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Drug: Lortab
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Total 4663 results found since Jan 2013.
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.
CONCLUSIONS: More women experienced pain relief, and fewer had additional pain relief, with paracetamol compared with placebo, although potential adverse effects were not assessed and generally the quality of studies was unclear.
PMID: 23440827 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - March 2, 2013 Category: Journals (General) Authors: Chou D, Abalos E, Gyte GM, Gülmezoglu AM Tags: Cochrane Database Syst Rev Source Type: research
Question 2: Does a failure to respond to antipyretics predict serious illness in children with a fever?
Clinical scenario You are a senior house officer (SHO) working in a busy district general hospital. A 9-month-old boy is brought in by his parents with a fever of 2 days duration. There is no obvious focus but the child appears well. A urine dipstick is negative. When reviewing the child, the registrar is concerned to learn that the fever has not responded to paracetamol (acetaminophen). You wonder if there is any evidence that a febrile child is more likely to have a serious illness if their fever fails to respond to antipyretics. Structured question In children with a fever (population) does a failure to respond to ...
Source: Archives of Disease in Childhood - July 11, 2013 Category: Pediatrics Authors: King, D. Tags: ADC Archimedes, Oncology, Epidemiologic studies, Drugs: infectious diseases, Meningitis, Pneumonia (infectious disease), TB and other respiratory infections, Infection (neurology), Pneumonia (respiratory medicine) Source Type: research
High‐alert medications in a French paediatric university hospital
ConclusionsThis project was part of the new safety strategies developed in a paediatric hospital. We set out to make a list of HAM relevant to paediatrics with additional safety measures to prevent medication errors associated and a ‘joker’ system. The various safety measures, such as double‐checking of HAM prescriptions, should be reviewed during the year following their implementation. This list, which was developed in our hospital specifically for use in paediatrics, can be adapted for use in other paediatric departments.
Source: Journal of Evaluation in Clinical Practice - January 6, 2015 Category: Journals (General) Authors: Julie Bataille, Sonia Prot‐Labarthe, Olivier Bourdon, Perrine Joret, Françoise Brion, Jean‐François Hartmann Tags: Original Article Source Type: research
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants.
CONCLUSIONS: Although a limited number of infants with a PDA have been studied in randomised trials of low to moderate quality according to GRADE, oral paracetamol appears to be as effective in closing a PDA as oral ibuprofen. In view of a recent report in mice of adverse effects on the developing brain from paracetamol, and another report of an association between prenatal paracetamol and the development of autism or autism spectrum disorder in childhood, long-term follow-up to at least 18 to 24 months postnatal age must be incorporated in any studies of paracetamol in the newborn population. Such trials are required befo...
Source: Cochrane Database of Systematic Reviews - March 11, 2015 Category: Journals (General) Authors: Ohlsson A, Shah PS Tags: Cochrane Database Syst Rev Source Type: research
The association between paracetamol and asthma is still under debate.
CONCLUSIONS: There are many arguments that suggest a relationship between the use of paracetamol with the appearance of asthmatic symptoms, however the evidence is inconclusive.
PMID: 27575940 [PubMed - as supplied by publisher]
Source: Journal of Asthma - September 1, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research
Tramadol with or without paracetamol (acetaminophen) for cancer pain.
CONCLUSIONS: There is limited, very low quality, evidence from randomised controlled trials that tramadol produced pain relief in some adults with pain due to cancer and no evidence at all for children. There is very low quality evidence that it is not as effective as morphine. This review does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different is very high. The place of tramadol in managing cancer pain and its role as step 2 of the WHO analgesic ladder is unclear.
PMID: 28510996 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 16, 2017 Category: General Medicine Authors: Wiffen PJ, Derry S, Moore RA Tags: Cochrane Database Syst Rev Source Type: research
Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies.
Conclusions: The pharmaceutical substances investigated were shown to exhibit variable effects on root resorption. Although the overall quality of evidence provides the clinician with a cautious perspective on the strength of the relevant recommendations, good practice would suggest that it is important to identify patients consuming medications and consider the possible implications.
