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rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome
Conclusions Behavioral outcomes are improved with females with higher endogenous estrogen levels treated with standard dose antiplatelet loading. This is the first non-rodent study to demonstrate that higher endogenous estrogen levels in female rabbits appear to be neuroprotective in ischemic stroke. This research supports the further study of the effect of endogenous estrogen levels on outcome with standard dose antiplatelet loading in stroke patients not eligible for revascularization therapies.
Source: Biology of Sex Differences - July 15, 2014 Category: Biology Source Type: research

Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats
In conclusion, activation of coagulation cascade is a triggering stimulus in the initiation of CCl4-induced liver fibrosis and the anticoagulant drugs may exert promising anti-fibrotic effect.Graphical abstract
Source: Life Sciences - June 1, 2019 Category: Biology Source Type: research