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Brain morphometric features predict medication response in youth with bipolar disorder: a prospective randomized clinical trial
CONCLUSIONS: These findings demonstrate that pre-treatment morphometric measures and acute brain morphometric changes can serve as medication response predictors in pediatric BD. Brain morphometric features may provide promising biomarkers for developing biologically-informed treatment outcome prediction and patient stratification tools for BD treatment development.PMID:35392995 | DOI:10.1017/S0033291722000757
Source: Psychological Medicine - April 8, 2022 Category: Psychiatry Authors: Du Lei Kun Qin Wenbin Li Walter H L Pinaya Maxwell J Tallman L Rodrigo Patino Jeffrey R Strawn David Fleck Christina C Klein Su Lui Qiyong Gong Caleb M Adler Andrea Mechelli John A Sweeney Melissa P DelBello Source Type: research

The Impact of Lithium on Brain Function in Bipolar Disorder: An Updated Review of Functional Magnetic Resonance Imaging Studies
AbstractLithium remains a gold standard treatment for bipolar disorder (BD), and functional magnetic resonance imaging (fMRI) studies have contributed to clarifying its impact on neural circuitries in affected individuals. However, the specific neurobiological mechanisms through which lithium exerts its effects on brain function are not fully understood. In this review, we aimed to summarize the results of recent fMRI studies evaluating the impact of lithium on brain functional activity and connectivity in patients diagnosed with BD. We performed a literature search of available sources found in the PubMed database reporte...
Source: CNS Drugs - November 12, 2021 Category: Neurology Source Type: research

Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Observation of memory effects associated with degradation of rechargeable lithium-ion cells using ultrafast surface-scan magnetic resonance imaging
J. Mater. Chem. A, 2021, Advance Article DOI: 10.1039/D1TA05747B, PaperKonstantin Romanenko, Alexej Jerschow Batteries share their “health problems” and “memories” of hazardous life-cycle eventsvia DC-induced magnetic field patterns revealed by MRI. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - September 9, 2021 Category: Chemistry Authors: Konstantin Romanenko Source Type: research

New insights into the thermal behaviour of organic ionic plastic crystals: magnetic resonance imaging of polycrystalline morphology alterations induced by solid-solid phase transitions
Phys. Chem. Chem. Phys., 2015, Accepted ManuscriptDOI: 10.1039/C5CP03294F, PaperKonstantin Romanenko, Jenny Pringle, Luke Austin O'Dell, Maria ForsythOrganic ionic plastic crystals (OIPCs) show strong potential as solid-state electrolytes for lithium battery applications, demonstrating promising electrochemical performance and eliminating the need for a volatile and flammable liquid electrolyte....The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - June 23, 2015 Category: Chemistry Authors: Konstantin Romanenko Source Type: research