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Case Report: Cedecea lapagei Infection: Report of a Case in Peru and Review of the Literature
This study aimed to describe a case report of C. lapagei in Peru and systematically review the documented case reports of individuals infected with C. lapagei. A 59-year-old man who had become bedridden with Parkinson's disease and had epilepsy presented with a 1-week history of fever and sore throat and was admitted. Physical examination revealed an obtundation state and abolished vesicular murmur in the right hemithorax. During hospitalization, the patient was diagnosed with various infections, including tuberculosis, for which he received broad-spectrum antibiotics. In the absence of clinical improvement, a urine cultur...
Source: The American Journal of Tropical Medicine and Hygiene - June 20, 2023 Category: Tropical Medicine Authors: Ali Al-Kassab-C órdova Patricia Valdiviezo-Polo Juan R Ulloque-Badaracco Carlos L Honorio-Arroyo Miguel Hueda-Zavaleta Vicente A Benites-Zapata Source Type: research

Modification of bacterial cell membrane Dynamics and morphology upon exposure to sub inhibitory concentrations of ciprofloxacin
Biochim Biophys Acta Biomembr. 2022 Apr 21:183935. doi: 10.1016/j.bbamem.2022.183935. Online ahead of print.ABSTRACTCiprofloxacin (CPX), a second generation fluoroquinolone antibiotic, is used as a primary antibiotic for treatment against gastroenteritis, drug-resistant tuberculosis, and malignant otitis externa. CPX is a broad spectrum antibiotic that targets the DNA gyrase of both Gram-positive and Gram-negative bacteria. Irrational and improper usage of CPX results in emergence of CPX resistant organisms emphasizing the importance of using lethal doses of CPX. Here, we have systematically analysed the effect of CPX at s...
Source: Biochimica et Biophysica Acta - April 24, 2022 Category: Biochemistry Authors: Ilanila Ilangumaran Ponmalar Jitendriya Swain Jaydeep K Basu Source Type: research

Identification and characterization of pleiotropic high-persistence mutations in the beta subunit of the bacterial RNA polymerase
Antimicrob Agents Chemother. 2021 Aug 23:AAC0052221. doi: 10.1128/AAC.00522-21. Online ahead of print.ABSTRACTMutations conferring resistance to bactericidal antibiotics reduce average susceptibility of the mutant populations. It is unknown, however, how those mutations affect survival of individual bacteria. Since surviving bacteria can be a reservoir for recurring infections, it is important to know how survival rates may be affected by resistance mutations and by the choice of antibiotics. Here we present the evidence that: i) Escherichia coli mutants with 100-1000 times increased frequency of survival in ciprofloxacin,...
Source: Antimicrobial Agents and Chemotherapy - August 23, 2021 Category: Microbiology Authors: Lev Ostrer Yinduo Ji Arkady Khodursky Source Type: research

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