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Total 290 results found since Jan 2013.

The Role of Ferroptosis in Nervous System Disorders
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.ABSTRACTFerroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain in...
Source: Journal of Integrative Neuroscience - February 1, 2023 Category: Neuroscience Authors: Lixia Du You Wu Zhongmin Fan Yi Li Xiaofeng Guo Zongping Fang Xijing Zhang Source Type: research

Emerging role of miRNAs in the regulation of ferroptosis
Front Mol Biosci. 2023 Feb 15;10:1115996. doi: 10.3389/fmolb.2023.1115996. eCollection 2023.ABSTRACTFerroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis. The im...
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Reza Mahmoudi-Lamouki Sepideh Kadkhoda Bashdar Mahmud Hussen Soudeh Ghafouri-Fard Source Type: research

The Role of Ferroptosis in Nervous System Disorders
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.ABSTRACTFerroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain in...
Source: Journal of Integrative Neuroscience - February 1, 2023 Category: Neuroscience Authors: Lixia Du You Wu Zhongmin Fan Yi Li Xiaofeng Guo Zongping Fang Xijing Zhang Source Type: research