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Machine-learning assisted multicolor platform for multiplex detection of antibiotics in environmental water samples
Talanta. 2023 Sep 4;267:125153. doi: 10.1016/j.talanta.2023.125153. Online ahead of print.ABSTRACTAntibiotic (AB) resistance is one of daunting challenges of our time, attributed to overuse of ABs and usage of AB-contaminated food resources. Due to their detrimental impact on human health, development of visual detection methods for multiplex sensing of ABs is a top priority. In present study, a colorimetric sensor array consisting of two types of gold nanoparticles (AuNPs) were designed for identification and determination of ABs. Design principle of the probe was based on aggregation of AuNPs in the presence of ABs at di...
Source: Talanta - September 7, 2023 Category: Chemistry Authors: M Hassannia N Fahimi-Kashani M R Hormozi-Nezhad Source Type: research

Magnetic Fe < sub > 3 < /sub > O < sub > 4 < /sub > @COF@Ag SERS substrate combined with machine learning algorithms for detection of three quinolone antibiotics: Ciprofloxacin, norfloxacin and levofloxacin
Talanta. 2023 May 23;263:124725. doi: 10.1016/j.talanta.2023.124725. Online ahead of print.ABSTRACTQuinolone antibiotics have good antibacterial properties and are commonly used antibiotics in the dairy industry. Currently, the problem of excessive antibiotics in dairy products is very serious. As an ultra-sensitive detection technology, Surface-Enhanced Raman Scattering (SERS) was applied to the detection of quinolone antibiotics in this work. In order to classify and quantify three antibiotics (Ciprofloxacin, Norfloxacin, Levofloxacin) with highly similar molecular structures, a combination of magnetic COF-based SERS sub...
Source: Talanta - June 4, 2023 Category: Chemistry Authors: Zichen Yang Guoqing Chen Chaoqun Ma Jiao Gu Chun Zhu Lei Li Hui Gao Source Type: research

Effects of biochar addition on the fate of ciprofloxacin and its associated antibiotic tolerance in an activated sludge microbiome
This study investigated the effects of adding biochar (BC) on the fate of ciprofloxacin (CIP) and its related antibiotic tolerance (AT) in activated sludge. Three activated sludge reactors were established with different types of BC, derived from apple, pear, and mulberry tree, respectively, and one reactor with no BC. All reactors were exposed to an environmentally relevant level of CIP that acted as a definitive selective pressure significantly promoting AT to four representative antibiotics (CIP, ampicillin, tetracycline, and polymyxin B) by up to two orders of magnitude. While CIP removal was negligible in the reactor ...
Source: Environmental Pollution - May 8, 2022 Category: Environmental Health Authors: Seungdae Oh Youngjun Kim Donggeon Choi Ji Won Park Jin Hyung Noh Sang-Yeop Chung Sung Kyu Maeng Chang-Jun Cha Source Type: research

Chalcone Derivatives as Potential Inhibitors of P-Glycoprotein and NorA: An < em > In Silico < /em > and < em > In Vitro < /em > Study
Biomed Res Int. 2022 Mar 26;2022:9982453. doi: 10.1155/2022/9982453. eCollection 2022.ABSTRACTThe human P-glycoprotein (P-gp) and the NorA transporter are the major culprits of multidrug resistance observed in various bacterial strains and cancer cell lines, by extruding drug molecules out of the targeted cells, leading to treatment failures in clinical settings. Inhibiting the activity of these efflux pumps has been a well-known strategy of drug design studies in this regard. In this manuscript, our earlier published machine learning models and homology structures of P-gp and NorA were utilized to screen a chemolibrary of...
Source: Biomed Res - April 5, 2022 Category: Research Authors: Minh-Tri Le Dieu-Thuong Thi Trinh Trieu-Du Ngo Viet-Khoa Tran-Nguyen Dac-Nhan Nguyen Tung Hoang Hoang-Minh Nguyen Tran-Giang-Son Do Tan Thanh Mai Thanh-Dao Tran Khac-Minh Thai Source Type: research

Celiac Disease: A Serious, Life-Changing Condition
I met Paul Graham courtesy of one of his essays.  Then, we talked by phone and I read – no devoured – his book, In Memory of Bread: A Memoir. Pardon the pun. Paul is a professor of English Department at St. Lawrence University in Canton, NY and on July 1 becomes Department Chair. He focuses on fiction and non-fiction creative writing and lives with his wife, Bec and their German shepherds. Paul, your book is the best description I’ve read about the challenges of being diagnosed with celiac. Can you summarize what happened? Given your experience, what recommendations would you have for clinicians? Should celiac be su...
Source: Disruptive Women in Health Care - June 5, 2017 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs

Bayesian models for screening and TB Mobile for target inference with Mycobacterium tuberculosis
Summary: The search for compounds active against Mycobacterium tuberculosis is reliant upon high-throughput screening (HTS) in whole cells. We have used Bayesian machine learning models which can predict anti-tubercular activity to filter an internal library of over 150,000 compounds prior to in vitro testing. We used this to select and test 48 compounds in vitro; 11 were active with MIC values ranging from 0.4 μM to 10.2 μM, giving a high hit rate of 22.9%. Among the hits, we identified several compounds belonging to the same series including five quinolones (including ciprofloxacin), three molecules with long aliph...
Source: Tuberculosis - January 21, 2014 Category: Respiratory Medicine Authors: Sean Ekins, Allen C. Casey, David Roberts, Tanya Parish, Barry A. Bunin Tags: Drug Discovery and Resistance Source Type: research