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Specialty: Cardiology
Drug: Insulin
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Total 191 results found since Jan 2013.
The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials
Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM. Systematic Review Registration: https:/...
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Zehua Zhang Yulin Leng Zhengtao Chen Xiaoxu Fu Qingzhi Liang Xi Peng Hongyan Xie Hong Gao Chunguang Xie Source Type: research
Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
Int J Mol Sci. 2023 Apr 27;24(9):7934. doi: 10.3390/ijms24097934.ABSTRACTIschemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35-74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants ...
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Anna Camps-Vilaro Isaac Subirana Rafel Ramos Miguel Cainzos-Achirica Helena Tizon-Marcos Montse Fito Irene R Degano Jaume Marrugat Source Type: research
U-shaped association between the triglyceride-glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease
CONCLUSIONS: A U-shaped association between the TyG index and AF incidence is observed in Americans without known cardiovascular diseases. Female sex may be a modifier in the association between the TyG index and AF incidence.PMID:37208737 | DOI:10.1186/s12933-023-01777-9
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Xiao Liu Ayiguli Abudukeremu Yuan Jiang Zhengyu Cao Maoxiong Wu Jianyong Ma Runlu Sun Wanbing He Zhiteng Chen Yangxin Chen Peng Yu Wengen Zhu Yuling Zhang Jingfeng Wang Source Type: research
Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database
The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG inde...
Source: Cardiovascular Diabetology - June 13, 2023 Category: Cardiology Authors: Weimin Cai, Jun Xu, Xiao Wu, Zhuoyan Chen, Liuwei Zeng, Xian Song, Yuan Zeng and Fujun Yu Tags: Research Source Type: research
Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats
CONCLUSIONS: Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats.PMID:37376883 | DOI:10.32725/jab.2023.009
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Mai Kakimoto Moe Fujii Ikumi Sato Koki Honma Hinako Nakayama Sora Kirihara Taketo Fukuoka Shang Ran Satoshi Hirohata Kazuya Kitamori Shusei Yamamoto Shogo Watanabe Source Type: research
Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research
Steady solution and its stability of a mathematical model of diabetic atherosclerosis
J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734.ABSTRACTAtherosclerosis is a leading cause of death worldwide. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation. Diabetic patients are twice as likely to have a heart attack or stroke. In this paper, we consider a simplified mathematical model for diabetic atherosclerosis involving LDL, HDL, glucose, insulin, free radicals (ROS), β cells, macrophages and foam cells, which satisfy a system of partial differential equations with a free boundary, the interface between the blood flow and th...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Xuming Xie Source Type: research
