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Specialty: Neurology
Source: Stroke
Education: Study
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Total 1821 results found since Jan 2013.
Real-World Setting Comparison of Nonvitamin-K Antagonist Oral Anticoagulants Versus Vitamin-K Antagonists for Stroke Prevention in Atrial Fibrillation Clinical Sciences
Conclusions—This meta-analysis confirms the main findings of the randomized controlled trials of dabigatran, rivaroxaban, and apixaban in the real-world setting and, hence, strengthens their validity.
Source: Stroke - August 28, 2017 Category: Neurology Authors: George Ntaios, Vasileios Papavasileiou, Konstantinos Makaritsis, Konstantinos Vemmos, Patrik Michel, Gregory Y.H. Lip Tags: Arrhythmias, Secondary Prevention, Meta Analysis, Mortality/Survival, Ischemic Stroke Original Contributions Source Type: research
Factors Associated With Time to Site Activation, Randomization, and Enrollment Performance in a Stroke Prevention Trial Clinical Sciences
Conclusions—Overall, selection of sites with high enrollment rates will likely require customization to align the sites selected to the factor under study in the trial.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02089217.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Bart M. Demaerschalk, Robert D. Brown Jr, Gary S. Roubin, Virginia J. Howard, Eldina Cesko, Kevin M. Barrett, Mary E. Longbottom, Jenifer H. Voeks, Seemant Chaturvedi, Thomas G. Brott, Brajesh K. Lal, James F. Meschia, George Howard Tags: Stent, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research
Systematic Review of the Cost and Cost-Effectiveness of Rapid Endovascular Therapy for Acute Ischemic Stroke Clinical Sciences
The objective of this study was to establish the cost-effectiveness of EVT for ischemic stroke patients and to synthesize all the publicly available economic literature.Methods—A systematic review of the published literature was conducted to identify economic evaluations and cost analyses of EVT for acute ischemic stroke patients. Systematic review best practices were followed, and study quality was assessed.Results—Four-hundred sixty-three articles were identified from electronic databases. After deduplication, abstract review, and full-text review, 17 studies were included. Seven of the studies were cost analyses, an...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Laura K. Sevick, Sarah Ghali, Michael D. Hill, Vishva Danthurebandara, Diane L. Lorenzetti, Tom Noseworthy, Eldon Spackman, Fiona Clement Tags: Treatment, Ischemic Stroke Original Contributions Source Type: research
Impact of Stroke Center Certification on Mortality After Ischemic Stroke Clinical Sciences
This study aimed to understand whether PSC certification reduced stroke mortality.Methods—We examined Medicare fee-for-service beneficiaries aged ≥65 years who were hospitalized between 2009 and 2013 for ischemic stroke. Hospitals were classified into 3 groups: new PSCs, the hospitals that received initial PSC certification between 2009 and 2013 (n=634); existing PSCs, the PSCs certified before 2009 (n=785); and non-SCs, the hospitals that have never been certified as PSCs (n=2640). Multivariate logistic regression and Cox proportional hazards model was used to compare the mortality among the 3 groups.Results—Existin...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Shumei Man, Jesse D. Schold, Ken Uchino Tags: Health Services, Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Palliative Care for Hospitalized Patients With Stroke Clinical Sciences
This study explores patterns of palliative care utilization and death in hospitalized patients with stroke across the United States.Methods—Using the 2010 to 2012 nationwide inpatient sample databases, we included all patients discharged with stroke identified by International Classification of Diseases-Ninth Revision codes. Strokes were subclassified as ischemic, intracerebral, and subarachnoid hemorrhage. We compared demographics, comorbidities, procedures, and outcomes between patients with and without a palliative care encounter (PCE) as defined by the International Classification of Diseases-Ninth Revision code V66....
Source: Stroke - August 28, 2017 Category: Neurology Authors: Tarvinder Singh, Steven R. Peters, David L. Tirschwell, Claire J. Creutzfeldt Tags: Race and Ethnicity, Quality and Outcomes, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia Basic Sciences
Conclusions—This is a first study that shows that stroke alters the expression of circRNAs with possible functional implication to poststroke pathophysiology.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Suresh L. Mehta, Gopal Pandi, Raghu Vemuganti Tags: Basic Science Research, Ischemic Stroke Original Contributions Source Type: research
Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice Basic Sciences
Conclusions—The data show that the kinase domain of RIPK1 is a disease driver of ICH, mediating both acute cell death and functional outcome, and support development of RIPK1 inhibitors as therapeutic agents for human ICH.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Sevda Lule, Limin Wu, Lauren M. McAllister, William J. Edmiston III, Joon Yong Chung, Emily Levy, Yi Zheng, Peter J. Gough, John Bertin, Alexei Degterev, Eng H. Lo, Michael J. Whalen Tags: Basic Science Research, Genetically Altered and Transgenic Models, Intracranial Hemorrhage Original Contributions Source Type: research
Brain Transforming Growth Factor-{beta} Resists Hypertension Via Regulating Microglial Activation Basic Sciences
Conclusions—Our results identify that TGF-β–modulated microglia are critical to keeping brain homeostasis responding to hypertensive disturbance.
