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More Painkillers May Raise Heart Risks for Older Women: Review
Class of drugs that includes naproxen linked to increased chance of heart attack, stroke, but finding not conclusive
Source: WebMD Health - July 8, 2014 Category: Consumer Health News Source Type: news
More Painkillers May Raise Heart Risks for Older Women
Class of drugs that includes naproxen linked to increased chance of heart attack, stroke, but finding not conclusive
Source: HealthDay
Related MedlinePlus Pages: Heart Attack, Heart Disease in Women, Pain Relievers
Source: MedlinePlus Health News - July 8, 2014 Category: Consumer Health News Source Type: news
Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Outcomes in Women: Results From the Women's Health Initiative Original Articles
Conclusions—
Regular use of selective cox-2 inhibitors and nonselective NSAIDs with cox-2>cox-1 inhibition showed a modestly increased hazard for cardiovascular events. Nonselective agents with cox-1>cox-2 inhibition were not associated with increased cardiovascular risk.
Clinical Trial Registration—
URL: www.clinicaltrials.gov. Unique identifier: NCT00000611.
Source: Circulation: Cardiovascular Quality and Outcomes - July 15, 2014 Category: Cardiology Authors: Bavry, A. A., Thomas, F., Allison, M., Johnson, K. C., Howard, B. V., Hlatky, M., Manson, J. E., Limacher, M. C. Tags: Risk Factors Original Articles Source Type: research
Cardiovascular Pharmacogenetics of Anti-Thrombotic Agents and Non-Steroidal Anti-Inflammatory Drugs.
Abstract
The use of antithrombotic agents, particularly antiplatelet drugs like aspirin and clopidogrel, has been instrumental in decreasing the risk for adverse cardiovascular events across a wide range of patients. However, despite the established benefits, the use of these medications remains suboptimal. There is a high degree of inter-individual variation in response to these treatments, whereby patients experience occlusive thromboembolic events, in spite of maintaining an appropriate treatment regimen. This has lead to the notion of antithrombotic "resistance" or "poor responders", which has been a growing c...
Source: Current Molecular Medicine - August 11, 2014 Category: Molecular Biology Authors: Stitham J, Vanichakarn P, Ying L, Hwa J Tags: Curr Mol Med Source Type: research
How to tame stubbornly high blood pressure
High blood pressure is a leading cause of stroke
and heart disease. Dozens of medications and other therapies are available to
treat high blood pressure, also known as hypertension. Yet many people can't
get their blood pressure under control even by taking multiple medications, reports
the September 2014 Harvard Heart Letter.
"When people have high blood pressure despite being on
three different medications, including a thiazide diuretic, they have what's
known as resistant hypertension," says Dr. Joshua Beckman, a cardiologist
at Harvard-affiliated Brigham and Women's Hospital.
Some people with resistant hypertension may...
Source: New Harvard Health Information - August 23, 2014 Category: Consumer Health News Source Type: news
Alexia with agraphia as a rare presentation of migraine (P1.309)
CONCLUSIONS:This represents the first-ever case report of alexia with agraphia presenting as migraine aura. The pathophysiology of cortical spreading depression within migraine auras easily supports cortical dysfunction of the angular gyrus preceding or during a migraine attack.Disclosure: Dr. Suhaib has nothing to disclose. Dr. Vaughn has received personal compensation for activities with various multiple sclerosis surveys.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Suhaib, O., Vaughn, A. Tags: Headache I Source Type: research
FDA Strengthens Warnings on Class of Painkillers
The FDA strengthened its safety warnings about heart-attack and stroke risks linked to a class of common pain relievers that includes medicines such as Celebrex, Advil, Motrin IB and Aleve.
Source: WSJ.com: Health - July 10, 2015 Category: Pharmaceuticals Tags: PAID Source Type: news
Experts Urge Caution with Popular Painkillers After FDA Warning
Tougher labels reflect mounting evidence that NSAIDs such as ibuprofen, naproxen raise heart, stroke risk
Source: HealthDay
Related MedlinePlus Pages: Drug Safety, Pain Relievers
Source: MedlinePlus Health News - July 10, 2015 Category: Consumer Health News Source Type: news
Experts Urge Sparing Use of Nonaspirin Painkillers
The Food and Drug Administration said it would ask drug manufacturers to change the labels to reflect evidence that nonaspirin, nonsteroidal anti-inflammatory drugs increased the risk of heart attacks and strokes.
