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Source: Brain Research
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Total 351 results found since Jan 2013.
The relationship between the prefrontal cortex and limb motor function in stroke: A study based on resting-state functional near-infrared spectroscopy
CONCLUSION: These study results showed that stroke can cause cerebral haemodynamic changes in the PFC, and the functional imbalance of the left and right PFC in the resting state is correlated with the severity of limb motor dysfunction. Furthermore, we emphasize that the cerebral haemodynamic activity reflected by fNIRS could be used as a reliable neural biomarker for assessing limb motor dysfunction in stroke.PMID:36736871 | DOI:10.1016/j.brainres.2023.148269
Source: Brain Research - February 3, 2023 Category: Neurology Authors: Dan Wang Jie Wang Hongbo Zhao Yahui Liang Wenyue Zhang Mingxi Li Hua Liu Di Hu Sibin Zhang Enlong Xing Ying Su Wanchen Yu Jinyan Sun Aoran Yang Source Type: research
Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis
Exp Brain Res. 2023 Feb 3. doi: 10.1007/s00221-023-06555-3. Online ahead of print.ABSTRACTThe pivotal regulatory role of circular RNAs (circRNAs) in ischemic stroke (IS) has been expounded. The study aimed to probe the exact role and underlying mechanism of circVRK1 in oxygen-glucose deprivation (OGD)-induced human brain microvascular endothelial cells (HBMECs) injury. HBMECs challenged by OGD were used as in vitro models of IS. Quantitative real-time PCR was used to examine the levels of circVRK1, vaccinia-related kinase 1 (VRK1), miR-150-5p and MLLT1 mRNA. Cell viability, migration angiogenesis ability and death were eva...
Source: Brain Research - February 3, 2023 Category: Neurology Authors: Lina Tan Lingjun Wang Jiajun Liu Yue Yu Source Type: research
Tongqiao Huoxue decoction alleviates neurological impairment following ischemic stroke via the PTGS2/NF-kappa B axis
Brain Res. 2023 Jan 17:148247. doi: 10.1016/j.brainres.2023.148247. Online ahead of print.ABSTRACTTraditional Chinese medicine has emerged as promising targets for ischemic stroke (IS) therapy, yet the mechanism remains elusive. The current study was performed with an aim to investigate the action and mechanism of Tongqiao Huoxue decoction (TQHXD) affecting the neurological impairment secondary to IS based on network pharmacology. Based on network pharmacology and bioinformatics analysis, target genes and pathways involved in the treatment of TQHXD against IS were predicted. Serum containing TQHXD was prepared through bloo...
Source: Brain Research - January 20, 2023 Category: Neurology Authors: Zheyi Zhou Linglu Dun Qian Yang Jingrui Tao Peishan Yu Hong Xu Na Zhao Na Zheng Hongwei An Ping Yi Source Type: research
Neuroprotective Effects of Pre-Ischemic Exercise are linked to Expression of NT-3/NT-4 and TrkB/TrkC in Rats
CONCLUSION: The findings showed that pre-ischemic exercise can exert neuroprotective effectsvia NT-3 and NT-4 pathways against ischemia in hippocampal CA1 neurons and promote post-injury sensorimotor recovery.PMID:36646145 | DOI:10.1016/j.brainresbull.2023.01.004
Source: Brain Research - January 16, 2023 Category: Neurology Authors: AbdorrezaEghbal Moghanlou Mohtaram Yazdanian Sajad Roshani Abdullah Demirli Mehdi Seydyousefi Gerlinde A S Metz Zeinab Faghfoori Source Type: research
Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Brain Research - January 7, 2023 Category: Neurology Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research
TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3 β signaling pathway
In conclusion, Fer-1 has protective effects on cerebral I/R injury by activating the AKT/GSK3β pathway, indicating that ferroptosis may become a novel target in the treatment of ischemic stroke.PMID:36596364 | DOI:10.1016/j.brainresbull.2022.12.009
Source: Brain Research - January 3, 2023 Category: Neurology Authors: Xinyao Liu Yue Du Jian Liu Linggang Cheng Wen He Wei Zhang Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage
CONCLUSION: BHB can improve the cognitive impairment caused by CCH. The potential mechanisms of BHB may be through reducing neuroinflammation and protecting BBB.PMID:36577190 | DOI:10.1016/j.brainresbull.2022.12.011
Source: Brain Research - December 28, 2022 Category: Neurology Authors: Zhitian Wang Tian Li Miaoyu Du Lei Zhang Linling Xu Hao Song Junjian Zhang Source Type: research
