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Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
Biol Trace Elem Res. 2023 Sep 13. doi: 10.1007/s12011-023-03845-3. Online ahead of print.ABSTRACTOverdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and antipyretic medication, is one of the main causes of drug-induced acute liver failure around the world. Oxidative stress contributes to this hepatotoxicity. Antioxidants are known to protect the liver from oxidative stress. Selenium, a potent antioxidant, is a commonly used micronutrient. Here, we evaluated the protective effect of selenium on acetaminophen-induced hepatotoxicity. Treating Wistar albino mice with sodium selenite (1 mg/kg) befo...
Source: Biological Trace Element Research - September 13, 2023 Category: Biology Authors: Mylanayakanahosahalli Chandrashekar Indumathi Kamatam Swetha Kandahalli Venkataranganayaka Abhilasha Shiva Siddappa Shivamadhaiah Manjula Kumar Govinda Keerthi Prasad Chu-Huang Chen Gopal Kedihithlu Marathe Source Type: research

Systematic study of the synergistic and kinetics effects on the removal of contaminants of emerging concern from water by ultrasound in the presence of diverse oxidants
Environ Sci Pollut Res Int. 2023 Aug 26. doi: 10.1007/s11356-023-29189-y. Online ahead of print.ABSTRACTThe enhancement of the ultrasound system by adding diverse oxidants to remove a model contaminant (acetaminophen, ACE) in water was investigated. Different parameters were evaluated to study their effect on both the degradation kinetics and the synergy of the combination. The variables studied were the ultrasonic frequency (575, 858, and 1135 kHz), type of oxidant (hydrogen peroxide, sodium peroxydisulfate (or persulfate, PDS), and potassium peroxymonosulfate (PMS)), ACE concentration (4, 8, and 40 µM), and oxidant conc...
Source: Environmental Science and Pollution Research International - August 26, 2023 Category: Environmental Health Authors: Sandra E Estrada-Fl órez Efra ím A Serna-Galvis Judy Lee Ricardo A Torres-Palma Source Type: research

Sodium Pentaborate Prevents Acetaminophen-Induced Hepatorenal Injury by Suppressing Oxidative Stress, Lipid Peroxidation, Apoptosis, and Inflammatory Cytokines in Rats
This study showed that boron protects rats from the harmful effects of APAP by acting as an anti-inflammatory, antioxidant, and anti-apoptotic agent.PMID:37393388 | DOI:10.1007/s12011-023-03755-4
Source: Biological Trace Element Research - July 1, 2023 Category: Biology Authors: Esra Aktas Senocak Necati Utlu Seyda Kurt Sefa Kucukler Fatih Mehmet Kandemir Source Type: research

Top studies of 2022 relevant to primary care: From the PEER team
CONCLUSION: Research published in 2022 yielded several high-quality articles on various conditions relevant to primary care, including hypertension, heart failure, asthma, and diabetes.PMID:37172982 | PMC:PMC10177638 | DOI:10.46747/cfp.6905325
Source: Canadian Family Physician Medecin de Famille Canadien - May 12, 2023 Category: Primary Care Authors: Danielle Perry Samantha S Moe Betsy Thomas Adrienne J Lindblad Jessica Kirkwood Jamie Falk Jen Potter Allison Paige G Michael Allan Source Type: research

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