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Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells
This study is complemented by another report that found that hRSV infection induces significant expression of three miRNAs, namely hsa-miR-4448, hsa-miR-30a-5p, and hsa-miR-4634 in human DCs (104). Interestingly, this latter study also performed comparative analyses of miRNA profiles between DCs infected with hRSV and a related virus, namely the human metapneumovirus, and found that both viruses induced the expression of elevated levels of hsa-miR-4634. Elucidating the contribution of these miRNAs in DCs in response to hRSV remains to be determined. Dendritic Cell Phenotype and Migration Upon hRSV Infection in vivo Altho...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

A Novel Regulator of Preadipocyte Differentiation, Transcription Factor TCF21, Functions Partially Through Promoting LPL Expression
Discussion Excessive fat deposition in chickens can result in many undesirable consequences within the poultry industry, including reduced feeding efficiency (Zhou et al., 2006) and decreased reproductive performance (Walzem and Chen, 2014). Thus, broiler breeders urgently require a more thorough understanding of the molecular mechanism governing chicken adipogenesis. We previously found that broilers from lean and fat lines exhibit clear differences in reproductive performance (Zhang et al., 2018). In addition, TCF21 was found to be related to testis growth and development in these broilers (Zhang et al., 2017). In mice ...
Source: Frontiers in Physiology - April 22, 2019 Category: Physiology Source Type: research

Analysis of the numbers of clinical trials on physical therapy in Japan: comparison with those in the North American register from 2010 to 2019
Conclusion] The proportion of CTPT is relatively low in Japan, compared with that in North America, and it showed no increasing trend. It is important to provide education and support for clinical trials in an aging country such as Japan.PMID:34219957 | PMC:PMC8245263 | DOI:10.1589/jpts.33.521
Source: Physical Therapy - July 5, 2021 Category: Physiotherapy Authors: Shunta Umeki Shinsuke Imaoka Kazuhiro Harada Kyouichi Ohashi Source Type: research

US recession saw more Google stress searches
Conclusion This research found that there were increased Google searches during the US "Great Recession" between December 2008 and 2011 for a range of health concerns, including headaches, stomach ulcers and other stomach problems, chest pain, heart rhythm problems and various other pains, including back pain and toothache. The researchers consider that this could potentially indicate worsening population health. However, although this is an interesting approach, it is limited by several factors. A person may search Google for information on a health complaint for many different reasons. It does not necessarily ...
Source: NHS News Feed - January 10, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Mental health Medical practice Source Type: news

HuR is Essential for TDP-43 Expression through Posttranscriptional Mechanisms: Implications for Motor Neuron Toxicity and ALS (1II-2.002)
Conclusions: 1. HuR is essential for proper expression of TDP-43. 2. HuR directly binds to TDP-43 mRNA and regulates its expression through the 3’ UTR. 3. Loss of HuR in astrocytes leads to the production of soluble factors that are toxic to cortical and motor neurons. These findings are consistent with our previous observations that impaired HuR function may contribute to ALS pathogenesis.Study supported by: Study supported by NIH/NINDS Grant NS057664.Disclosure: Dr. Lu has nothing to disclose. Dr. Zheng has nothing to disclose. Dr. Si has nothing to disclose. Dr. Oh has nothing to disclose. Dr. King has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lu, L., Zheng, L., Si, Y., Oh, S., King, P. Tags: Proteinopathy in Neurodegenerative Disease Data Blitz Presentations Source Type: research

HuR is Essential for TDP-43 Expression through Posttranscriptional Mechanisms: Implications for Motor Neuron Toxicity and ALS (S56.003)
Conclusions: 1. HuR is essential for proper expression of TDP-43. 2. HuR directly binds to TDP-43 mRNA and regulates its expression through the 3’ UTR. 3. Loss of HuR in astrocytes leads to the production of soluble factors that are toxic to cortical and motor neurons. These findings are consistent with our previous observations that impaired HuR function may contribute to ALS pathogenesis.Study supported by: Study supported by NIH/NINDS Grant NS057664.Disclosure: Dr. Lu has nothing to disclose. Dr. Zheng has nothing to disclose. Dr. Si has nothing to disclose. Dr. Oh has nothing to disclose. Dr. King has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lu, L., Zheng, L., Si, Y., Oh, S., King, P. Tags: Anterior Horn Disease Source Type: research

