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Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood–brain barrier in mice
Conclusions Nicotine pre-exposure reduced the IR-enhanced GLUT1 transporter function and expression at the BBB in a focal brain ischemia mouse model. These studies suggest that nicotine exposure prior to stroke could create an enhanced glucose deprived state at the neurovascular unit (NVU) and could provide an additional vulnerability to enhanced stroke injury.
Source: Fluids and Barriers of the CNS - April 29, 2015 Category: Neuroscience Source Type: research

Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood–brain barrier in mice
In this study, we investigated the effects of nicotine on carrier-mediated glucose transport into ischemic brain. Specifically, the present study investigates glucose transporter-1 (GLUT1) function and expression at the BBB in a focal brain ischemia model of mice pre-exposed to nicotine. Methods: Nicotine was administrated subcutaneously by osmotic pump at the dose of 4.5 mg/kg/day for 1, 7, or 14 days to reflect the plasma levels seen in smokers. Ischemic-reperfusion (IR) injury was induced by 1 h transient middle cerebral artery occlusion (tMCAO) and 24 h reperfusion. Glucose transport was estimated using an in situ ...
Source: Cerebrospinal Fluid Research - April 29, 2015 Category: Neurology Authors: Kaushik ShahPurushotham BoreddyThomas Abbruscato Source Type: research