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Specialty: Materials Science
Drug: Magnesium
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Total 214 results found since Jan 2013.
A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration
Biomaterials. 2023 Aug 4;301:122266. doi: 10.1016/j.biomaterials.2023.122266. Online ahead of print.ABSTRACTConductive nano-materials and electrical stimulation (ES) have been recognized as a synergetic therapy for ordinary excitable tissue repair. It is worth noting that hard tissues, such as bone tissue, possess bioelectrical properties as well. However, insufficient attention is paid to the synergetic therapy for bone defect regeneration via conductive biomaterials with ES. Here, a novel nano-conductive hydrogel comprising calcium phosphate-PEDOT:PSS-magnesium titanate-methacrylated alginate (CPM@MA) was synthesized for...
Source: Biomaterials - August 19, 2023 Category: Materials Science Authors: Congcong Yu Xiaozhang Ying Mohammad-Ali Shahbazi Linjun Yang Zaiqiang Ma Lin Ye Wentao Yang Rongtai Sun Tianyuan Gu Ruikang Tang Shunwu Fan Shasha Yao Source Type: research
pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy
This study reveals a useful strategy to develop multifunctional coatings on bioabsorbable Mg alloys for orthopedic implants.PMID:37467596 | DOI:10.1016/j.biomaterials.2023.122237
Source: Biomaterials - July 19, 2023 Category: Materials Science Authors: Yanbin Zhao Peng He Junyan Yao Mei Li Bin Wang Linyuan Han Zhihai Huang Chao Guo Jing Bai Feng Xue Yu Cong Weihua Cai Paul K Chu Chenglin Chu Source Type: research
Fabrication and evaluation of PLA/MgAl < sub > 2 < /sub > O < sub > 4 < /sub > scaffolds manufactured through 3D printing method
In this study, we synthesized magnesium aluminate spinel (MgAl2O4) with a particle size ranging from 35 to 70 nm using a facile combustion approach. Then, we used a 3D printing (FDM) machine to produce PLA/x wt% MgAl2O4 (x = 0, 2, 4, 6, and 8) scaffolds. To investigate the crystal structure, microstructure, biodegradability, and thermal characteristics of the produced materials, we employed X-ray diffraction analysis (XRD), field emission scanning electron microscope (FESEM), Inductively Coupled Plasma (ICP), Simultaneous Thermal Analysis (STA), and compressive strength analyses. The results showed that PLA/6 wt% MgAl2O4 s...
Source: Journal of the Mechanical Behavior of Biomedical Materials - July 14, 2023 Category: Materials Science Authors: Mehran Ghodrati Seyed Mahdi Rafiaei Lobat Tayebi Source Type: research
Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery
Biomaterials. 2023 Jul 1;301:122230. doi: 10.1016/j.biomaterials.2023.122230. Online ahead of print.ABSTRACTThe metabolic disorder of hepatocytes in non-alcoholic fatty liver disease (NAFLD) leads to the formation of an iron pool which induces the Fenton reaction-derived ferroptosis and the deterioration of liver disease. The elimination of the iron pool for the removal of Fenton reactions is vitally important to prevent the evolution of NAFLD, but quite challenging. In this work, we discover that free heme in the iron pool of NAFLD can catalyze the hydrogenation of H2O2/‧OH to block the heme-based Fenton reaction for th...
Source: Biomaterials - July 7, 2023 Category: Materials Science Authors: Min Zhao Zhaokui Jin Chao Xia Shengqiang Chen Lingting Zeng Shucun Qin Qianjun He Source Type: research
Mechanical, corrosion and biological behavior of centrifugal casting processed Mg-2Zn-1Mn alloy reinforced with β Tricalciumphosphate (βTCP) for orthopaedic applications
J Mech Behav Biomed Mater. 2023 Jun 19;144:105983. doi: 10.1016/j.jmbbm.2023.105983. Online ahead of print.ABSTRACTZinc and manganese were selected to develop magnesium alloys along with the bioactive ceramic β Tricalciumphosphate (βTCP) for biomedical applications fabricated by centrifugal casting. Microstructure, mechanical properties, corrosion properties, and biocompatibility of the Mg-2Zn-1Mn-xβTCP (x = 0, 2.5, 5 wt%) alloys have been investigated by use of an optical microscope, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) analysis, XRD analysis, mechanical testing, cell toxic...