Source: Stroke - August 28, 2017 Category: Neurology Authors: You Li, Xiao Z. Shen, Liang Li, Tuantuan V. Zhao, Kenneth E. Bernstein, Alan K. Johnson, Patrick Lyden, Jianmin Fang, Peng Shi Tags: Hypertension Original Contributions Source Type: research
Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice Basic Sciences
Conclusions—Clock gene expression regulates, in part, the severity of SAH and requires myeloid HO-1 activity to clear the erythrocyte burden and inhibit neuronal apoptosis. Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Nils Schallner, Judith-Lisa Lieberum, David Gallo, Robert H. LeBlanc III, Patrick M. Fuller, Khalid A. Hanafy, Leo E. Otterbein Tags: Inflammation, Translational Studies, Intracranial Hemorrhage Original Contributions Source Type: research
Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation Basic Sciences
Conclusions—Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of IAs. Thus, tPA should be considered as a possible new target for the prevention of IAs formation and rupture.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Paul–Emile Labeyrie, Romain Goulay, Sara Martinez de Lizarrondo, Marie Hebert, Maxime Gauberti, Eric Maubert, Barbara Delaunay, Benȷamin Gory, Francesco Signorelli, Francis Turȷman, Emmanuel Touze, Patrick Courtheoux, Denis Vivien, Cyr Tags: Animal Models of Human Disease, Pathophysiology, Cerebral Aneurysm Original Contributions Source Type: research
Early Dysphagia Screening by Trained Nurses Reduces Pneumonia Rate in Stroke Patients Brief Report
Conclusions—24/7 dysphagia screening can be effectively performed by nurses and leads to reduced pneumonia rates. Therefore, empowering nurses to do a formal bedside screening for swallowing dysfunction in stroke patients timely after admission is warranted whenever speech–language therapists are not available.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Christoph Palli, Simon Fandler, Kathrin Doppelhofer, Kurt Niederkorn, Christian Enzinger, Christian Vetta, Esther Trampusch, Reinhold Schmidt, Franz Fazekas, Thomas Gattringer Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research
Plasma Glial Fibrillary Acidic Protein in the Differential Diagnosis of Intracerebral Hemorrhage Brief Report
Background and Purpose—Plasma GFAP (glial fibrillary acidic protein) has recently emerged as a potential biomarker for the differentiation of acute intracerebral hemorrhage (ICH) from acute ischemic stroke (AIS). We prospectively assessed the diagnostic accuracy of GFAP in the differential diagnosis of ICH.Methods—Consecutive patients presenting to the emergency department within 6 hours from symptom onset were evaluated. All patients underwent extensive diagnostic work-up and were classified according to discharge diagnosis in AIS, ICH, subarachnoid hemorrhage, and stroke mimics. GFAP was also measured in healthy volu...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Aristeidis H. Katsanos, Konstantinos Makris, Dimitra Stefani, Katerina Koniari, Eleni Gialouri, Moses Lelekis, Maria Chondrogianni, Christina Zompola, Efthymios Dardiotis, Ioannis Rizos, John Parissis, Eleni Boutati, Konstantinos Voumvourakis, Georgios Ts Tags: Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research
Neutrophil-Lymphocyte Ratio and Perihematomal Edema Growth in Intracerebral Hemorrhage Brief Report
Conclusions—Higher neutrophil–lymphocyte ratio is independently associated with PHE growth. This suggests that PHE growth can be predicted using differential leukocyte counts on admission.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Aaron M. Gusdon, Gino Gialdini, Gbambele Kone, Hediyeh Baradaran, Alexander E. Merkler, Halinder S. Mangat, Babak B. Navi, Costantino Iadecola, Ajay Gupta, Hooman Kamel, Santosh B. Murthy Tags: Intracranial Hemorrhage Brief Reports Source Type: research
Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research
Early Imaging Prediction of Malignant Cerebellar Edema Development in Acute Ischemic Stroke Brief Report
Background and Purpose—Malignant cerebellar edema (MCE) is a life-threatening complication of acute ischemic stroke that requires timely diagnosis and management. Aim of this study was to identify imaging predictors in initial multiparametric computed tomography (CT), including whole-brain CT perfusion (WB-CTP).Methods—We consecutively selected all subjects with cerebellar ischemic WB-CTP deficits and follow-up–confirmed cerebellar infarction from an initial cohort of 2635 patients who had undergone multiparametric CT because of suspected stroke. Follow-up imaging was assessed for the presence of MCE, measured using ...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Matthias P. Fabritius, Kolja M. Thierfelder, Felix G. Meinel, Ahmed E. Othman, Franziska Dorn, Bastian O. Sabel, Pierre Scheffler, Birgit Ertl-Wagner, Wieland H. Sommer, Wolfgang G. Kunz Tags: Computerized Tomography (CT), Prognosis, Complications, Mortality/Survival, Ischemic Stroke Brief Reports Source Type: research