Source: NYT Health - July 14, 2015 Category: Consumer Health News Authors: SABRINA TAVERNISE Tags: Pain-Relieving Drugs Heart Aleve (Drug) Celebrex (Drug) Drugs (Pharmaceuticals) Motrin IB Food and Drug Administration Labeling and Labels (Product) Stroke Ibuprofen (Drug) Source Type: news
Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep.
What exactly is gout?
Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine.
However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news
Rat paw oedema modeling and NSAIDs: Timing of effects.
CONCLUSIONS: Single-dose administration of naproxen (15 mg/kg) or indomethacin (10 mg/kg) exerts decrease in rat paw oedema volume at no later than 5 hours after oedema induction by carrageenan. Evaluating anti-inflammatory activity by the areas under the curve «increase in paw volume - time» proves that a single-dose NSAID's administration has no effect on the inflammatory response when evaluated not by single time-point index (at 3 or 5 hours), but by assessing the oedema development and duration over 192 hours (8 days).
PMID: 26639722 [PubMed - in process]
Source: International Journal of Risk and Safety in Medicine - December 9, 2015 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
Top 20 Research Studies of 2015 for Primary Care Physicians.
This article, the fifth installment in this annual series, summarizes the 20 POEMs based on original research studies judged to have the greatest clinical relevance for family physicians. Key recommendations include questioning the need for backup throat cultures; avoiding early imaging and not adding cyclobenzaprine or oxycodone to naproxen for patients with acute low back pain; and encouraging patients with chronic or recurrent low back pain to walk. Other studies showed that using a nicotine patch for more than eight weeks has little benefit; that exercise can prevent falls that cause injury in at-risk older women; and ...
Source: American Family Physician - April 30, 2016 Category: Primary Care Authors: Ebell MH, Grad R Tags: Am Fam Physician Source Type: research
Turmeric: Nature ’s Miracle Root for Disease
My friends Lelir and Westi in Bali don’t like to go to doctors. Nature is their pharmacy.
You see, Lelir is a Balian. That means “herbal healer.”
And Westi’s plantation is bursting with healing plants.
But one plant stands out above all the others. Lelir uses it to make a daily immune-boosting elixir as well as an anti-aging facial scrub. Balians use it as an antibiotic and for liver support. They boil it with milk and sugar to treat the common cold and allergies. Rural doctors make it into a paste with lime to ease sore joints. They make drinks to treat fevers and stomach pain. They mix it wi...
Source: Al Sears, MD Natural Remedies - September 20, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news
Celebrex Is No Riskier For Heart Than Other Arthritis Drugs, Study Finds
NEW ORLEANS (AP) — A new study gives some reassurance to arthritis sufferers who want pain relief but are worried about side effects. It finds that Celebrex, a drug similar to ones withdrawn 12 years ago for safety reasons, is no riskier for the heart than some other prescription pain pills that are much tougher on the stomach.
“We do not want patients to suffer with pain and we need to know what is safe to give them,” said Dr. Steven Nissen, the Cleveland Clinic’s heart chief, who led the study. Fear that Celebrex would be worse than alternatives proved unfounded, and “on almost every endpoint it...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 14, 2016 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Arthritis Celebrex Source Type: news
Coxibs Refocus Attention on the Cardiovascular Risks of Non-Aspirin NSAIDs
This article explains how coxibs refocused attention on the cardiovascular safety of NSAIDs and the general implications of that. COX-2 activity/specificity is one factor associated with increased cardiovascular risks; however, these risks cannot be attributed to coxibs alone. The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity. All NSAIDs, whether traditional or a coxib, pose some cardiovascular risks. It is possible that clinicians continue to focus more on decreasing the immediate gastric risks than preventing the later c...
Source: American Journal of Cardiovascular Drugs - March 28, 2017 Category: Cardiology Source Type: research
