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Breastfeeding or breast milk for procedural pain in neonates
CONCLUSIONS: Moderate-/low-certainty evidence suggests that breastfeeding or supplemental breast milk may reduce pain in neonates undergoing painful procedures compared to no intervention/positioning/holding or placebo or non-pharmacological interventions. Low-certainty evidence suggests that moderate concentration (20% to 33%) glucose/sucrose may lead to little or no difference in reducing pain compared to breastfeeding. The effectiveness of breast milk for painful procedures should be studied in the preterm population, as there are currently a limited number of studies that have assessed its effectiveness in this populat...
Source: Cochrane Database of Systematic Reviews - August 29, 2023 Category: General Medicine Authors: Prakeshkumar S Shah Ranjit Torgalkar Vibhuti S Shah Source Type: research

Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children
CONCLUSIONS: Despite explicit guideline recommendations on the use of analgesics in children with AOM, the current evidence on the effectiveness of paracetamol or NSAIDs, alone or combined, in children with AOM is limited. Paracetamol and ibuprofen as monotherapies may be more effective than placebo in relieving short-term ear pain in children with AOM. The evidence is very uncertain for the effect of ibuprofen versus paracetamol on relieving short-term ear pain in children with AOM, as well as for the effectiveness of ibuprofen plus paracetamol versus paracetamol alone, thereby preventing any firm conclusions. Further res...
Source: Cochrane Database of Systematic Reviews - August 18, 2023 Category: General Medicine Authors: Joline L H de S évaux Roger Amj Damoiseaux Alma C van de Pol Vittoria Lutje Alastair D Hay Paul Little Anne Gm Schilder Roderick P Venekamp Source Type: research

Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning
We reported a case of a 15-year- old girl referred to our Emergency Department 3 hours after ingestion of 10 g of paracetamol for suicidal purposes. She promptly started the administration of intravenous N-acetylcysteine (NAC) and the patient was discharged after 5 days of hospitalization in good clinical condition and with neuropsychiatric follow-up. Our case shows that the timing of the intravenous NAC administration is considered the most important factor in the prevention of acetaminophen-induced hepatic failure, despite high serum levels after acetaminophen ingestion.PMID:37247196 | DOI:10.23750/abm.v94iS1.13714
Source: Acta Bio-Medica : Atenei Parmensis - May 29, 2023 Category: General Medicine Authors: Serena Ferretti Antonietta Curatola Antonio Chiaretti Benedetta Graglia Antonio Gatto Lavinia Capossela Valeria Pansini Source Type: research

A Case of Progressive Cholestatic Drug-Induced Liver Injury Due to Terbinafine
CONCLUSIONS: Non-acetaminophen drug-induced liver injury is idiosyncratic. Complications including acute liver failure and vanishing bile duct syndrome can be slow to develop, so monitoring for them is important over longitudinal follow-up.PMID:37141482
Source: WMJ - May 4, 2023 Category: General Medicine Authors: Dana Ley Jessica Musto Adnan Said Source Type: research

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