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Left atrial appendage closure: First in man with the 4th generation watchman device
ConclusionsLAA closure with the 4th generation WATCHMAN device is feasible and safe. New technical features may contribute to a better performance of the occluder, particularly regarding the risk of pericardial effusions. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Jakob Ledwoch, Jennifer Franke, Maik Gonzaga, Stefan Bertog, Annkathrin Braut, Ilona Hofmann, Laura Vaskelyte, Sameer Gafoor, Vivek Reddy, Horst Sievert Tags: Valvular and Structural Heart Diseases Source Type: research

Evaluation of the efficacy and safety of dual antiplatelet therapy with or without warfarin in patients with a clinical indication for DAPT and chronic anticoagulation: A meta‐analysis of observational studies
Conclusions: All‐cause mortality appears similar in patients treated with TT or DAPT although TT was associated with higher rates of major bleeding and a lower risk for ischemic stroke. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Chirag Bavishi, Anna Koulova, Sripal Bangalore, Ashwin Sawant, Saurav Chatterjee, Sameer Ather, Jose Valencia, Nikolaus Sarafoff, Andrea Rubboli, Juhani K. Airaksinen, Gregory Y. H. Lip, Jacqueline E. Tamis‐Holland Tags: Coronary Artery Disease Source Type: research

Long-Term Outcomes of the Maze Procedure Combined With Mitral Valve Repair: Risk of Thromboembolism Without Anticoagulation Therapy.
CONCLUSIONS: Adopting appropriate selection criteria for discontinuing anticoagulation therapy, the majority of patients receiving concomitant mitral repair and the Maze procedure can discontinue warfarin with excellent long-term safety profiles. PMID: 26116476 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Hwang SK, Yoo JS, Kim JB, Jung SH, Choo SJ, Chung CH, Lee JW Tags: Ann Thorac Surg Source Type: research

Long-Term Outcomes of the Maze Procedure Combined With Mitral Valve Repair: Risk of Thromboembolism Without Anticoagulation Therapy
Conclusions Adopting appropriate selection criteria for discontinuing anticoagulation therapy, the majority of patients receiving concomitant mitral repair and the Maze procedure can discontinue warfarin with excellent long-term safety profiles.
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Simultaneous Carotid Artery Stenting and Heart Surgery: Expanded Experience of Hybrid Surgical Procedures
Conclusions Same-day hybrid approach appeared safe in terms of early and long-term results not only for CAS and isolated CABG but also for CAS and noncoronary isolated procedures. In complex cases, the rate of stroke and myocardial infarction seemed low; in-hospital mortality, as expected, was higher. Long-term survival appeared similarly satisfactory, thus confirming the hybrid approach as a valid therapeutic option for all patients with significant internal carotid artery stenosis associated with coronary and other cardiac lesions, at least for noncomplex cases.
Source: The Annals of Thoracic Surgery - February 19, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

The effects of a low international normalized ratio on thromboembolic and bleeding complications in patients with mechanical mitral valve replacement
Conclusions: This study showed that a target INRs of 2.0-2.5 are acceptable for preventing TEs and safe in terms of bleeding complications in patients with mechanical MVR.
Source: Journal of Cardiothoracic Surgery - May 7, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Ugur BalAlp AydinalpKerem YilmazEmre OzcalikSenem HasirciIlyas AtarBahadir GultekinAtilla SezginHaldun Muderrisoglu Source Type: research

Safety of percutaneous left atrial appendage closure with the amplatzer cardiac plug in patients with atrial fibrillation and contraindications to anticoagulation
Conclusion: Percutaneous LAA closure with the ACP in patients with contraindications to oral anticoagulation is safe. The stroke and bleeding risk after percutaneous LAA closure is lower than predicted by conventional risk scores. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - December 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Jens Wiebe, Stefan Bertog, Jennifer Franke, Olga Wettstein, Katharina Lehn, Ilona Hofmann, Laura Vaskelyte, Horst Sievert Tags: Original Study Source Type: research

Successful closure of residual leak following lariat procedure in a patient with high risk of stroke and hemorrhage
Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, CA) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel approach to close a gap following percutaneous LAA suture ligation. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 9, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Valvular and Structural Heart Diseases Source Type: research

