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Drug: Insulin

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Total 61154 results found since Jan 2013.

Making Decisions About Medications in Critically Ill Children: A Survey of Canadian Pediatric Critical Care Clinicians
Conclusions: The relative importance of many factors that clinicians consider when making decisions about medications varies by demographics, and depends on the clinical problem. This variability should be considered in quality improvement and knowledge translation interventions in this setting.
Source: Pediatric Critical Care Medicine - January 1, 2015 Category: Pediatrics Tags: Feature Articles Source Type: research

A Novel Framework Using Remote Telesimulation With Standardized Parents to Improve Research Staff Preparedness for Informed Consent in Pediatric Critical Care Research*
Conclusions: Remote telesimulation with standardized parents is feasible, acceptable, and associated with lower financial costs to prepare research staff to obtain informed consent from parents of critically ill children eligible for clinical research trials. Despite this novel approach, Heart And Lung Failure—Pediatric INsulin Titration study consent rates did not improve, suggesting that other factors influence parental consent and decision making in complex multicenter clinical research trials.
Source: Pediatric Critical Care Medicine - December 1, 2020 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

A Survey Demonstrating Lack of Consensus on the Sequence of Medications for Treatment of Hyperkalemia Among Pediatric Critical Care Providers*
Conclusion: This survey revealed notable variability in the choice and sequence of medications for treatment of life-threatening hyperkalemia with surprisingly few participants in compliance with the advanced cardiovascular life support hyperkalemia guidelines. A standardized approach for pediatric life-threatening hyperkalemia is recommended to improve resuscitation quality.
Source: Pediatric Critical Care Medicine - June 1, 2015 Category: Pediatrics Tags: Feature Articles Source Type: research

Targeting Glycemic Control After Pediatric Cardiac Surgery: The Influence of Age on Insulin Requirement*
This study investigated the impact of age on the pattern of hyperglycemia and insulin requirement in children after cardiac surgery. Design: Cohort study, based on a prospectively collected dataset for patients enrolled into the Control of Hyperglycemia in Pediatric Intensive Care trial. Setting: A 24-bedded multidisciplinary PICU. Patients: Children randomized to the tight glycemic control arm (target blood glucose, 4–7 mmol/L [72–126 mg/dL]) of the Control of Hyperglycemia in Pediatric Intensive Care trial following cardiac surgery. Children were categorized into four age groups (neonate, 1–30 d; infant, 31–365 d...
Source: Pediatric Critical Care Medicine - November 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

SCCM Pod-116 CCM: Diabetes, Insulin, and the Development of ALI
Michelle Gong, MD, MS, discusses her recent articled published in the August 2009 issue of Critical Care Medicine.
Source: SCCM PodCast - iCritical Care - September 24, 2009 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

Cell-Cycle Arrest Biomarkers: Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants*
Conclusions: These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.
Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Renal Critical Care Source Type: research

Impact of clinical pharmacist in an Indian Intensive Care Unit
Conclusion: Clinical pharmacist as a part of multidisciplinary team in our study was associated with a substantially lower rate of adverse drug event caused by medication errors, drug interactions, and drug incompatibilities.
Source: Indian Journal of Critical Care Medicine - February 8, 2016 Category: Intensive Care Authors: Mohamed HishamMudalipalayam N SivakumarGanesh Veerasekar Source Type: research

Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children
Objectives: Previous studies report worse short-term outcomes with hypoglycemia in critically ill children. These studies relied on intermittent blood glucose measurements, which may have introduced detection bias. We analyzed data from the Heart And Lung Failure-Pediatric INsulin Titration trial to determine the association of hypoglycemia with adverse short-term outcomes in critically ill children. Design: Nested case-control study. Setting: Thirty-five PICUs. A computerized algorithm that guided the timing of blood glucose measurements and titration of insulin infusion, continuous glucose monitors, and standardi...
Source: Critical Care Medicine - April 13, 2019 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery*
Conclusions: A FF strategy was not associated with changes to early enteral nutrition delivery. Inflammation, insulin resistance, and morbidity were similar, but FF may modify the relationship between inflammation and adverse event. Multicenter nutrition studies are possible and necessary in this vulnerable population.
Source: Pediatric Critical Care Medicine - July 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Liraglutide as an alternative to insulin for glycemic control in intensive care unit: A randomized, open-label, clinical study
Conclusion: Liraglutide is a viable alternative to insulin for glycemic control in the ICU. Further studies with a larger number of patients are required to confirm our findings.
Source: Indian Journal of Critical Care Medicine - September 14, 2017 Category: Intensive Care Authors: Vishesh Verma Narendra Kotwal Vimal Upreti Monish Nakra Yashpal Singh K Anand Shankar Amit Nachankar K.V.S. Hari Kumar Source Type: research

Admetsys Develops Artificial Pancreas for Critical Care
Admetsys, a company headquartered in Boston, has developed a system for controlling blood glucose levels in critical care patients. Essentially an artificial pancreas, the system relies on a lab-on-a-chip that’s embedded within an intravenous c...
Source: Medgadget - May 17, 2018 Category: Medical Devices Authors: Editors Tags: Anesthesiology Cardiology Critical Care Medicine Pediatrics Source Type: blogs

Tight Glycemic Control With Insulin Does Not Affect Skeletal Muscle Degradation During the Early Postoperative Period Following Pediatric Cardiac Surgery*
The objective was to evaluate the effect of postoperative tight glycemic control and clinically dosed insulin on skeletal muscle degradation in children after cardiac surgery with cardiopulmonary bypass. Design: Secondary analysis of a two-center, prospective randomized trial comparing tight glycemic control with standard care. Randomization was stratified by study center. Patients: Children 0–36 months who were admitted to the ICU after cardiac surgery requiring cardiopulmonary bypass. Interventions: In the tight glycemic control arm, insulin was titrated to maintain blood glucose between 80 and 110 mg/dL. Patients in t...
Source: Pediatric Critical Care Medicine - July 1, 2015 Category: Pediatrics Tags: Feature Articles Source Type: research

Challenging the One-Dose-Fits-All Model for Insulin in the Acute Treatment of Pediatric Diabetic Ketoacidosis. A Critical Appraisal of “Low-Dose Versus Standard-Dose Insulin in Pediatric Diabetic Ketoacidosis: A Randomized Clinical Trial” by Nallasamy et al (JAMA Pediatrics 2014; 168:999–1005)
Conclusions: Low-dose insulin infusion is noninferior to standard-dose insulin in the treatment of younger pediatric patients with diabetic ketoacidosis and may lead to fewer therapy-related complications.
Source: Pediatric Critical Care Medicine - October 1, 2016 Category: Pediatrics Tags: Online Journal Club Source Type: research

Blood glucose variability and outcomes in critically ill children
Conclusion: Glucose disorders were frequently observed in critically ill children. BG variability was associated with multiorgan dysfunction and increased ICU stay.
Source: Indian Journal of Critical Care Medicine - March 8, 2017 Category: Intensive Care Authors: Kirti Mahadeorao Naranje Banani Poddar Arpita Bhriguvanshi Richa Lal Afzal Azim Ratender K Singh Mohan Gurjar Arvind K Baronia Source Type: research