Source: Journal of the Mechanical Behavior of Biomedical Materials - June 26, 2023 Category: Materials Science Authors: Vignesh Chandran Chockalingam Kunjan Velkannan Veerapandian Ramesh Kannan Source Type: research
Strength and ductility loss of Magnesium-Gadolinium due to corrosion in physiological environment: Experiments and modeling
J Mech Behav Biomed Mater. 2023 Jun 1;144:105939. doi: 10.1016/j.jmbbm.2023.105939. Online ahead of print.ABSTRACTWe propose a computational framework to study the effect of corrosion on the mechanical strength of magnesium (Mg) samples. Our work is motivated by the need to predict the residual strength of biomedical Mg implants after a given period of degradation in a physiological environment. To model corrosion, a mass-diffusion type model is used that accounts for localised corrosion using Weibull statistics. The overall mass loss is prescribed (e.g., based on experimental data). The mechanical behaviour of the Mg samp...
Source: Journal of the Mechanical Behavior of Biomedical Materials - June 22, 2023 Category: Materials Science Authors: Dirk Steglich Jacques Besson Inken Reinke Heike Helmholz Monika Luczak Vasil M Garamus Bj örn Wiese Daniel H öche Christian J Cyron Regine Willumeit-R ömer Source Type: research
Sintering densification mechanism and mechanical properties of the 3D-printed high-melting-point-difference magnesium oxide/calcium phosphate composite bio-ceramic scaffold
In this study, we investigated ceramic scaffolds with varying MgO contents and sintering temperatures. We also discussed the co-sintering densification mechanism of high and low melting-point materials associated with composite ceramic scaffolds. During sintering, a liquid phase was generated, which filled up the pores generated during the vaporization of additives (such as resin) under the influence of capillary force. This led to an increase in the extent of ceramic densification realized. Moreover, we found ceramic scaffolds with 80 wt% MgO exhibited the best mechanical performance. This kind of composite scaffold perfo...
Source: Journal of the Mechanical Behavior of Biomedical Materials - June 20, 2023 Category: Materials Science Authors: Mengxing Ge Deqiao Xie Youwen Yang Zongjun Tian Source Type: research
An investigation on the fabrication and characterization of friction stir processed nano-HAp reinforced AZ91D magnesium matrix surface composite for bio-implants
J Mech Behav Biomed Mater. 2023 May 17;143:105918. doi: 10.1016/j.jmbbm.2023.105918. Online ahead of print.ABSTRACTIn the present research, friction stir processed (FSPed) nano-hydroxyapatite reinforced AZ91D magnesium matrix surface composite has been developed with improved ultimate tensile strength (UTS) and biological performance, which are needed for the bio-implants. Nano-hydroxyapatite reinforcement with varying proportions (5.8%, 8.3%, and 12.5%) was introduced into the AZ91-D parent material (PM) by the grooving method with different grooves of 0.5, 1 & 1.5 mm of width and 2 mm depth machined on the surface of...
Source: Journal of the Mechanical Behavior of Biomedical Materials - May 21, 2023 Category: Materials Science Authors: Satpal Kundu Lalit Thakur Source Type: research
An injectable porous bioactive magnesium phosphate bone cement foamed with calcium carbonate and citric acid for periodontal bone regeneration
In this study, different concentrations (0-5%) of calcium carbonate and citric acid (CA) were used as foaming agents to prepare porous MPC. The MPC containing 3% CaCO3/CA exhibited the best physicochemical properties, including greater porosity, improved injectability, extended setting time, and decreased hydration temperature. The proliferation and adhesion of cells on 3%CaCO3/CA-MPC were higher than those on MPC alone. To explore its osteogenesis in vivo, 3% CaCO3/CA-MPC and Bio-Oss® bone powder were implanted into periodontal bone defects in rats for 4 weeks and 12 weeks, respectively. Micro-CT and histological analysi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 23, 2023 Category: Materials Science Authors: Jiawen Wang Ziqing Cheng Duanjing Chen Guangyue Li Jie Chen Kai Wang Ling Xu Jiao Huang Source Type: research
Antibacterial and physical properties of resin cements containing MgO nanoparticles
J Mech Behav Biomed Mater. 2023 Apr 5;142:105815. doi: 10.1016/j.jmbbm.2023.105815. Online ahead of print.ABSTRACTCariogenic bacteria and dental plaque biofilm at prosthesis margins are considered a primary risk factor for failed restorations. Resin cement containing antibacterial agents can be beneficial in controlling bacteria and biofilm. This work aimed to evaluate the impact of incorporating magnesium oxide nanoparticles (MgONPs) as an antibacterial filler into dual-cure resin cement on bacteriostatic activity and physical properties, including mechanical, bonding, and physicochemical properties, as well as performanc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 17, 2023 Category: Materials Science Authors: Yuan Wang Zhongyuan Wu Ting Wang Jing Tian Zixuan Zhou Di Guo Bruna S H Tonin Zhou Ye Haiping Xu Jing Fu Source Type: research
