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The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition
Discussion We have found that, in the human genome, the promoter regions of ID-associated genes are uniquely enriched in MER41 LTRs. More specifically, nine ID-associated genes that are putatively important in cognitive evolution exhibit MER41 LTRs in their promoter regions. As more than 100 families of HERV are integrated into our genome, it was important to determine whether our findings are specific to MER41 and to ID-associated genes, and if so to what extent. Among the 133 families of HERV explored here, MER41 is the only family whose LTRs were found with statistically high frequency in the promoter regions of ID-ass...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

More Coca-Cola Ties Seen Inside U.S. Centers For Disease Control
In June, Dr. Barbara Bowman, a high-ranking official within the Centers for Disease Control and Prevention, unexpectedly departed the agency, two days after information came to light indicating that she had been communicating regularly with - and offering guidance to - a leading Coca-Cola advocate seeking to influence world health authorities on sugar and beverage policy matters. Now, more emails suggest that another veteran CDC official has similarly close ties to the global soft drink giant. Michael Pratt, Senior Advisor for Global Health in the National Center for Chronic Disease Prevention and Health Promotion at the...
Source: Science - The Huffington Post - August 1, 2016 Category: Science Source Type: news

Prevention Science Should Be a Higher Federal Funding Priority
This study highlights inadequate investment of federal funding for science that will help us better prevent chronic disease. Investing in prevention -- and prevention science -- should become a much higher priority for federal research. It's essential if the United States is to improve the health of our population and save future generations of Americans from the burden of preventable disease.
Source: Healthy Living - The Huffington Post - January 7, 2015 Category: Consumer Health News Source Type: news