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Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-inȷured rat brain regulates motor behavior Neuroscience
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
Source: Proceedings of the National Academy of Sciences - April 20, 2020 Category: Science Authors: Sara Palma–Tortosa, Daniel Tornero, Marita Gronning Hansen, Emanuela Monni, Mazin Haȷy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia Tags: Biological Sciences Source Type: research

Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation Neuroscience
Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential for regenerative medicine, given their feasibility for autologous transplantation. MSC research shows encouraging results in experimental stroke, amyotrophic lateral sclerosis, and neurotrauma models. However, further translational progress has been hampered by poor MSC graft survival, jeopardizing cellular and...
Source: Proceedings of the National Academy of Sciences - January 30, 2017 Category: Science Authors: Alexander E. Ropper, Devang K. Thakor, InBo Han, Dou Yu, Xiang Zeng, Jamie E. Anderson, Zaid Aljuboori, Soo-Woo Kim, Hongjun Wang, Richard L. Sidman, Ross D. Zafonte, Yang D. Teng Tags: PNAS Plus Source Type: research