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Total 838 results found since Jan 2013.

Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients
Conclusions: The ICAM-1 (G1548A) polymorphism was associated with independent risk factor for the development of IS.
Source: Annals of Indian Academy of Neurology - August 26, 2013 Category: Neurology Authors: Ching-Hsiang LuChiao-Wen HwangNan-Fu ChenWen-Sheng LiuWen-Tung Wu Source Type: research

Optogenetic stimulation for stroke recovery Neuroscience
Clinical and research efforts have focused on promoting functional recovery after stroke. Brain stimulation strategies are particularly promising because they allow direct manipulation of the target area’s excitability. However, elucidating the cell type and mechanisms mediating recovery has been difficult because existing stimulation techniques nonspecifically target all cell types near...
Source: Proceedings of the National Academy of Sciences - September 2, 2014 Category: Science Authors: Cheng, M. Y., Wang, E. H., Woodson, W. J., Wang, S., Sun, G., Lee, A. G., Arac, A., Fenno, L. E., Deisseroth, K., Steinberg, G. K. Tags: Biological Sciences Source Type: research

Treatment of Post‐Stroke Spasticity
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Source: World Stroke Academy - June 20, 2014 Category: Neurology Authors: Michael Brainin Tags: Editorial Source Type: research

Influence of trial design, heterogeneity and regulatory environment on the results of clinical trials: An appraisal in the context of recent trials on acute stroke intervention
PR Srijithesh, Shakir HusainAnnals of Indian Academy of Neurology 2014 17(4):365-370The outcome of randomized controlled trials can vary depending on the eligibility criteria of the patients entering into the trial, as well as the heterogeneity of the eligible population and/or the interventions. If the subject population and/or interventions are heterogeneous, the final outcome of the trial depends on the degree of concordance of effects of the subgroups of interventions on the subgroups of the subject population. The considerations that go into the calculation of sample size and determination of the study stopping rules ...
Source: Annals of Indian Academy of Neurology - November 5, 2014 Category: Neurology Authors: PR SrijitheshShakir Husain Source Type: research

Development of the Trevo ProVue Retriever for intracranial clot removal in acute ischemic stroke
It is estimated that 15 million people worldwide have a stroke each year. Of the estimated 795,000 strokes that occur in the United States annually, the majority are ischemic strokes resulting from an obstruction within a vessel supplying blood to the brain. The treatment goal for these patients is to restore blood flow as quickly as possible. Increasingly, endovascular treatments that interact directly with the clot are being pursued as options. Receiving U.S. Food and Drug Administration clearance in 2012, the Trevo® Retriever is a stent‐like structure to be deployed at the site of an occlusion to allow the occluding ...
Source: Annals of the New York Academy of Sciences - November 14, 2014 Category: Science Authors: Heather C. Prince, Amelia J. Saliba, Jaime Wheeler, Scott Bruder Tags: Original Article Source Type: research

Immune modulation in acute ischemic stroke Medical Sciences
Peripheral lymphocytes entering brain ischemic regions orchestrate inflammatory responses, catalyze tissue death, and worsen clinical outcomes of acute ischemic stroke (AIS) in preclinical studies. However, it is not known whether modulating brain inflammation can impact the outcome of patients with AIS. In this open-label, evaluator-blinded, parallel-group clinical pilot trial, we...
Source: Proceedings of the National Academy of Sciences - December 23, 2014 Category: Science Authors: Fu, Y., Zhang, N., Ren, L., Yan, Y., Sun, N., Li, Y.-J., Han, W., Xue, R., Liu, Q., Hao, J., Yu, C., Shi, F.-D. Tags: Biological Sciences Source Type: research

SRF/MRTF depletion provokes hemorrhagic stroke Cell Biology
Intracerebral hemorrhagic stroke and vascular dementia are age- and hypertension-associated manifestations of human cerebral small vessel disease (SVD). Cerebral microvessels are formed by endothelial cells (ECs), which are connected through tight junctions, adherens junctions, and stabilizing basement membrane structures. These endothelial connections ensure both vessel stability and blood–brain barrier (BBB)...
Source: Proceedings of the National Academy of Sciences - August 11, 2015 Category: Science Authors: Weinl, C., Castaneda Vega, S., Riehle, H., Stritt, C., Calaminus, C., Wolburg, H., Mauel, S., Breithaupt, A., Gruber, A. D., Wasylyk, B., Olson, E. N., Adams, R. H., Pichler, B. J., Nordheim, A. Tags: Biological Sciences Source Type: research

Underutilisation of Guideline-based Therapy Primary Prevention among Patients Presenting with AF-related Ischaemic Stroke.
PMID: 26377061 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - July 1, 2015 Category: Journals (General) Authors: Fabiaña N, Ramaswami AP, Ang ES Tags: Ann Acad Med Singapore Source Type: research

Homogeneity and the outcome of clinical trials: An appraisal of the outcome of recent clinical trials on endovascular intervention in acute ischemic stroke
Shakir Husain, PR SrijitheshAnnals of Indian Academy of Neurology 2016 19(1):21-24Clinical trials that allow significant heterogeneity of population or interventions often result in uncertain outcomes. In this paper, we review the outcomes of five recent trials of endovascular interventions in acute ischemic stroke in the context of the neutral results of previous large clinical trials on the subject.
Source: Annals of Indian Academy of Neurology - February 2, 2016 Category: Neurology Authors: Shakir HusainPR Srijithesh Source Type: research

Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study
Conclusion: Serum Hcy levels correlate well with CIMT and hence may predict atherothrombotic events.
Source: Annals of Indian Academy of Neurology - February 2, 2016 Category: Neurology Authors: Anup J DevasiaBinu JoySubhash D Tarey Source Type: research

Training Guidelines for Endovascular Ischemic Stroke Intervention: An International multi-society consensus document.
Authors: Abstract ContributorsAmerican Academy of Neurological Surgeons/ Congress of Neurological Surgeons (AANS/CNS): S.D. Lavine, K Cockroft, B Hoh, N Bambakidis, AA Khalessi, H Woo, H Riina. A. SiddiquiAmerican Society of Neuroradiology (ASNR): J. A. HirschAsian Australasian Federation of Interventional and Therapeutic Neuroradiology (AAFITN): W. ChongAustralian and New Zealand Society of Neuroradiology - Conjoint Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR), ANZAN and NSA: H. Rice, J Wenderoth, P Mitchell, A Coulthard, TJ Signh, C Phatorous, M ...
Source: Interventional Neuroradiology - March 11, 2016 Category: Radiology Tags: Interv Neuroradiol Source Type: research

”Missing clot” during mechanical thrombectomy in acute stroke using Solitaire stent retrieval system
Vikram Huded, Vivek Nambiar, Romnesh De Souza, Vikram Bohra, Ritesh RamankuttyAnnals of Indian Academy of Neurology 2016 19(2):279-280Stent retrieval system is an established treatment modality in acute ischemic stroke with large vessel occlusion. Here, we describe a complication which occurred during mechanical thrombectomy in three cases where the clot dislodged during retrieval. There was a possibility of the clot getting reinjected into the artery with possible dire consequences.
Source: Annals of Indian Academy of Neurology - May 11, 2016 Category: Neurology Authors: Vikram HudedVivek NambiarRomnesh De SouzaVikram BohraRitesh Ramankutty Source Type: research