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Total 155 results found since Jan 2013.
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
LINC01638 Sustains Human Mesenchymal Stem Cell Self-Renewal and Competency for Osteogenic Cell Fate
Res Sq. 2023 Aug 28:rs.3.rs-3210911. doi: 10.21203/rs.3.rs-3210911/v1. Preprint.ABSTRACTThe skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of osteogenesis by lncRNAs as mediators of commitment to the bone phenotype is largely unexplored. We focused on LINC01638, which is highly expressed in hMSCs and has been studied in cancers, but not in regulating osteogenesis. We demonstrated that LINC01638 promotes initiation of the osteoblast phenoty...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jonathan Gordon Coralee E Tye Bodhisatwa Banerjee Prachi N Ghule Andre J Wijnen Fleur S Kabala Natalie A Page Michelle M Falcone Janet L Stein Gary S Stein Jane B Lian Source Type: research
Effects of nicotine content and preferred flavor on subjective responses to e-cigarettes: A randomized, placebo-controlled laboratory study
CONCLUSIONS: These findings support differential and non-interactive effects of e-liquid nicotine content and flavor on reinforcing effects of e-cigarettes.IMPLICATIONS: E-liquid flavor and nicotine content have independent, non-interactive effects on subjective responses to vaping under controlled laboratory conditions. Among regular e-cigarette users, vaping a preferred flavor increased taste and satisfaction, but did not interact with nicotine to alter reward or craving. Further research on the ways in which these subjective effects may motivate vaping behavior among different populations of e-cigarette users would be u...
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Michael P Bremmer Alana M Campbell Kai Xia Robert Tarran Susan S Girdler Christian S Hendershot Source Type: research
