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Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia
Neurodegener Dis. 2023 Sep 4. doi: 10.1159/000533797. Online ahead of print.ABSTRACTBACKGROUND: Although Alzheimer's disease (AD) is the most common form of dementia, the effective treatment of AD is not available currently. Multiple trials of drugs, which were developed based on the amyloid hypothesis of AD, have not been highly successful to improve cognitive and other symptoms in AD patients, suggesting that it is necessary to explore additional and alternative approaches for the disease-modifying treatment of AD. The diverse lines of evidence have revealed that lithium reduces amyloid and tau pathology, attenuates neur...
Source: Neuro-Degenerative Diseases - September 4, 2023 Category: Neurology Authors: Seong Sool Shim Ken Berglund Shan Ping Yu Source Type: research

Long Cycle-Life Ca Batteries with Poly(anthraquinonylsulfide) Cathodes and Ca-Sn Alloy Anodes
ChemSusChem. 2023 Aug 1:e202300932. doi: 10.1002/cssc.202300932. Online ahead of print.ABSTRACTCalcium (Ca) batteries are attractive post-lithium battery technologies, due to their potential to provide high-voltage and high-energy systems in a sustainable manner. We investigated herein 1,5- poly(anthraquinonylsulfide) (PAQS) for Ca-ion storage with calcium tetrakis(hexafluoroisopropyloxy)borate Ca[B(hfip)4]2 [hfip = OCH(CF3)2] electrolytes. It is demonstrated that PAQS could be synthesized in a cost-effective approach and be processed environmentally friendly into the electrodes. The PAQS cathodes could provide 94 mAh g-1 ...
Source: ChemSusChem - August 1, 2023 Category: Chemistry Authors: Daniel Bier Zhenyou Li Svetlana Klyatskaya Najoua Sbei Ananyo Roy Sibylle Riedel Maximilian Fichtner Mario Ruben Zhirong Zhao-Karger Source Type: research

Selectivity of cation transport across lipid membranes by the antibiotic salinomycin
Biochim Biophys Acta Biomembr. 2023 Jun 3:184182. doi: 10.1016/j.bbamem.2023.184182. Online ahead of print.ABSTRACTThe ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical for its therapeutic activity, are rather scarce. In the present work, we studied the ability of salinomycin to exert cation/H+-exchange across artificial bilayer lipid membranes (BLM) by measuring electrical potential on planar BLM in the presence of a protonophore and fluorescence responses of the...
Source: Biochimica et Biophysica Acta - June 5, 2023 Category: Biochemistry Authors: Tatyana I Rokitskaya Alexander M Firsov Ljudmila S Khailova Elena A Kotova Yuri N Antonenko Source Type: research

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