Registration: PROSPERO (CRD42017078208).
PMID: 29992228 [PubMed - as supplied by publisher]
Source: European Journal of Orthodontics - July 9, 2018 Category: Dentistry Authors: Makrygiannakis MA, Kaklamanos EG, Athanasiou AE Tags: Eur J Orthod Source Type: research
Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.
CONCLUSIONS: The paucity and low quality of existing data do not provide sufficient evidence to establish the role of paracetamol in reducing the effects of painful procedures in neonates. Paracetamol given after assisted vaginal birth may increase the response to later painful exposures. Paracetamol may reduce the total need for morphine following major surgery, and for this aspect of paracetamol use, further research is needed.
PMID: 31985830 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - January 26, 2020 Category: General Medicine Authors: Ohlsson A, Shah PS Tags: Cochrane Database Syst Rev Source Type: research
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Single-dose intravenous ibuprofen for acute postoperative pain in adults
CONCLUSIONS: There is insufficient evidence to support or refute the suggestion that IV ibuprofen is effective and safe for acute postoperative pain in adults.PMID:34499349 | PMC:PMC8428326 | DOI:10.1002/14651858.CD013264.pub2
Source: Cochrane Database of Systematic Reviews - September 9, 2021 Category: General Medicine Authors: McKenzie C Ferguson Roman Schumann Sean Gallagher Ewan D McNicol Source Type: research
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period
CONCLUSIONS: A single dose of paracetamol may improve perineal pain relief following vaginal birth, and may reduce the need for additional pain relief. Potential adverse effects for both women and neonates were not appropriately assessed. Any further trials should also address the gaps in evidence concerning maternal outcomes such as satisfaction with postnatal care, maternal functioning/well-being (emotional attachment, self-efficacy, competence, autonomy, confidence, self-care, coping skills) and neonatal drug adverse effects.PMID:34559424 | PMC:PMC8094229 | DOI:10.1002/14651858.CD008407.pub3
Source: Cochrane Database of Systematic Reviews - September 24, 2021 Category: General Medicine Authors: Edgardo Abalos Yanina Sguassero Gillian Ml Gyte Source Type: research
Prophylactic cyclo-oxygenase inhibitor drugs for the prevention of morbidity and mortality in preterm infants: a network meta-analysis
CONCLUSIONS: Prophylactic indomethacin probably results in a small reduction in severe IVH and moderate reduction in mortality and surgical PDA closure (moderate-certainty), may result in a small increase in CLD (low-certainty) and results in trivial differences in NEC (high-certainty), gastrointestinal perforation (moderate-certainty) and cerebral palsy (low-certainty). Prophylactic ibuprofen probably results in a small reduction in severe IVH and moderate reduction in surgical PDA closure (moderate-certainty), may result in a moderate reduction in mortality (low-certainty) and trivial differences in CLD (low-certainty) a...
Source: Cochrane Database of Systematic Reviews - April 1, 2022 Category: General Medicine Authors: Souvik Mitra Courtney E Gardner Abigale MacLellan Tim Disher Danielle M Styranko Marsha Campbell-Yeo Stefan Kuhle Bradley C Johnston Jon Dorling Source Type: research
Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews
CONCLUSIONS: This overview summarised the evidence from 16 Cochrane Reviews of RCTs regarding the effects of interventions for the prevention and treatment of PDA in preterm infants. Prophylactic indomethacin reduces severe IVH, but does not appear to affect the composite outcome of death or moderate/severe neurodevelopmental disability. Prophylactic ibuprofen probably marginally reduces severe IVH (moderate-certainty evidence), while the evidence is very uncertain on the effect of prophylactic acetaminophen on severe IVH. All available prostaglandin inhibitor drugs appear to be effective in symptomatic PDA closure compare...
Source: Cochrane Database of Systematic Reviews - April 11, 2023 Category: General Medicine Authors: Souvik Mitra Willem P de Boode Dany E Weisz Prakeshkumar S Shah Source Type: research