Thromboembolism in a patient with a mechanical mitral valve during anticoagulation with dabigatran etexilate.
We report a 57-year-old man with a mechanical heart valve who experienced acute upper limb thromboembolism during dabigatran intake. Dabigatran might be inadequate for thromboprophylaxis after mechanical valve replacement. PMID: 24182477 [PubMed - in process]
Source: The Annals of Thoracic Surgery - November 1, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kuwauchi S, Watanabe S, Abe K, Yamasaki M, Ito J, Kawazoe K Tags: Ann Thorac Surg Source Type: research

Successful closure of residual leak following LARIAT procedure in a patient with high risk of stroke and hemorrhage.
Abstract Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, California) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel Removed: and effectiveapproach to close a gap following percutaneous LAA suture ligation. © 2013...
Source: Catheterization and Cardiovascular Interventions - October 2, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Research Article Source Type: research

232 * early anticoagulation therapy after bioprosthetic aortic valve implantation: comparing warfarin versus aspirin
Conclusions: This is to date the largest randomized trial comparing warfarin to aspirin as early anticoagulation therapy after implantation of bioprosthetic aortic valves. The results are not conclusive, but aspirin therapy seems as safe as warfarin therapy, and with significantly fewer gastrointestinal bleeding events, three months after surgery.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Rafiq, S., Steinbruchel, D. A., Moeller, C. H., Lund, J., Thiis, J. J., Koeber, L., Lilleoer, N. B., Olsen, P. S. Tags: Decision-making in aortic valve repair Source Type: research

Mitral valve repair and bioprosthetic replacement without postoperative anticoagulation does not increase the risk of stroke or mortality ADULT CARDIAC
CONCLUSIONS Despite current guidelines recommending postoperative anticoagulation following MVRR or bioprosthetic replacement, the avoidance of warfarin does not increase perioperative complications and has no impact on intermediate survival. Accordingly, a prospective randomized study to adjudicate the role of extended warfarin thromboprophylaxis in mitral valve surgery is warranted.
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Schwann, T. A., Engoren, M., Bonnell, M., Clancy, C., Khouri, S., Kabour, A., Jamil, T., Habib, R. H. Tags: ADULT CARDIAC Source Type: research

Variation in Warfarin Thromboprophylaxis After Mitral Valve Repair: Does Equipoise Exist and Is a Randomized Trial Warranted?
CONCLUSIONS: At present, half of patients are prescribed warfarin after isolated mitral valve repair in North American cardiac surgical practice which may impact the length of hospital stay. Although patient-level predictors of warfarin prescription exist, center- and surgeon-level variations are prominent. There is a pressing need for a randomized trial both to guide therapy and to ascertain the potential for resource conservation. PMID: 23706423 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 29, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Suri RM, Thourani VH, He X, Brennan JM, O'Brien SM, Rankin JS, Schaff HV, Gammie JS Tags: Ann Thorac Surg Source Type: research

Variation in Warfarin Thromboprophylaxis After Mitral Valve Repair: Does Equipoise Exist and Is a Randomized Trial Warranted? ORIGINAL ARTICLES: ADULT CARDIAC
Conclusions At present, half of patients are prescribed warfarin after isolated mitral valve repair in North American cardiac surgical practice which may impact the length of hospital stay. Although patient-level predictors of warfarin prescription exist, center- and surgeon-level variations are prominent. There is a pressing need for a randomized trial both to guide therapy and to ascertain the potential for resource conservation.
Source: The Annals of Thoracic Surgery - May 29, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Suri, R. M., Thourani, V. H., He, X., Brennan, J. M., O'Brien, S. M., Rankin, J. S., Schaff, H. V., Gammie, J. S. Tags: Valve disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

The impact of CHADS2 score on late stroke after the Cox maze procedure
Conclusions: The risk of stroke or transient ischemic attack in patients after a surgical Cox maze procedure was low and not associated with CHADS2 score or warfarin use. Given the known risks of warfarin, we recommend discontinuation of anticoagulation 3 months after the procedure if the patient has no evidence of atrial fibrillation, has discontinued antiarrhythmic medications, and is without any other indication for systemic anticoagulation.
Source: The Journal of Thoracic and Cardiovascular Surgery - July 23, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Mitchell Pet, Jason O. Robertson, Marci Bailey, Tracey J. Guthrie, Marc R. Moon, Jennifer S. Lawton, Andrew Rinne, Ralph J. Damiano, Hersh S. Maniar Tags: Acquired Cardiovascular Disease Source Type: research

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