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Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis
Conclusions: Our results show worldwide efficacy of BM-MSCs in improving functional outcomes in pre-clinical animal models of stroke and support testing these cells in clinical trials in various ranges of time windows using different delivery routes. The continued growing number of publications showing functional benefit of BM-MSCs are now adding limited value to an oversaturated literature spanning 18 years. Researchers should focus on identifying definitive mechanisms on how BM-MSCs lead to benefit in stroke models. Introduction Ischemic stroke is the 5th leading cause of death and the leading cause of long term di...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Factors Determining Consent in a Randomized Trial of Intra-arterial Stem Cell Therapy for Sub-Acute Ischemic Stroke (P2.386)
Conclusions: There was a relatively high rate of consent among eligible patients in the first US intra-arterial trial of stem cell therapy for stroke. Approaching LAR for consent was found not to influence consenting rates.Disclosure: Dr. Ramdas has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Haussen has nothing to disclose. Dr. McBee has nothing to disclose. Dr. Rutledge has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Dart Neuroscience as a consultant. Dr. Savitz has received research support from NIH T32 grant. Dr. Hinson has nothing to dis...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramdas, K., Pafford, R., Haussen, D., McBee, D., Rutledge, J., Huang, D., Savitz, S., Hinson, J., Yavagal, D. Tags: Research Methodology and Patient Education Source Type: research