninvasive, and reliable method to assess site of occlusion, collateral circulation and hemodynamic alterations, dMRA provides profound insights in acute stroke.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Hernandez-Perez, M., Puig, J., Blasco, G., Perez de la Ossa, N., Dorado, L., Davalos, A., Munuera, J. Tags: Imaging, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Influence of Device Choice on the Effect of Intra-Arterial Treatment for Acute Ischemic Stroke in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Clinical Sciences
Conclusions— We found no evidence for a differential effect of thrombectomy for acute ischemic stroke by type of stent. Clinical Trial Registration— URL: http://www.isrctn.com. Unique identifier: ISRCTN10888758.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Dippel, D. W., Majoie, C. B., Roos, Y. B., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Lingsma, H. F., Koudstaal, P. J., Treurniet, K. M., van den Berg, L. A., Beumer, D., Fransen, P. S., Berkhemer, O. A., for the MR CLEAN Investigators Tags: Ischemic Stroke Clinical Sciences Source Type: research

Anesthesia-Related Outcomes for Endovascular Stroke Revascularization Clinical Sciences
Conclusions—Acute ischemic stroke patients undergoing intra-arterial therapy may have worse outcomes when treated with GA as compared with conscious sedation/local anesthesia. However, major limitations of current evidence (ie, retrospective studies and selection bias) indicate a need for adequately powered, multicenter randomized controlled trials to answer this question.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Waleed Brinjikji, Jeffrey Pasternak, Mohammad H. Murad, Harry J. Cloft, Tasha L. Welch, David F. Kallmes, Alejandro A. Rabinstein Tags: Revascularization, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

CLOTBUST-Hands Free: Pilot Safety Study of a Novel Operator-Independent Ultrasound Device in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Sonothrombolysis using a novel, operator-independent device, in combination with systemic tPA, seems safe, and recanalization rates warrant evaluation in a phase III efficacy trial. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: CLOTBUST-HF NCT01240356.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Barreto, A. D., Alexandrov, A. V., Shen, L., Sisson, A., Bursaw, A. W., Sahota, P., Peng, H., Ardjomand-Hessabi, M., Pandurengan, R., Rahbar, M. H., Barlinn, K., Indupuru, H., Gonzales, N. R., Savitz, S. I., Grotta, J. C. Tags: Acute Cerebral Infarction, Doppler ultrasound, Transcranial Doppler etc., Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy Clinical Sciences
Conclusions— The MRA–DWI mismatch is a promising alternative to DEFUSE 2’s PWI–DWI mismatch for patient selection in endovascular stroke trials.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Mishra, N. K., Albers, G. W., Christensen, S., Marks, M., Hamilton, S., Straka, M., Liggins, J. T. P., Kemp, S., Mlynash, M., Bammer, R., Lansberg, M. G., for Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Investigators Tags: Angiography, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Influence of Age on Clinical and Revascularization Outcomes in the North American Solitaire Stent-Retriever Acute Stroke Registry Clinical Sciences
Conclusion— Greater than 80 years of age is predictive of poor clinical outcome and increased mortality compared with younger patients in the NASA registry. However, intravenous tissue-type plasminogen activator use, lower NIHSS, and shorter revascularization time are associated with better outcomes. Further studies are needed to understand the endovascular therapy role in this cohort compared with medical therapy.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Castonguay, A. C., Zaidat, O. O., Novakovic, R., Nguyen, T. N., Taqi, M. A., Gupta, R., Sun, C.-H. J., Martin, C., Holloway, W. E., Mueller-Kronast, N., E. English, J., Linfante, I., Dabus, G., Malisch, T. W., Marden, F. A., Bozorgchami, H., Xavier, A., R Tags: Acute Cerebral Infarction, Emergency treatment of Stroke Clinical Sciences Source Type: research

Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Thrombus perviousness, as measured on computed tomography in the acute stage of ischemic stroke, is strongly associated with recanalization after intravenous r-tPA treatment and with favorable functional outcome.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Santos, E. M. M., Dankbaar, J. W., Treurniet, K. M., Horsch, A. D., Roos, Y. B., Kappelle, L. J., Niessen, W. J., Majoie, C. B., Velthuis, B., Marquering, H. A., on behalf of the DUST Investigators, Duijm, Keizer, van der Lugt, Dippel, Droogh - de Greeve, Tags: Computerized Tomography (CT), Prognosis, Revascularization, Treatment, Ischemic Stroke Clinical Sciences Source Type: research

Power of an Adaptive Trial Design for Endovascular Stroke Studies Clinical Sciences
Conclusions—These simulations, based on real-world patient data, indicate that adaptive subgroup selection has merit in endovascular stroke trials as it substantially increases power when the treatment effect differs among subgroups in a predicted pattern.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Maarten G. Lansberg, Ninad S. Bhat, Sharon D. Yeatts, Yuko Y. Palesch, Joseph P. Broderick, Gregory W. Albers, Tze L. Lai, Philip W. Lavori Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke Clinical Sciences
Background and Purpose—Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction.Methods—Patients with M1-middle cerebral artery occlusions were prospectively included in this multicenter study. Regional analysis was performed for each patient within Alberta Stroke Program Early CT Score regions M2 to M6. Regional pial vessel filling was assessed on mCTA in 3 ways: (1) Washout of contrast within pial vessels; (2) Extent of maximal pial vessel enhancement compared with contralateral ...
Source: Stroke - March 27, 2017 Category: Neurology Authors: Christopher D. d’Esterre, Anurag Trivedi, Pooneh Pordeli, Mari Boesen, Shivanand Patil, Seong Hwan Ahn, Mohamed Naȷm, Enrico Fainardi, Jai Jai Shiva Shankar, Marta Rubiera, Mohammed A. Almekhlafi, Jennifer Mandzia, Alexander V. Khaw, Philip Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research