Abstract 861: Survivin-mediated adaptive response: a risk factor for IGRT
Exposure of cells to very low doses of ionizing radiation can induce an enhanced resistance or adaptive response to a subsequent larger radiation dose as demonstrated by an increase in cell survival. Expression of a radio-adaptive response has been attributed to pro-survival signaling processes induced by very low radiation doses in the range of 5 to 100 mGy. The radiation-induced adaptive response is gaining considerable attention due in part to the expanding use of imaging technologies such as computerized axial tomography and portal imaging to monitor tumor response and positioning during multi-dose standard radiation t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Grdina, D. J., Murley, J. S., Miller, R. C., Woloschak, G. E., Li, J. J., Weichselbaum, R. R. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Abstract 2332: Oncogenic mutant KRAS modulates EZH2 expression through MEK-ERK signaling by remodeling gene expression in NSCLC
In this study, we investigated whether pharmacological disruption of signaling MEK-ERK pathway would affect EZH2 expression in a panel of NSCLC cell lines with and without KRAS mutation. Moreover, we analyzed the transcriptome expression following knockdown of EZH2 expression in NSCLC cell lines with different types of KRAS mutations. Methods. NSCLC cell lines were treated with different doses of MEK inhibitor AZD6244 (0, 0.5 and 1μM) and the expressions of EZH2, MEK and MAPK were determined by Western-blots. Cell lines were transfected with gene-specific EZH2 siRNA and control siRNA. Gene expression profiling was perform...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Riquelme, E. M., Shen, L., Wang, J., Behrens, C., Minna, J. D., Wistuba, I. I. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2446: Signaling event of alcohol-induced deregulation of Pol III genes in breast cancer cells
We reported that alcohol induces Pol III gene (RNA polymerase III-dependent genes) transcription in vivo and in vitro. We continue to define novel and unexpected targets, MSK1 (mitogen- stress-activated protein kinase 1) and Brf1 (TFIIIB-related factor 1), in the alcohol-induced response. Our aim is to delineate the mechanisms regulating the processes of deregulation of Pol III genes, cell transformation and tumorgenesis through this alcohol-induced response. Brf1 specifically regulates Pol III gene transcription. Changes in Pol III gene and Brf1 expression tightly link to cell transformation and tumor formation. Alcohol-i...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Zhong, S., Zhang, Q., Shi, G. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3299: Maternal embryonic leucine zipper kinase is critical for the growth and migration of triple negative breast cancer cells
Conclusions: MELK is an important growth regulator of TNBC, but not of ER positive breast cancers. Our results indicate that MELK promotes cell migration in TNBC cells. These findings suggest that MELK is a promising target for the treatment of TNBC. Supported by a Susan G. Komen for the Cure Promise Grant (KG081694), and the John Charles Cain Award. Citation Format: Nidhi Batra, Corey Speers, Ivan Uray, Abhijit Mazumdar, Anna Tsimelzon, Susan Hilsenbeck, Gordon Mills, Powel Brown. Maternal embryonic leucine zipper kinase is critical for the growth and migration of triple negative breast cancer cells. [abstract]. In: Proce...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Batra, N., Speers, C., Uray, I., Mazumdar, A., Tsimelzon, A., Hilsenbeck, S., Mills, G., Brown, P. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4233: Mef2C enhances 1,25-dihydroxyvitamin D3-induced monocytic differentiation of human myeloid leukemia cells by regulating C/EBP{beta} expression
Myogenic enhancer factors 2 (Mef2) are members of the family of MADS (MCM1-agamous-deficiens-serum response factor)-box transcription factors known to have multiple roles in morphogenesis of skeletal, cardiac and smooth muscle cells. Recently, Mef2C was found to be also involved in hematopoiesis. Bone marrow cells isolated from Mef2C knockout mice demonstrated decreased monocytic differentiation in response to cytokine stimulation, whereas constitutive expression of Mef2C promoted monopoiesis. The above findings led us to examine the role of Mef2C in 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic differentiation. Human...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Zheng, R., Wang, X., Studzinski, G. P. Tags: Molecular and Cellular Biology Source Type: research

Abstract 813: Human papillomavirus 16 oncoprotein E6 upregulates c-Met partially through p53 in squamous cell carcinoma of the head and neck
Conclusion: Our results show that c-Met expression is upregulated by HPV E6, which is partially mediated by p53. The data suggest that targeting c-Met may serve as a novel approach for treating HPV-associated OPSCC.(This study was supported by grants from Small Business Innovation Research (SBIR) Program (HHSN261201200097C), National Institutes of Health (R33 CA161873), and National Cancer Institute (NCI P50 CA 128613, Head and Neck SPORE).Citation Format: Guoqing Qian, Dongsheng Wang, Kelly R. Magliocca, Praveen Duggal, Sreenivas Nannapaneni, Sungjin Kim, Zhengjia Chen, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen. Human pap...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Qian, G., Wang, D., Magliocca, K. R., Duggal, P., Nannapaneni, S., Kim, S., Chen, Z., Shin, D. M., Saba, N. F., Chen, Z. G. Tags: Carcinogenesis Source Type: research

Abstract 2081: The CCCTC-binding factor (CTCF) functions to downregulate the transcription of MGMT gene in human glioblastoma cells
The O6-methylguanine-DNA methyltransferase (MGMT) gene located at chromosome 10q26 encodes a DNA repair protein that abrogates the therapeutic effects of alkylating agents by preventing the formation of mutagenic lesions or cytotoxic DNA crosslinks. MGMT is highly expressed in human gliomas and its transcriptional regulation has emerged as a major translational focal point in neuro-oncology, because the epigenetic silencing of the MGMT gene which occurs in a subset of these malignancies confers improved treatment responses to both chemo and radiation therapies. While the promoter methylation and its contribution to glioma ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Srivenugopal, K. S., Al-Obaide, M. I. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2679: Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma
Melanoma harboring BRAF mutations frequently develop resistance to BRAF inhibitors, limiting the impact of treatment. The most prevalent mechanisms of acquired resistance appear to reactivate MAPK pathway. Furthermore, relatively little is known about the determinants of de novo resistance. Here, we establish such a mechanism of resistance and subsequently identified a suitable drug combination to overcome the resistance. Single treatment of BRAF mutant melanoma cell lines with vemurafenib or dabrafenib (BRAF inhibitors) alone or in combination with trametinib (MEK1/2 inhibitor) resulted in overexpression of Mcl-1. Overexp...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Fofaria, N. M., Frederick, D. T., Sullivan, R. J., Flaherty, K. T., Srivastava, S. K. Tags: Experimental and Molecular Therapeutics Source Type: research