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The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis
Int J Mol Sci. 2021 Dec 15;22(24):13477. doi: 10.3390/ijms222413477.ABSTRACTL-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warrant further investigation. Here we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice. GPC can be metabolized to trimethylamine N-oxide, a pro-atherogenic agent, suggesting a potential molecular mechanism underlying the observed atherosclerosis progression. GPC supplementation shifted t...
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Zeneng Wang Jennie Hazen Xun Jia Elin Org Yongzhong Zhao Lucas J Osborn Nisreen Nimer Jennifer Buffa Miranda K Culley Daniel Krajcik Bert-Jan H van den Born Koos Zwinderman Bruce S Levison Max Nieuwdorp Aldons J Lusis Joseph A DiDonato Stanley L Hazen Source Type: research

Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack Stroke
Conclusions Participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Yin, J., Liao, S.-X., He, Y., Wang, S., Xia, G.-H., Liu, F.-T., Zhu, J.-J., You, C., Chen, Q., Zhou, L., Pan, S.-Y., Zhou, H.-W. Tags: Stroke Source Type: research