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Identification of a nth-Like Gene Encoding an Endonuclease III in Campylobacter jejuni
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jej...
Source: Frontiers in Microbiology - April 9, 2019 Category: Microbiology Source Type: research

Pipe Dreams: Tapping into the Health Information in Our Sewers
The emerging field of sewage chemical-information mining is taking advantage of a readily available yet underappreciated resource: the untreated waste flowing under our feet and the biosolids remaining after treatment. It turns out that sewage and sewage sludge hold a wealth of data on chemical consumption and exposure, and potentially even the health status of whole communities.EHP Freezers at the National Sewage Sludge Repository hold hundreds of samples of raw sewage and sludge collected from more than 200 sites around the United States.© Arjunkrishna Venkatesan   Most chemicals...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News May 2016 Source Type: research