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Drug: Lortab
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Total 778 results found since Jan 2013.
Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity
CONCLUSIONS: Platelet oxygen consumption as a measure of mitochondrial function may be useful as a biomarker of hepatic APAP toxicity in the setting of moderate to severe overdose. Treatment with 4-MP decreases hepatic necrosis and may mitigate the harmful effects of APAP on platelet mitochondrial function detected via POC.PMID:37644341 | DOI:10.1007/s13181-023-00964-0
Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Carolyn Fox Michael L Ekaney Michael Runyon Hieu M Nguyen Philip J Turk Iain H McKillop Christine M Murphy Source Type: research
Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells
Arch Toxicol. 2023 Aug 28. doi: 10.1007/s00204-023-03569-2. Online ahead of print.ABSTRACTAcetaminophen (APAP) belong among the most used analgesics and antipyretics. It is structurally derived from p-aminophenol (PAP), a potent inducer of kidney toxicity. Both compounds can be metabolized to oxidation products and conjugated with glutathione. The glutathione-conjugates can be cleaved to provide cysteine conjugates considered as generally nontoxic. The aim of the present report was to synthesize and to purify both APAP- and PAP-cysteine conjugates and, as the first study at all, to evaluate their biological effects in huma...
Source: Archives of Toxicology - August 28, 2023 Category: Toxicology Authors: Tomas Rousar Jiri Handl Jan Capek Pavlina Nyvltova Erika Rousarova Miroslav Kubat Lenka Smid Jana Vanova David Malinak Kamil Musilek Petr Cesla Source Type: research
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction
Regul Toxicol Pharmacol. 2023 Aug 23:105480. doi: 10.1016/j.yrtph.2023.105480. Online ahead of print.ABSTRACTJNJ-10450232 (NTM-006) is a non-opioid, non-NSAID analgesic and antipyretic compound with structural similarity to acetaminophen. Preclinical models show comparable analgesia relative to acetaminophen and no evidence of hepatotoxicity associated with overdose. Moreover, it was safe and generally well tolerated in a First-in-Human Study. This single-dose, single-center, inpatient, randomized, double-blind study in moderate-to-severe acute pain following third molar extraction compared efficacy and safety of 250 mg an...
Source: Regulatory Toxicology and Pharmacology : RTP - August 25, 2023 Category: Toxicology Authors: Cathy K Gelotte Amy M Vakil Brenda A Zimmerman Peter Zannikos Rajesh Mishra Gary Eichenbaum Edwin K Kuffner Christopher M Flores Source Type: research
Development of a lung-liver in vitro coculture model for inhalation-like toxicity assessment
Toxicol In Vitro. 2023 Jul 10:105641. doi: 10.1016/j.tiv.2023.105641. Online ahead of print.ABSTRACTAnimal models are considered prime study models for inhalation-like toxicity assessment. However, in light of animal experimentation reduction (3Rs), we developed and investigated an alternative in vitro method to study systemic-like responses to inhalation-like exposures. A coculture platform was established to emulate inter-organ crosstalks between a pulmonary barrier, which constitutes the route of entry of inhaled compounds, and the liver, which plays a major role in xenobiotic metabolism. Both compartments (Calu-3 inser...
Source: Toxicology in Vitro - July 12, 2023 Category: Toxicology Authors: Sabrina Madiedo-Podvrsan Louise Sebillet Thomas Martinez Salimata Bacari Fengping Zhu Marie Cattelin Eric Leclerc Franck Merlier Rachid Jellali Ghislaine Lacroix Muriel Vayssade Source Type: research
